Laser writing of metal-oxide doped graphene films for tunable sensor applications.

Flexible and wearable devices play a pivotal role in the realm of smart portable electronics due to their diverse applications in healthcare monitoring, soft robotics, human-machine interfaces, and artificial intelligence. Nonetheless, the extensive integration of intelligent wearable sensors into mass production faces challenges within a resource-limited environment, necessitating low-cost manufacturing, high reliability, stability, and multi-functionality. In this study, a cost-effective fiber laser direct writing method (fLDW) was illustrated to create highly responsive and robust flexible sensors.

repeat expansion creates the unstable folate-sensitive fragile site FRA9A.

The hyper-unstable Chr9p21 locus, harbouring the interferon gene cluster, oncogenes and , is linked to multiple diseases. (GGGGCC)n expansions (Exp) are associated with incompletely penetrant amyotrophic lateral sclerosis, frontotemporal dementia and autoimmune disorders. Exp patients display hyperactive cGAS-STING-linked interferon immune and DNA damage responses, but the source of immunostimulatory or damaged DNA is unknown.

Photoredox-Catalyzed Decarboxylation of Oxetane-2-Carboxylic Acids and Unique Mechanistic Insights.

Oxetanes are valuable motifs in medicinal chemistry applications, with demonstrated potential to serve as bioisosteres for an array of functional groups. Through the visible-light-mediated photoredox hydrodecarboxylation of 2-aryl oxetane 2-carboxylic acids this work enables access to the products of a [2+2]-photocycloaddition between alkenes and aryl aldehydes without the challenges associated with a traditional UV-light-mediated Paternò-Büchi reaction. Investigation into the hydrodecarboxylation mechanism reveals substrate-dependent modes of initiation under the conditions reported herein.

Navigating challenges and cultivating connections: Faculty experiences teaching RN-BSN students.

Background: Success in completing an RN to BSN program largely depends on program quality, flexibility, and accessibility, as well as faculty ability to help students navigate several complex factors. Research specific to the RN-BSN student experience suggests that faculty teaching in RN-BSN programs must be respectful of diverse learners' needs, mindful to avoid bias and reduce stigma, and capable in creating equitable learning spaces. Faculty must also make content relevant to support immediate use by students in the workplace.

Does Annulus Fibrosus Lamellar Adhesion Testing Require Preconditioning?

The interlamellar matrix (ILM), located between the annular layers of the intervertebral disc (IVD), is an adhesive component which acts to resist delamination. Investigating the mechanical properties of the ILM can provide us with valuable information regarding risk of disc injury; however given its viscoelastic nature, it may be necessary to conduct preconditioning on tissue samples before measuring these ILM properties. Therefore, the aim of this study was to optimize mechanical testing protocols of the ILM by examining the effect of preconditioning on stiffness and strength of this adhesive matrix.

Silicon-based Linkers for Tunable Acid-Sensitive Drug Release from Polymeric Nanoparticles.

Active Pharmaceutical Ingredients (APIs) may benefit from a carrier to improve their pharmacokinetic and pharmacodynamic properties. Core-crosslinked polymeric micelles (CCPMs) are carriers for hydrophobic small molecule APIs. In CCPMs, APIs are generally covalently coupled to the core of the micelles by use of a linker, which can be tailored to adjust the release rate of the API.

Heat strain in road construction workers during the summer in New Mexico: a preliminary study.

Unlabelled: In the summer season, road construction workers perform physically demanding tasks outdoors, placing them at greater risk for exertional heat illness conditions. Assessing core temperature (Tcore) is critical as it serves as a key indicator of heat strain and helps to estimate the risk of heat-related illness. Despite the increased risk of hyperthermia, previous research has not assessed Tcore in road construction workers in the United States during summer work.

Constrained β-Hairpins Targeting the EphA4 Ligand Binding Domain.

The activity of the receptor tyrosine kinase EphA4 has been implicated in several pathologies including oncology (gastric and pancreatic cancers) and neurodegenerative diseases (amyotrophic lateral sclerosis and Alzheimer's disease). However, advances in validating EphA4 as a possible drug target have been limited by the lack of suitable pharmacological inhibitors. Recently, we reported on the design of potent EphA4 agonistic agents targeting its ligand binding domain (LBD).

Polyoxometalates as advanced-performance anions for ∼ Dy(III) single-ion magnets.

We enhance single-ion magnet (SIM) magnetisation reversal barriers by engineering the second coordination sphere, substituting conventional small monoanions with a bulky polyoxometalate (POM) trianion. Importantly, our approach serves as a model for creating new high-performance multifunctional hybrid materials.

Graph theory approaches for molecular dynamics simulations.

Graph theory, a branch of mathematics that focuses on the study of graphs (networks of nodes and edges), provides a robust framework for analysing the structural and functional properties of biomolecules. By leveraging molecular dynamics (MD) simulations, atoms or groups of atoms can be represented as nodes, while their dynamic interactions are depicted as edges. This network-based approach facilitates the characterization of properties such as connectivity, centrality, and modularity, which are essential for understanding the behaviour of molecular systems.

High-Temperature Polymorphism and Band-Gap Evolution in BaZrS.

Barium zirconium trisulfide (BZS) is a three-dimensional (3D) perovskite with optoelectronic properties suitable for photovoltaic (PV) and light-emitting diode (LED) applications that is conventionally reported in the orthorhombic (62) symmetry. Synchrotron X-ray diffraction, thermal analysis, and Raman and absorption spectroscopy revealed three high-temperature polymorphs that appear when BZS is heated in air prior to complete oxidation (BaZrS + 5O → BaSO + ZrO + 2SO↑) at 700 °C with the approximate stability ranges: BaZrS IV (62)T < 400 °CBaZrS III (63)400 °C ≤ T ≤ 500 °CBaZrS II14/ (140)500 °C ≤ T ≤ 700 °CDifferential scanning calorimetry (DSC) revealed exothermic features accompanying the IV → III and III → II phase changes. Furthermore, the direct band gap varied inversely with temperature with distinct energies for each polymorph (1.

Subclinical bacteriuria and surgical-site infection in 140 dogs with orthopedic and neurological conditions.

Objectives: This study aimed to determine the prevalence, risk factors, and types of bacterial isolates associated with subclinical bacteriuria (SBU) in dogs with reduced mobility; and to explore the influence of SBU on surgical-site infection (SSI) in dogs treated surgically for their conditions.

Animals: We studied 140 client-owned dogs.

Procedure: Medical records of dogs with orthopedic and neurological conditions from 3 academic referral hospitals were reviewed.

The structural discrepancy between the ability of fructan and arabinogalactan to cure acute pharyngitis in Hosta plantaginea (Lam.) Aschers flowers.

The flowers of Hosta plantaginea (Lam.), a traditional Chinese medicine, is utilized for the treatment of sore throat, aphonia, and cough alleviation. The polysaccharides HPFP-1 and HPFP-2 were separated from these plants through water-soluble alcohol precipitation and column chromatography.

People who approve of one's physical activity vs. people who are influential: A randomized cross-over experiment to compare normative referent elicitation procedures.

Objectives: To compare injunctive norm scores assessed based on Ajzen's (2002) original normative referent elicitation method (e.g., norms from those who approve/disapprove of physical activity) and a revised method (e.

CT and MRI bimodal radiomics for predicting EGFR status in NSCLC patients with brain metastases: A multicenter study.

Background: Leveraging the radiomics information from non-small cell lung cancer (NSCLC) primary lesion and brain metastasis (BM) to develop and validate a bimodal radiomics nomogram that can accurately predict epidermal growth factor receptor (EGFR) status.

Methods: A total of 309 NSCLC patients with BM from three independent centers were recruited. Among them, the patients of Center I were randomly allocated into the training and internal test cohorts in a 7:3 ratio.

Review of the Mexican species of Disholcaspis Dalla Torre & Kieffer with the description of eleven new species.

Disholcaspis Dalla Torre & Kieffer, 1910 is reviewed for the first time in Mexico. A total of 23 species have been studied, 12 previously known species, 11 new species, and one new synonym: D. brasoae Cuesta-Porta, sp.

Compsanthias, new genus of Pacific Anthiadidae (Teleostei).

Compsanthias new genus is described for Anthias ventralis Randall (type species) and A. hawaiiensis Randall, which had been previously classified in the genus Pseudanthias Bleeker. Compsanthias is distinguished from other anthiadid genera in having the following combination of characters: dorsal-fin rays X,16-18, usually X,17; anal-fin rays III,9-10, usually III,9; pectoral-fin rays 14-16, usually 15, most rays branched; branched caudal-fin rays 7+6; tubed scales in lateral series 39-46.

Implementing differential recovery corrections enhances accuracy of mass balances on microplastics in wastewater treatment.

This study examined the impact of using different analytical recovery practices to correct MP concentrations on the performance of count and mass balances of primary wastewater settling. Spiking tests using standard MPs were conducted to evaluate the influence of MP size and sample type on recovery. The derived recovery values were then used to correct MP concentrations and loads in a full-scale primary treatment facility.

Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia.

For cystic fibrosis patients, a lung-targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality. However, mucus in the airways and cell entry pose huge delivery barriers for local gene therapy. Here, we used phage display technology to select for and identify mucus- and cell-penetrating peptides against primary human bronchial epithelial cells from cystic fibrosis patients cultured at the air-liquid interface.

Reactive carbon capture using electrochemical reactors.

The electrolytic upgrading of CO presents a promising strategy to mitigate global CO emissions while generating valuable carbon-based products such as carbon monoxide, formate, and ethylene. However, the adoption of industrial-scale CO electrolyzers is hindered by the high energy and capital costs associated with the purification and pressurization of captured CO prior to electrolysis. One promising solution is "reactive carbon capture," which involves the electrolytic conversion of the eluent from CO capture units, or the "reactive carbon solution," directly into valuable products.

Hospital administrators as forgotten partners in rare disease care: a call to action by the international hospital federation's global rare pediatric disease network.

Background: The global public health burden of rare diseases has become an increasingly discussed topic, and its societal impact cannot be overstated. While it may seem counterintuitive to discuss broad healthcare and public health impact in the context of rarity, taken together, over 400 million people worldwide are estimated to live with a rare disease. Over half of people living with a rare disease are children.

Transforming community-based primary health care delivery through comprehensive performance measurement and reporting: examining the influence of context.

Background: Community-based primary health care represents various community-based health care (CBPHC) models that incorporate health promotion and community development to deliver first-contact health services. Learning health systems (LHSs) are essential for improving CBPHC in which feedback from relevant stakeholders is used to continuously improve health systems with the goal of achieving population health and health equity. Performance reporting is one way to present data to clinicians and decision makers to facilitate a process of reflection, participation, and collaboration among partners to improve CBPHC.

A scoping review on pediatric sepsis prediction technologies in healthcare.

This scoping review evaluates recent advancements in data-driven technologies for predicting non-neonatal pediatric sepsis, including artificial intelligence, machine learning, and other methodologies. Of the 27 included studies, 23 (85%) were single-center investigations, and 16 (59%) used logistic regression. Notably, 20 (74%) studies used datasets with a low prevalence of sepsis-related outcomes, with area under the receiver operating characteristic scores ranging from 0.