2 results match your criteria: "941 Hospital of Joint Logistics Support Force of PLA[Affiliation]"

M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors.

J Transl Med

March 2023

State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Air Force Medical University, Xi'an, Shaanxi, China.

Background: Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M therapy has shown unique and impressive antitumor effects in immunotherapy for solid tumors. However, the polarization state of macrophages can affect the antitumor effect of CAR-M.

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Article Synopsis
  • Cervical cancer is the 4th most common cancer in women globally, often linked to high-risk HPV infections.
  • A study in Xi'an, China, screened 14,655 women aged 30-65 and found an overall HPV infection prevalence of 13.5%.
  • High-risk HPV types like HPV-52 and HPV-16 were the most common, with specific prevalence varying by region and age, notably peaking in women over 60.
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