7 results match your criteria: "930N University AVE[Affiliation]"
Angew Chem Int Ed Engl
September 2024
Organic and Inorganic Chemistry Department, University of Oviedo, Avenida Julián Clavería 8, 33006, Oviedo, Spain.
The direct synthesis of alkenes from alkynes usually requires the use of transition-metal catalysts. Unfortunately, efficient biocatalytic alternatives for this transformation have yet to be discovered. Herein, the selective bioreduction of electron-deficient alkynes to alkenes catalysed by ene-reductases (EREDs) is described.
View Article and Find Full Text PDFJ Mater Chem A Mater
November 2023
Department of Chemistry, University of Michigan, 930N University Ave, Ann Arbor, MI 48109, USA.
Nonaqueous redox flow batteries (NARFBs) offer a promising solution for large-scale storage of renewable energy. However, crossover of redox active molecules between the two sides of the cell is a major factor limiting their development, as most selective separators are designed for deployment in water, rather than organic solvents. This report describes a systematic investigation of the crossover rates of redox active organic molecules through an anion exchange separator under RFB-relevant non-aqueous conditions (in acetonitrile/KPF) using a combination of experimental and computational methods.
View Article and Find Full Text PDFChemistry
February 2023
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, København, Denmark.
The nanoviscosity experienced by molecules in solution may be determined through measurement of the molecular rotational correlation time, τ , for example, by fluorescence and NMR spectroscopy. With this work, we apply PAC spectroscopy to determine the rate of rotational diffusion, λ=1/τ , of a de novo designed protein, TRIL12AL16C, in solutions with viscosities, ξ, from 1.7 to 88 mPa⋅s.
View Article and Find Full Text PDFChembiochem
September 2020
Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 28104, USA.
The fungal indole alkaloids are a unique class of complex molecules that have a characteristic bicyclo[2.2.2]diazaoctane ring and frequently contain a spiro-oxindole moiety.
View Article and Find Full Text PDFChemistry
April 2020
Chemistry Department, University of Michigan, 930N. University Ave., Ann Arbor, MI, 48109, USA.
This article presents a new strategy for achieving regiocontrol over the endo versus exo modes of cycloisomerizations of epoxide-containing alcohols, which leads to the formation of five- or six-membered cyclic ethers. Unlike traditional methods relying on achiral reagents or enzymes, this approach utilizes chiral phosphoric acids to catalyze the regiodivergent selective formations of either tetrahydrofuran- or tetrahydropyran-containing products. By using methyl ester of epoxide-containing antibiotic mupirocin as the substrate, it is demonstrated that catalytic chiral phosphoric acids (R)-TCYP and (S)-TIPSY could be used to achieve the selective formation of either the six-membered endo product (95:5 r.
View Article and Find Full Text PDFJ Neurosci Methods
March 2015
University of Michigan, Department of Chemistry, 930N University Ave, Ann Arbor, MI, 48109, United States. Electronic address:
Background: Neurochemical monitoring via sampling probes is valuable for deciphering neurotransmission in vivo. Microdialysis is commonly used; however, the spatial resolution is poor.
New Method: Recently push-pull perfusion at low flow rates (50nL/min) has been proposed as a method for in vivo sampling from the central nervous system.
Biosens Bioelectron
January 2006
Department of Chemistry, The University of Michigan, 930N University AVE, Ann Arbor, MI 48109, USA.
The wild type form of Red fluorescent protein (DsRed), an intrinsically fluorescent protein found in tropical corals, is found to be highly selective, reversible and sensitive for both Cu(+) and Cu(2+), with a nanomolar detection limit. The selectivity towards these ions is retained even in the presence of other heavy metal ions. The K(d) values for monovalent and divalent copper, based on single binding isotherms, are 450 and 540 nM, respectively.
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