2 results match your criteria: "905th Hospital of People's Liberation Army of China (PLA) Navy[Affiliation]"
Succinylation modification provides new insights for the treatment of immunocompromised individuals with drug-resistant infection.
Front Immunol
May 2023
Department of Pharmacy, 905th Hospital of People's Liberation Army of China (PLA) Navy, Shanghai, China.
Article Synopsis
- Invasive infections are a major health threat, particularly to those with weakened immune systems, and triazole drugs like itraconazole (ITR) face challenges due to drug-resistant strains, leading to high mortality rates.
- A study reveals significant differences in lysine succinylation among fungal strains with varying ITR resistance, highlighting its impact on cell metabolism and the potential role in antifungal resistance.
- The deducing of using the dessuccinylase inhibitor nicotinamide (NAM) showed promising results in improving survival rates in infected mice and enhancing macrophage activity against infections, presenting new treatment avenues for combating ITR-resistant fungal infections.
Species within the spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on the rise, and the emergence of triazole-resistant spp.
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