397 results match your criteria: "90014 University of Oulu[Affiliation]"

EEG spectral changes and onset of burst suppression pattern in propofol/remifentanil anesthesia.

Annu Int Conf IEEE Eng Med Biol Soc

May 2009

Department of Electrical and Information Engineering, BOX 4500, FIN-90014 University of Oulu, Finland.

This paper studies how remifentanil, a commonly used intraoperative opioid, affects the relation of the onset of burst suppression pattern (BSP) and the spectral changes of EEG during anesthesia. The onsets of BSP were detected using both manual and the automatic method proposed from the EEGs of twenty-seven patients who had received different amount of remifentanil with the anesthetic. The spectral changes were determined by calculating the frequency progression patterns of the EEGs.

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To date, haemoglobins (Hbs) have been shown to exist in all kingdoms of life. The least studied and understood groups are plant non-symbiotic haemoglobins (nsHbs) and the recently found plant truncated Hbs (trHbs). From a biotechnological point of view, the best characterized and almost exclusively applied Hb is the bacterial Vitreoscilla haemoglobin (VHb).

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The walls of solid matrix restrict the self-diffusion of a fluid absorbed in the matrix, and this is reflected in the echo amplitudes measured by PGSTE NMR. Hence, the pore size distribution of the matrix can be extracted from the echo amplitudes. We demonstrate that, when both liquids and gases (water and methane in this case) are used as probe fluids, the scale of the dimensions observable by PGSTE NMR may be over 4 orders of magnitude.

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Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity.

Respir Res

December 2008

Institute of Clinical Medicine, Department of Internal Medicine, Centre of Excellence in Research, P O Box 5000, 90014 University of Oulu, Oulu, Finland.

Background: Oxidative stress plays a potential role in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Glutathione S-transferases (GSTs) detoxify toxic compounds in tobacco smoke via glutathione-dependent mechanisms. Little is known about the regulation and expression of GSTs in COPD lung and their presence in airway secretions.

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Current rates of climate change are unprecedented, and biological responses to these changes have also been rapid at the levels of ecosystems, communities, and species. Most research on climate change effects on biodiversity has concentrated on the terrestrial realm, and considerable changes in terrestrial biodiversity and species' distributions have already been detected in response to climate change. The studies that have considered organisms in the freshwater realm have also shown that freshwater biodiversity is highly vulnerable to climate change, with extinction rates and extirpations of freshwater species matching or exceeding those suggested for better-known terrestrial taxa.

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Evidence for gamma-actin as a Z disc component in skeletal myofibers.

Exp Cell Res

January 2009

Institute of Biomedicine, Department of Anatomy and Cell Biology, P.O. Box 5000 (Aapistie 7), FIN-90014 University of Oulu, Finland.

We investigated the targeting of the gamma-actin isoform in skeletal myofibers. For this purpose we used expression vectors to produce green fluorescent protein (GFP-) as well as myc-tagged gamma-actin in rat flexor digitorum brevis myofibers. We found that the gamma-actin fusion proteins accumulated into Z discs but not beneath the sarcolemma.

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Article Synopsis
  • Odontoblasts are essential for creating dentin through the production of organic matrix and mineralization, and new techniques have been developed to study both mature and newly formed odontoblasts.
  • A comparison of gene expression profiles between native and cultured odontoblasts revealed notable similarities, particularly in the expression levels of genes related to neuronal proteins.
  • Findings indicated that cultured odontoblasts closely mimic the gene expression patterns of native ones, highlighting their potential for in vitro research and supporting the idea that odontoblasts may function as sensory cells.
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Lysyl hydroxylase 3 (LH3, encoded by PLOD3) is a multifunctional enzyme capable of catalyzing hydroxylation of lysyl residues and O-glycosylation of hydroxylysyl residues producing either monosaccharide (Gal) or disaccharide (Glc-Gal) derivatives, reactions that form part of the many posttranslational modifications required during collagen biosynthesis. Animal studies have confirmed the importance of LH3, particularly in biosynthesis of the highly glycosylated type IV and VI collagens, but to date, the functional significance in vivo of this enzyme in man is predominantly unknown. We report here a human disorder of LH3 presenting as a compound heterozygote with recessive inheritance.

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Background: Extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38-MAPK) have been shown to regulate various cellular processes, including cell growth, proliferation, and apoptosis in the heart. However, the function of these signaling pathways in the control of cardiac contractility is unclear. Here, we characterized the contribution of ERK1/2 and p38-MAPK to the inotropic effect of endothelin-1 (ET-1).

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Speech perception and auditory performance in finnish adult cochlear implant users.

Cochlear Implants Int

June 2005

Department of Finnish, Information Studies and Logopedics, PO Box 1000, FIN-90014 University of Oulu, Finland.

Objective: This study aimed at investigating the association between speech perception and categories of auditory performance (mCAP) in everyday life for adult cochlear implant users.

Design: A prospective repeated measures design over a two-year follow-up period was used.

Methods: The speech perception and auditory performance of 19 Finnish-speaking adults were assessed before implantation and 1, 3, 6, 12 and 24 months after switching on the implant.

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Wnt-11 signaling leads to down-regulation of the Wnt/beta-catenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells.

Exp Cell Res

August 2008

Oulu Centre for Cell-Matrix Research, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, P.O.B. 5000, 90014 University of Oulu, Finland.

The Wnt family of glycoprotein growth factors controls a number of central cellular processes such as proliferation, differentiation and ageing. All the Wnt proteins analyzed so far either activate or inhibit the canonical beta-catenin signaling pathway that regulates transcription of the target genes. In addition, some of them activate noncanonical signaling pathways that involve components such as the JNK, heterotrimeric G proteins, protein kinase C, and calmodulin-dependent protein kinase II, although the precise signaling mechanisms are only just beginning to be revealed.

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Present knowledge on plant non-symbiotic class-1 (Hb1) and truncated (TrHb) haemoglobin genes is almost entirely based on herbaceous species while the corresponding tree haemoglobin genes are not well known. The function of these genes has recently been linked with endosymbioses between plants and microbes. In this work, the coding sequences of hybrid aspen (Populus tremulaxtremuloides) PttHb1 and PttTrHb were characterized, indicating that the key residues of haem and ligand binding of both genes were conserved in the deduced amino acid sequences.

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Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.

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Intralipid is a well-known emulsion used as a tissue-simulating phantom in developing optical imaging and diagnostic techniques for medical applications. The optical coherence tomography (OCT), pulsed photoacoustic (PA), and time-of-flight (TOF) techniques were used to detect glucose-induced changes in the optical properties of Intralipid. A comparison of the applicability of these techniques to register changes in the scattering properties of Intralipid samples showed that OCT is the most effective method, whereas the sensitivity of the PA technique was less pronounced.

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Purpose: To study the association between age at onset and the clinical picture of schizophrenia in an unselected young birth cohort.

Subjects And Methods: The study sample consists of 98 (64 males and 34 females) individuals with DSM-III-R schizophrenia collected from the Northern Finland 1966 birth cohort. Firstly, subjects were divided into very early- and young-onset subgroups by using the median age at onset (22 years in males and 20 in females), as a cut-off point.

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Improved production of human type II procollagen in the yeast Pichia pastoris in shake flasks by a wireless-controlled fed-batch system.

BMC Biotechnol

March 2008

Bioprocess Engineering Laboratory, Dept, of Process and Environmental Engineering, University of Oulu, P.O. Box 4300, FIN-90014 University of Oulu, Finland.

Background: Here we describe a new technical solution for optimization of Pichia pastoris shake flask cultures with the example of production of stable human type II collagen. Production of recombinant proteins in P. pastoris is usually performed by controlling gene expression with the strong AOX1 promoter, which is induced by addition of methanol.

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Objective: To assess the specificity and sensitivity of autoantibodies binding to citrullinated carboxyterminal telopeptides of types I and II collagens in an early arthritis series.

Methods: A cohort of 146 patients from the Kuopio 2000 Arthritis Survey having RA, AS, PsA, ReA, uSpA or undifferentiated arthritis were studied. Autoantibodies binding citrullinated types I and II carboxytelopeptides were measured in two different inhibition ELISA assays.

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Veterinary professionals working in partnership with other competent persons are essential for a successful animal care and use programme. A veterinarian's primary responsibilities are defined by their own professional regulatory bodies, but in this area of work there are further opportunities for contribution, which will assist in safeguarding the health and welfare of animals used in research. These guidelines are aimed not only at veterinarians to explain their duties, and outline the opportunities to improve the health and welfare of animals under their care, but also at employers and regulators to help them meet their responsibilities.

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Wolbachia transmission dynamics in Formica wood ants.

BMC Evol Biol

February 2008

Department of Biology, PO Box 3000, 90014 University of Oulu, Finland.

Background: The role of Wolbachia endosymbionts in shaping the mitochondrial diversity of their arthropod host depends on the effects they have on host reproduction and on the mode of transmission of the bacteria. We have compared the sequence diversity of wsp (Wolbachia surface protein gene) and the host mtDNA in a group of Formica ant species that have diverged approximately 0.5 million years ago (MYA).

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1. In scramble competition all individuals suffer equally from competition, whereas in contest competition some individuals outperform the others. Generally, larger individuals gain asymmetric advantage in competition over smaller ones.

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The flexible catalytic loop, loop-6, of TIM has evolved to preferably be open in the unliganded state and to preferably be closed in the liganded state. The N-terminal and C-terminal hinges of this loop are important for its opening/closing mechanism. In this study, a small conserved C-terminal hinge residue, Ala178, has been mutated into a residue with a larger side chain, Leu178.

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Delayed neuromotor development carries an increased risk of developing schizophrenia, and some authors have assumed that risk factors for schizophrenia such as delayed development are also prognostic indicators for patients with established illness. In those who do develop schizophrenia, it is not clear if these same early developmental markers influence the outcome of illness. Our aim was to examine the association between infant developmental milestones and a range of outcomes in patients with schizophrenia.

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Bis(tetra-phenyl-phospho-nium) di-μ-iodido-bis[di-iodido-tellurate(II)].

Acta Crystallogr Sect E Struct Rep Online

November 2008

Department of Chemistry, P.O. Box 3000, FI-90014 University of Oulu, Finland.

The structure of the title compound, (C(24)H(20)P)(2)[Te(2)I(6)], is composed of discrete PPh(4) (+) cations and centrosymmetric [Te(2)I(6)](2-) anions. The tellurium(II) atom shows a sligthly distorted square-planar TeI(4) geometry and is coordinated to two bridging and two terminal iodine atoms. The planar [Te(2)I(6)](2-) ions are isolated by the cations and no inter-molecular tellurium-halogen or halogen-halogen inter-actions are present.

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The title compound, [HgCl(2)(C(7)H(8)S)](n), was isolated from the reaction of MeSPh with HgCl(2). The Hg(II) atom has a distorted tetra-hedral geometry and is coordinated by one S atom and three Cl atoms. Two of the Cl atoms act as bridging ligands between the Hg atoms, forming a two-dimensional polymeric structure.

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