Through the Zoom window: How children use virtual technologies to navigate power dynamics in research.

Virtual technologies gained popularity during the COVID-19 pandemic for use in research, including research with children. As scholarship from the field of science, technology and society (STS) suggests, technologies are never neutral, but embedded with social values and, as such, used by people to navigate identities and relationships. Building on childhood studies research that has shown how children appropriate and use research tools, this article asks: How do child research participants use this virtual "window" into their homes and their lives? Using observations from a virtual and in-person study in the United States, we show how children used virtual technologies to manage relationships, filter what researchers saw of their lives, and navigate issues of privacy and self-disclosure.

Phishing vulnerability compounded by older age, apolipoprotein E e4 genotype, and lower cognition.

With technological advancements, financial exploitation tactics have expanded into the online realm. Older adults may be particularly susceptible to online scams due to age- and Alzheimer's disease-related changes in cognition. In this study, 182 adults ranging from 18 to 90 years underwent cognitive assessment, genotyping for apolipoprotein E e4 (APOE4), and completed the lab-based Short Phishing Email Suspicion Test (S-PEST) as well as the real-life PHishing Internet Task (PHIT).

Auditory aversive generalization learning prompts threat-specific changes in alpha-band activity.

Pairing a neutral stimulus with aversive outcomes prompts neurophysiological and autonomic changes in response to the conditioned stimulus (CS+), compared to cues that signal safety (CS-). One of these changes-selective amplitude reduction of parietal alpha-band oscillations-has been reliably linked to processing of visual CS+. It is, however, unclear to what extent auditory conditioned cues prompt similar changes, how these changes evolve as learning progresses, and how alpha reduction in the auditory domain generalizes to similar stimuli.

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking.

Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we assessed whether co-consumption of oxycodone and alcohol influence the intake of one another, demand for oxycodone, and the neurocircuitry underlying cue-primed reinstatement of oxycodone-seeking. Male and female rats underwent oxycodone intravenous self-administration (IVSA) with homecage access to alcohol (20% v/v) and/or water immediately after the IVSA session.

Selective effects of conspecific movement on social preference in zebrafish (Danio rerio) using real-time 3D tracking and 3D animation.

Zebrafish show social behavior such as shoaling and schooling, which is a result of complex and interdependent interactions among conspecifics. Zebrafish social behavior is interdependent in the sense that one fish's behavior affects both conspecific behavior and, as a result, their own behavior. Previous research examined effects of the interdependent interactions on the preference for social stimulus but lacked clear evidence that specific conspecific movements were reinforcing.

Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse.

Rationale: There are no FDA-approved treatments to facilitate recovery from cocaine use disorder. Contingency management offers non-drug reinforcers to encourage abstinence and is effective at reducing drug seeking during treatment, but once discontinued, relapse rates increase.

Objectives: We sought to establish a choice-based rodent model of voluntary abstinence (VA) from cocaine to test the ability of ceftriaxone, an antibiotic consistently shown to prevent relapse to cocaine seeking in rodents, to attenuate relapse after discontinuation of VA, and to investigate relapse-induced neuronal activation via c-Fos expression.

The roles of rat medial prefrontal and orbitofrontal cortices in relapse to cocaine-seeking: A comparison across methods for identifying neurocircuits.

A large body of research supports the notion that regions of the rodent frontal cortex regulate reinstatement of cocaine seeking after cessation of intravenous cocaine self-administration. However, earlier studies identifying the roles of medial (mPFC) and orbital prefrontal cortices (OFC) in reinstatement relied on pharmacological inactivation methods, which indiscriminately inhibited cells within a target region. Here, we first review the anatomical borders and pathways of the rat mPFC and OFC.

Stress resilience-associated behaviors following predator scent stress are accompanied by upregulated nucleus accumbens mGlu5 transcription in female Sprague Dawley rats.

Despite the higher prevalence of post-traumatic stress disorder (PTSD) in women, the majority of preclinical research has been conducted utilizing male subjects. We have found that male rats exposed to the predator scent 2,4,5-trimethyl-3-thiazoline (TMT) show heterogenous long-term anxiety-like behavior and conditioned fear to the TMT environment. Stress-Resilient males exhibit increased mGlu5 mRNA expression in the basolateral amygdala (BLA) and prefrontal cortex (PFC).

Mesenchymal Stromal Cells in Ischemic Brain Injury.

Ischemic brain injury represents a major cause of death worldwide with limited treatment options with a narrow therapeutic window. Accordingly, novel treatments that extend the treatment from the early neuroprotective stage to the late regenerative phase may accommodate a much larger number of stroke patients. To this end, stem cell-based regenerative therapies may address this unmet clinical need.

The role of analytical reasoning and source credibility on the evaluation of real and fake full-length news articles.

Aim: Previous research has focused on accuracy associated with real and fake news presented in the form of news headlines only, which does not capture the rich context news is frequently encountered in real life. Additionally, while previous studies on evaluation of real and fake news have mostly focused on characteristics of the evaluator (i.e.

Reducing Response Effort to Improve Employee Preparedness in a Human Service Organization.

We examined the effectiveness of reducing response effort and an e-mail prompt for increasing preparedness of 17 therapists for a social skills group in a human services organization. We evaluated whether participants knew the correct lession and sport and whether they felt prepared for the session via a paper survey. The Performance Diagnostic Checklist-Human Services indicated deficiencies in all four domains.

Hippocampal volume and navigational ability: The map(ping) is not to scale.

A critical question regards the neural basis of complex cognitive skill acquisition. One extensively studied skill is navigation, with evidence suggesting that humans vary widely in navigation abilities. Yet, data supporting the neural underpinning of these individual differences are mixed.

Sexual Arousal Discounting: Devaluing Condom-Protected Sex as a Function of Reduced Arousal.

Sexual discounting is a growing area of research aimed at identifying factors that reduce people's reported willingness to have safe sex. One commonly reported reason for condom non-use is that a condom reduces sexual arousal. However, researchers have yet to isolate the specific role of sexual arousal using a sexual discounting framework.

Defending subjective inflation: an inference to the best explanation.

In a recent opinion piece, Abid (2019) criticizes the hypothesis that subjective inflation may partly account for apparent phenomenological richness across the visual field and outside the focus of attention. In response, we address three main issues. First, we maintain that inflation should be interpreted as an intraperceptual-and not post-perceptual-phenomenon.

Spatial direction comprehension in images, arrows, and words in two patients with posterior cortical atrophy.

To successfully move through the world, the brain constructs spatial representations that situate the body within the environment. Communicating spatial directions poses specific challenges to this process, in part because the format through which the information is communicated must be interpreted to match the visual scene the navigator is viewing while traversing that space. For example, if a navigator needs to turn left to reach a goal, the information may be presented in the form of words ("turn left"), schemas (arrows pointing left), or images of the specific left turn.

Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.

Background: The neuropeptide oxytocin (OT) has been shown to play a role in variety of cognitive and social processes and different hypotheses have been put forth to explain OT's effects on brain and behavior in humans. However, these previous explanatory accounts do not provide information about OT-related temporal modulation in the brain.

Objectives: This paper systematically reviewed intranasal OT administration studies employing event-related potentials (ERPs) and synthesized the existing evidence into a novel conceptual framework.

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease.

Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent models of neurological diseases and substance use disorders. However, the mechanism behind GLT-1 upregulation is unknown.

Ceftriaxone and mGlu2/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats.

Rationale: The beta-lactam antibiotic ceftriaxone reliably attenuates the reinstatement of cocaine seeking. While the restoration of nucleus accumbens core (NA core) GLT-1 expression is necessary for ceftriaxone to attenuate reinstatement, AAV-mediated GLT-1 overexpression is not sufficient to attenuate reinstatement and does not prevent glutamate efflux during reinstatement.

Aims: Here, we test the hypothesis that ceftriaxone attenuates reinstatement through interactions with glutamate autoreceptors mGlu2 and mGlu3 in the NA core.

Now you feel it, now you don't: Motivated attention to emotional content is modulated by age and task demands.

Several studies with younger adults have examined the degree to which emotion captures attention using the event-related potentials (ERP) technique, but it is unknown whether there are age-related differences on this issue. We examined ERP correlates of age-related differences in processing of task-relevant and task-irrelevant emotional material. Participants viewed emotional or neutral images, presented at fixation, flanked by two bars of either differing or matching orientation.

Impairments in reversal learning following short access to cocaine self-administration.

Background: Cocaine use disorder is characterized by compulsive drug-seeking that persists long into abstinence. Work using rodent models of cocaine addiction has found evidence for reversal learning deficits 21 days after non-contingent cocaine administration and 60 days after self-administration. Here we sought to determine if a deficit in reversal learning is present 3-4 weeks after cessation of cocaine self-administration, when relapse to cocaine-seeking is robust.

The importance of considering polysubstance use: lessons from cocaine research.

Background: Polysubstance use (PSU) is prevalent among individuals with substance use disorders, but the vast majority of preclinical substance use research has focused on individual substances in isolation. Cocaine has been prevalent in the repertoire of persons who use more than one illicit substance.

Methods: We conducted a meta-analysis combining results from literature searches and secondary data analyses to estimate the prevalence of simultaneous and concurrent cocaine + alcohol and cocaine + cannabis use among cocaine users.

Inducing more sleep on school nights reduces sedentary behavior without affecting physical activity in short-sleeping adolescents.

Objectives/background: Short sleep duration during adolescence is associated with increased dietary intake and greater risk for overweight/obesity. However, findings are mixed on the relationship between sleep and physical activity (PA) during the school year, when short sleep duration is most common. Furthermore, there is concern that increasing sleep duration may interfere with opportunities for PA, yet this has not been directly tested.

The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens.

Rationale: Effective pharmacological treatments to prevent cocaine relapse remain elusive. In male rats, ceftriaxone attenuates the reinstatement of cocaine-seeking while increasing glutamate transporter-1 (GLT-1) and xCT expression in the nucleus accumbens core (NAc). Despite reported sex differences in cocaine relapse, these effects have not yet been confirmed in female rats.