397 results match your criteria: "90014 University of Oulu[Affiliation]"
Annu Int Conf IEEE Eng Med Biol Soc
May 2009
Department of Electrical and Information Engineering, BOX 4500, FIN-90014 University of Oulu, Finland.
This paper studies how remifentanil, a commonly used intraoperative opioid, affects the relation of the onset of burst suppression pattern (BSP) and the spectral changes of EEG during anesthesia. The onsets of BSP were detected using both manual and the automatic method proposed from the EEGs of twenty-seven patients who had received different amount of remifentanil with the anesthetic. The spectral changes were determined by calculating the frequency progression patterns of the EEGs.
View Article and Find Full Text PDFJ Exp Bot
May 2009
Department of Biology, PO Box 3000, 90014 University of Oulu, Finland.
To date, haemoglobins (Hbs) have been shown to exist in all kingdoms of life. The least studied and understood groups are plant non-symbiotic haemoglobins (nsHbs) and the recently found plant truncated Hbs (trHbs). From a biotechnological point of view, the best characterized and almost exclusively applied Hb is the bacterial Vitreoscilla haemoglobin (VHb).
View Article and Find Full Text PDFJ Phys Chem B
January 2009
Department of Physical Sciences, P.O.Box 3000, 90014 University of Oulu, Finland.
The walls of solid matrix restrict the self-diffusion of a fluid absorbed in the matrix, and this is reflected in the echo amplitudes measured by PGSTE NMR. Hence, the pore size distribution of the matrix can be extracted from the echo amplitudes. We demonstrate that, when both liquids and gases (water and methane in this case) are used as probe fluids, the scale of the dimensions observable by PGSTE NMR may be over 4 orders of magnitude.
View Article and Find Full Text PDFRespir Res
December 2008
Institute of Clinical Medicine, Department of Internal Medicine, Centre of Excellence in Research, P O Box 5000, 90014 University of Oulu, Oulu, Finland.
Background: Oxidative stress plays a potential role in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Glutathione S-transferases (GSTs) detoxify toxic compounds in tobacco smoke via glutathione-dependent mechanisms. Little is known about the regulation and expression of GSTs in COPD lung and their presence in airway secretions.
View Article and Find Full Text PDFBiol Rev Camb Philos Soc
February 2009
Finnish Environment Institute, Department of Biology, FI-90014 University of Oulu, Finland.
Current rates of climate change are unprecedented, and biological responses to these changes have also been rapid at the levels of ecosystems, communities, and species. Most research on climate change effects on biodiversity has concentrated on the terrestrial realm, and considerable changes in terrestrial biodiversity and species' distributions have already been detected in response to climate change. The studies that have considered organisms in the freshwater realm have also shown that freshwater biodiversity is highly vulnerable to climate change, with extinction rates and extirpations of freshwater species matching or exceeding those suggested for better-known terrestrial taxa.
View Article and Find Full Text PDFExp Cell Res
January 2009
Institute of Biomedicine, Department of Anatomy and Cell Biology, P.O. Box 5000 (Aapistie 7), FIN-90014 University of Oulu, Finland.
We investigated the targeting of the gamma-actin isoform in skeletal myofibers. For this purpose we used expression vectors to produce green fluorescent protein (GFP-) as well as myc-tagged gamma-actin in rat flexor digitorum brevis myofibers. We found that the gamma-actin fusion proteins accumulated into Z discs but not beneath the sarcolemma.
View Article and Find Full Text PDFArch Oral Biol
January 2009
Institute of Dentistry, 90014 University of Oulu, Oulu, Finland.
Am J Hum Genet
October 2008
Department of Biochemistry, University of Oulu, PO Box 3000, FI-90014 University of Oulu, Finland.
Lysyl hydroxylase 3 (LH3, encoded by PLOD3) is a multifunctional enzyme capable of catalyzing hydroxylation of lysyl residues and O-glycosylation of hydroxylysyl residues producing either monosaccharide (Gal) or disaccharide (Glc-Gal) derivatives, reactions that form part of the many posttranslational modifications required during collagen biosynthesis. Animal studies have confirmed the importance of LH3, particularly in biosynthesis of the highly glycosylated type IV and VI collagens, but to date, the functional significance in vivo of this enzyme in man is predominantly unknown. We report here a human disorder of LH3 presenting as a compound heterozygote with recessive inheritance.
View Article and Find Full Text PDFCirculation
October 2008
Institute of Biomedicine, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland.
Background: Extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38-MAPK) have been shown to regulate various cellular processes, including cell growth, proliferation, and apoptosis in the heart. However, the function of these signaling pathways in the control of cardiac contractility is unclear. Here, we characterized the contribution of ERK1/2 and p38-MAPK to the inotropic effect of endothelin-1 (ET-1).
View Article and Find Full Text PDFCochlear Implants Int
June 2005
Department of Finnish, Information Studies and Logopedics, PO Box 1000, FIN-90014 University of Oulu, Finland.
Objective: This study aimed at investigating the association between speech perception and categories of auditory performance (mCAP) in everyday life for adult cochlear implant users.
Design: A prospective repeated measures design over a two-year follow-up period was used.
Methods: The speech perception and auditory performance of 19 Finnish-speaking adults were assessed before implantation and 1, 3, 6, 12 and 24 months after switching on the implant.
Exp Cell Res
August 2008
Oulu Centre for Cell-Matrix Research, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, P.O.B. 5000, 90014 University of Oulu, Finland.
The Wnt family of glycoprotein growth factors controls a number of central cellular processes such as proliferation, differentiation and ageing. All the Wnt proteins analyzed so far either activate or inhibit the canonical beta-catenin signaling pathway that regulates transcription of the target genes. In addition, some of them activate noncanonical signaling pathways that involve components such as the JNK, heterotrimeric G proteins, protein kinase C, and calmodulin-dependent protein kinase II, although the precise signaling mechanisms are only just beginning to be revealed.
View Article and Find Full Text PDFJ Exp Bot
August 2008
Department of Biology, PO Box 3000, 90014 University of Oulu, Finland.
Present knowledge on plant non-symbiotic class-1 (Hb1) and truncated (TrHb) haemoglobin genes is almost entirely based on herbaceous species while the corresponding tree haemoglobin genes are not well known. The function of these genes has recently been linked with endosymbioses between plants and microbes. In this work, the coding sequences of hybrid aspen (Populus tremulaxtremuloides) PttHb1 and PttTrHb were characterized, indicating that the key residues of haem and ligand binding of both genes were conserved in the deduced amino acid sequences.
View Article and Find Full Text PDFBr J Psychiatry
June 2008
Department of Psychiatry, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland.
Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.
View Article and Find Full Text PDFJ Biomed Opt
August 2008
University of Oulu, Optoelectronics and Measurement Techniques Laboratory and Infotech Oulu, P.O. Box 4500, FIN-90014 University of Oulu, Finland.
Intralipid is a well-known emulsion used as a tissue-simulating phantom in developing optical imaging and diagnostic techniques for medical applications. The optical coherence tomography (OCT), pulsed photoacoustic (PA), and time-of-flight (TOF) techniques were used to detect glucose-induced changes in the optical properties of Intralipid. A comparison of the applicability of these techniques to register changes in the scattering properties of Intralipid samples showed that OCT is the most effective method, whereas the sensitivity of the PA technique was less pronounced.
View Article and Find Full Text PDFEur Psychiatry
August 2008
Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014 University of Oulu, Finland.
Purpose: To study the association between age at onset and the clinical picture of schizophrenia in an unselected young birth cohort.
Subjects And Methods: The study sample consists of 98 (64 males and 34 females) individuals with DSM-III-R schizophrenia collected from the Northern Finland 1966 birth cohort. Firstly, subjects were divided into very early- and young-onset subgroups by using the median age at onset (22 years in males and 20 in females), as a cut-off point.
BMC Biotechnol
March 2008
Bioprocess Engineering Laboratory, Dept, of Process and Environmental Engineering, University of Oulu, P.O. Box 4300, FIN-90014 University of Oulu, Finland.
Background: Here we describe a new technical solution for optimization of Pichia pastoris shake flask cultures with the example of production of stable human type II collagen. Production of recombinant proteins in P. pastoris is usually performed by controlling gene expression with the strong AOX1 promoter, which is induced by addition of methanol.
View Article and Find Full Text PDFRheumatology (Oxford)
May 2008
Department of Clinical Chemistry, P.O.Box 5000, FI-90014 University of Oulu, Oulu, Finland.
Objective: To assess the specificity and sensitivity of autoantibodies binding to citrullinated carboxyterminal telopeptides of types I and II collagens in an early arthritis series.
Methods: A cohort of 146 patients from the Kuopio 2000 Arthritis Survey having RA, AS, PsA, ReA, uSpA or undifferentiated arthritis were studied. Autoantibodies binding citrullinated types I and II carboxytelopeptides were measured in two different inhibition ELISA assays.
Lab Anim
January 2008
Laboratory Animal Centre, PO Box 5000, FIN-90014 University of Oulu, Finland.
Veterinary professionals working in partnership with other competent persons are essential for a successful animal care and use programme. A veterinarian's primary responsibilities are defined by their own professional regulatory bodies, but in this area of work there are further opportunities for contribution, which will assist in safeguarding the health and welfare of animals used in research. These guidelines are aimed not only at veterinarians to explain their duties, and outline the opportunities to improve the health and welfare of animals under their care, but also at employers and regulators to help them meet their responsibilities.
View Article and Find Full Text PDFBMC Evol Biol
February 2008
Department of Biology, PO Box 3000, 90014 University of Oulu, Finland.
Background: The role of Wolbachia endosymbionts in shaping the mitochondrial diversity of their arthropod host depends on the effects they have on host reproduction and on the mode of transmission of the bacteria. We have compared the sequence diversity of wsp (Wolbachia surface protein gene) and the host mtDNA in a group of Formica ant species that have diverged approximately 0.5 million years ago (MYA).
View Article and Find Full Text PDFJ Anim Ecol
May 2008
Department of Biology, University of Oulu, PO Box 3000, FI-90014 University of Oulu, Finland.
1. In scramble competition all individuals suffer equally from competition, whereas in contest competition some individuals outperform the others. Generally, larger individuals gain asymmetric advantage in competition over smaller ones.
View Article and Find Full Text PDFActa Crystallogr D Biol Crystallogr
February 2008
Biocenter Oulu and Department of Biochemistry, University of Oulu, PO Box 3000, FIN-90014 University of Oulu, Finland.
The flexible catalytic loop, loop-6, of TIM has evolved to preferably be open in the unliganded state and to preferably be closed in the liganded state. The N-terminal and C-terminal hinges of this loop are important for its opening/closing mechanism. In this study, a small conserved C-terminal hinge residue, Ala178, has been mutated into a residue with a larger side chain, Leu178.
View Article and Find Full Text PDFSchizophr Res
February 2008
Department of Psychiatry, University of Oulu, Finland, P.O. BOX 5000, 90014 University of Oulu, Finland.
Delayed neuromotor development carries an increased risk of developing schizophrenia, and some authors have assumed that risk factors for schizophrenia such as delayed development are also prognostic indicators for patients with established illness. In those who do develop schizophrenia, it is not clear if these same early developmental markers influence the outcome of illness. Our aim was to examine the association between infant developmental milestones and a range of outcomes in patients with schizophrenia.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
November 2008
Department of Chemistry, P.O. Box 3000, FI-90014 University of Oulu, Finland.
The structure of the title compound, (C(24)H(20)P)(2)[Te(2)I(6)], is composed of discrete PPh(4) (+) cations and centrosymmetric [Te(2)I(6)](2-) anions. The tellurium(II) atom shows a sligthly distorted square-planar TeI(4) geometry and is coordinated to two bridging and two terminal iodine atoms. The planar [Te(2)I(6)](2-) ions are isolated by the cations and no inter-molecular tellurium-halogen or halogen-halogen inter-actions are present.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
May 2008
Department of Chemistry, PO Box 3000, FI-90014 University of Oulu, Finland.
The title compound, [HgCl(2)(C(7)H(8)S)](n), was isolated from the reaction of MeSPh with HgCl(2). The Hg(II) atom has a distorted tetra-hedral geometry and is coordinated by one S atom and three Cl atoms. Two of the Cl atoms act as bridging ligands between the Hg atoms, forming a two-dimensional polymeric structure.
View Article and Find Full Text PDFUltrasound Obstet Gynecol
January 2008
Department of Obstetrics and Gynecology, Oulu University Hospital, PL 5000, 90014 University of Oulu, Oulu, Finland.