Experimental Study of the Tensile Behavior of Structures Obtained by FDM 3D Printing Process.

Fused Deposition Modelling (FDM) is one of the layer-based technologies that fall under the umbrella term "Additive Manufacturing", where the desired part is created through the successive layer-by-layer addition process with high accuracy using computer-aided design data. Additive manufacturing technology, or as it is commonly known, 3D (three-dimensional) printing, is a rapidly growing sector of manufacturing that is incorporated in automotive, aerospace, biomedical, and many other fields. This work explores the impact of the Additive Manufacturing process on the mechanical proprieties of the fabricated part.

Volatile Composition, Antimicrobial Activity, and In Vitro Innate Immunomodulatory Activity of (L.) Moench Essential Oils.

(L.) Moench is a medicinal plant commonly used for the treatment of upper respiratory tract infections, the common cold, sore throat, migraine, colic, stomach cramps, and toothaches and the promotion of wound healing. Based on the known pharmacological properties of essential oils (EOs), we hypothesized that EOs may contribute to these medicinal properties.

Allostatic load in the US general population: Race and educational intersection.

Objectives: Educational attainment is a protective factor against poor health, but high educational attainment has a weaker effect on black people than on white people; this pattern has been called marginalization-related diminished returns (MDRs). Using a national sample of white people and black people 25 years and above, this study estimates the association between high educational attainment and allostatic load between black people and white people, and within each group.

Study Design: This cross-sectional study uses data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2016, including 2761 black people and 7058 white people.

Nursing students' perceived attitudes toward addressing sexual health in their future profession: A longitudinal quantitative study.

Background: Sexual health is a necessary component of human wellbeing. Nurses espouse holistic care but in practice often overlook a person's sexual health. Disparities linked to sexual health persist nationally and globally, including those among gender and sexual minorities.

Six Cs of pandemic emergency management: A case study of Taiwan's initial response to the COVID-19 pandemic.

A review of the disaster literature indicates that emergency responses to pandemics are often understudied; the current COVID-19 crisis provides an important opportunity to improve awareness and understanding about this and other contagious and disruptive diseases. With this in mind, this study examines Taiwan's response to COVID-19 because it was successful in spite of a high probability of contagion. The paper first explores the assertion that cognition, communication, collaboration, and control are vital for effective disaster response; it then indicates the need to consider two additional Cs: confidence (trust of government's competency) and coproduction (public participation in disaster transmission prevention).

Do detection-based warning strategies improve vehicle yielding behavior at uncontrolled midblock crosswalks?

Pedestrians being the most vulnerable road users account for a large proportion of injuries and fatalities from road traffic crashes. Pedestrians are involved in around one-third of the whole fatalities coming from the road traffic crashes in the state of Qatar. In areas with uncontrolled midblock crosswalks, it is very crucial to improve drivers' alertness and yielding behavior.

Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice.

Background: Neuroinflammation and accumulation of β-amyloid (Aβ) play a significant role in the onset and progression of Alzheimer's disease (AD). Our previous study demonstrated that signal transducer and activator of transcription-3 (STAT3) plays a major role in neuroinflammation and amyloidogenesis.

Methods: In the present study, we investigated the inhibitory effect of bee venom phospholipase A2 (bvPLA2) on memory deficiency in Tg2576 mice, which demonstrate genetic characteristics of AD and the mechanism of its action at the cellular and animal level.

Effects of infant transportation on lower extremity joint moments: Baby carrier versus carrying in-arms.

Background: The act of babywearing is recognizably a task of load carriage and has gained popularity among millennial caregivers.

Research Question: The implications of babywearing on lower extremity joint moments of the caregiver are still unknown during prolonged transport and a direct comparison of babywearing to carrying an infant in-arms has not been previously conducted.

Methods: Eighteen females participated in this study by performing 3 conditions: a) 3 min walking unloaded (UL), b) 15 min walking while carrying a mannequin infant in-arms (IA), and c) 15 min walking while wearing a mannequin infant in an anteriorly positioned baby carrier (BC).

Summary results of the 2014-2015 DARPA Chikungunya challenge.

Background: Emerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of emerging epidemics and their severity are critical to minimizing subsequent mortality, morbidity, and economic loss. The recent introduction of chikungunya and Zika virus to the Americas underscores the need for better methods for disease surveillance and forecasting.

MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity Direct Binding to the STAT3 DNA-Binding Domain.

Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for drug discovery, there has been a growing interest in targeting the DNA-binding domain (DBD) of the protein.

Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3.

Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to long-term joint damage. Signal transducer and activator of transcription 3 (STAT3)-targeted small molecules have shown promise as therapeutic drugs for treating RA. We previously identified (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), a tyrosine-fructose Maillard reaction product, as a small molecule with potent anti-inflammatory and anti-arthritic properties, mediated through the inhibition of STAT3 activation.

Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway.

Background: Accumulation of beta-amyloid and neuroinflammation trigger Alzheimer's disease. We previously found that lipopolysaccharide (LPS) caused neuroinflammation with concomitant accumulation of beta-amyloid peptides leading to memory loss. A variety of anti-inflammatory compounds inhibiting nuclear factor kappaB (NF-κB) activation have showed efficacy to hinder neuroinflammation and amyloidogenesis.