9 results match your criteria: "920th Hospital of the PLA Joint Logistics Support Force[Affiliation]"
Infectious hepatitis E virus excreted into the vagina.
FASEB J
March 2024
School of Medicine, The Academy for Cells and Life Health, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, PR China.
Article Synopsis
- Hepatitis E virus (HEV) has been found in the female genital tract, which had not been previously reported, indicating a potential link to reproductive health issues.
- Vaginal secretions, cervical smears, and cervix uteri samples showed the presence of HEV RNA and antigens, suggesting the virus can be transmitted in women.
- In experimental models, HEV caused significant damage to the genital tract and heightened inflammatory responses, showing the virus’s impact on female reproductive health.
The primary site of infection in COVID-19 exhibit is the respiratory system, but multiple organ systems could be affected. The virus could directly invade cardiomyocytes. Alternatively, cytokine storm could lead to myocardial injury.
View Article and Find Full Text PDFMechanism of Thymus Rejuvenation in Elderly Macaques.
Rejuvenation Res
October 2022
The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Article Synopsis
- Senile thymus atrophy contributes to reduced immune function, making it important to repair thymus tissue and restore immune activity in the elderly.
- In a study, elderly macaques were treated with bone marrow mesenchymal stem cells, resulting in increased thymus volume, reduced fibrosis, and signs of tissue regeneration.
- Transcriptomic analysis revealed that after stem cell therapy, the thymus expression patterns in old macaques resembled those of younger ones, suggesting this therapy could prevent or reverse thymus aging.
SOCS2 is a potential prognostic marker that suppresses the viability of hepatocellular carcinoma cells.
Oncol Lett
May 2021
Department of Gastroenterology, 920th Hospital of The PLA Joint Logistics Support Force, Kunming, Yunnan 650032, P.R. China.
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated mortality worldwide. Thus, there is an urgent requirement to identify novel diagnostic and prognostic biomarkers for this disease. The present study aimed to identify the hub genes associated with the progression and prognosis of patients with HCC.
View Article and Find Full Text PDFThe effects of BMMSC treatment on lung tissue degeneration in elderly macaques.
Stem Cell Res Ther
March 2021
Kunming Key Laboratory of Stem Cell and Regenerative Medicine, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, 650032, Yunnan Province, China.
Article Synopsis
- Age-related degeneration of lung tissue increases the risk of severe lung diseases, making the search for anti-aging treatments crucial.
- A study on elderly macaque models found that administration of bone marrow-derived mesenchymal stem cells (BMMSCs) significantly improved lung health by reducing fibrosis and inflammation.
- BMMSC treatment was effective in decreasing harmful oxidative stress and enhancing the function and proliferation of lung cells, suggesting it could be a viable method to combat age-related lung degeneration.
Effect and mechanism of human umbilical cord mesenchymal stem cells in treating allergic rhinitis in mice.
Sci Rep
November 2020
Kunming Key Laboratory of Stem Cell and Regenerative Medicine, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, 650032, Yunnan, China.
Article Synopsis
- A mouse model for allergic rhinitis (AR) was developed using BALB/c mice to aid in future research on the condition.
- * The study involved preparing human umbilical cord mesenchymal stem cells (hUCMSCs), which were shown to be effective for tracking in animal studies and possibly for AR treatment.
- * The transplantation of hUCMSCs, particularly through tail vein injection, demonstrated positive effects on the AR model, with a significant presence of these cells in the nasal area after two weeks.
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.
Aging (Albany NY)
September 2020
Kunming Key Laboratory of Stem Cell and Regenerative Medicine, 920th Hospital of The PLA Joint Logistics Support Force, Kunming, Yunnan Province, China.
Article Synopsis
- The study aimed to investigate how allogeneic umbilical cord mesenchymal stem cell (mUCMSC) transplantation affects the thymus in aging mice, potentially offering a new treatment for age-related thymic atrophy.
- Results indicated that mUCMSC treatment improved thymus structure and function by analyzing changes in thymic tissue and immune cell markers, as well as promoting hair regeneration in the mice.
- The findings suggest that mUCMSCs can reduce thymus aging by affecting specific senescence-related genes, though further research is needed to fully understand the underlying mechanisms.
Upregulation of Orai1 and increased calcium entry contribute to angiotensin II-induced human coronary smooth muscle cell proliferation: Running Title: Angiotensin II-induced human coronary smooth muscle cells proliferation.
Peptides
November 2020
Department of Cardiology, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, Yunnan, 650032, China. Electronic address:
Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism remains unclear. Orai1 and Stim1 are the main components of store-operated Ca entry (SOCE), which has an important effect on VSMC proliferation. In the present study, we showed that Ang II-induced human coronary smooth muscle cell (HCSMC) proliferation was associated with increased calcium entry.
View Article and Find Full Text PDFMechanism and therapeutic effect of umbilical cord mesenchymal stem cells in inflammatory bowel disease.
Sci Rep
November 2019
Kunming Key Laboratory of Stem Cell and Regenerative Medicine, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, Yunnan Province, 650032, China.
Article Synopsis
- Inflammatory bowel disease (IBD) causes chronic inflammation in the gastrointestinal tract, and researchers are exploring new treatments with minimal side effects.
- Mouse models of IBD were created using a solution called DSS, allowing scientists to test the effects of umbilical cord mesenchymal stem cells (UCMSCs) from both mice and humans.
- The study found that UCMSCs improve survival rates and promote healing by enhancing key proteins in the intestines, offering a promising avenue for future IBD therapies.