60 results match your criteria: "6572University of Pennsylvania[Affiliation]"

The purpose of this study was to examine changes in and predictors of perceived tangible social support over a 2-year period among older adults new to LTSS. Linear mixed effects models were used to model repeated measures of tangible social support as a function of LTSS type [NH, AL, HCBS], personal, clinical, and health-related quality of life variables. AL residents reported greater initial tangible social support, but NH and HCBS residents improved more over time.

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Background: Informed consent requires preoperative discussion of surgical risks, complications, and alternative treatment options. Allegations of incomplete informed consent are common in the field of otolaryngology.

Objectives: Analyze outcomes and case variables in cases of alleged informed consent failure involving otolaryngologists.

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Machine Learning Radiomics Model for External and Internal Respiratory Motion Correlation Prediction in Lung Tumor.

Technol Cancer Res Treat

December 2022

Radiotherapy Physics and Technology Center, Cancer Center, 34753West China Hospital, Sichuan University, Chengdu, China.

The complexity and specificity of lung tumor motion render it necessary to determine the external and internal correlation individually before applying indirect tumor tracking. However, the correlation cannot be determined from patient respiratory and tumor clinical characteristics before treatment. The purpose of this study is to present a machine learning model for an external/internal correlation prediction that is based on computed tomography (CT) radiomic features.

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Depressive Symptom Trajectories and Cognition Among Older American Couples: A Dyadic Perspective.

J Aging Health

March 2023

Department of Political Science, Department of Statistics, and School of Education, 1177Iowa State University, Ames, IA, USA.

Objectives: This study examined whether trajectories of depressive symptoms of one spouse are associated with the other spouse's memory.

Methods: Longitudinal data from the Health and Retirement Study (2004-2016) were used ( = 5690 heterosexual couples). Latent-class growth analysis and structural equation models examined the actor and partner effects of depressive symptom trajectories on memory.

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A National Cancer Database Analysis of Sinonasal Malignant Myoepithelial Carcinoma Outcomes.

Am J Rhinol Allergy

January 2023

Department of Otorhinolaryngology - Head and Neck Surgery, 6572University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

Objectives: Myoepithelial carcinoma (MECA) is a rare salivary gland tumor that can occur in the sinonasal cavity with poor outcomes. There are limited data on sinonasal outcomes to guide management. We sought to use the National Cancer Database (NCDB) to better define treatment outcomes in MECA.

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Introduction: Cyclin-dependent-kinase 4/6(CDK4/6) inhibitors are widely used as a first-line systemic treatment for patients with hormone receptor-positive, human epidermal growth factor receptor-2 negative metastatic breast cancer. Although many patients with metastatic breast cancer require palliative radiotherapy (RT), there are limited data on the safety of combining a CDK4/6 inhibitor with palliative RT.

Case Report: Presented is a case of acute high-grade radiation dermatitis with low-dose palliative RT following administration of palbociclib.

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Differences in cultural orientations, such as interdependent and independent self-construals, may influence social anxiety disorder (SAD) symptom presentations. However, prior research on the association between interdependent/independent self-construals and SAD was limited to non-clinical samples. Using a treatment-seeking population with clinical levels of anxiety, the current study extends prior research by examining whether the relationship between interdependent/independent self-construals and SAD is specific to SAD or indicative of a broader relationship with anxiety or depression more generally.

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Sinonasal Acinic Cell Carcinoma: A Review of the National Cancer Database.

Am J Rhinol Allergy

November 2022

Department of Otorhinolaryngology - Head and Neck Surgery, 6572University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.

Background: Acinic cell carcinoma (ACC) is a salivary gland malignancy that rarely can involve the sinonasal cavity. There are limited outcomes data available to guide management.

Objective: We sought to use the National Cancer Database (NCDB) to characterize treatment outcomes in sinonasal ACC.

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In a growing body of literature, poor sleep quality has been associated with externalizing problems. In adults, anxiety was found to mediate the relationship, and callous-unemotional (CU) traits were found to moderate it. We sought to examine these relationships in a child population.

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In this paper, we study the incidence of COVID-19 and the associated fatality with altitude using high frequency, district level data from India. To understand the implications of the nationwide lockdown after the outbreak, we use data for about four months- two from the lockdown period starting from March 25 till May 31, 2020 and about two months after unlocking was initiated (June 1-July 26, 2020). The multivariate regression result indicates slower growth in average rate of infection during the lockdown period in hilly regions, the gains of which attenuated after the unlocking was initiated.

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Introduction: Memantine is used for neurocognitive protection in patients undergoing cranial radiotherapy for central nervous system tumors and is reported to be well-tolerated.

Case Report: Presented is a case of memantine-induced altered mental status requiring an intensive care unit admission. An 18-year-old male with relapsed, progressive medulloblastoma presented with severe altered mental status shortly after the first fraction of palliative whole brain radiotherapy.

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, or the criminal exploitation of a child's personal data, poses serious risks and challenges for youth in foster care. Despite the 10-year history of a federal mandate requiring state child welfare agencies to conduct annual credit checks for adolescent foster youth (42 U.S.

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Persons with hematologic malignancies have a high symptom burden throughout the illness journey. Coping skills interventions effectively reduce fatigue for other cancer patients. The purpose of this systematic review is to identify if coping interventions can reduce fatigue in patients with hematologic malignancies.

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Article Synopsis
  • - Family caregivers (FCs) of cancer patients face significant challenges in managing pain, which includes issues with communication and teamwork with healthcare providers, as well as personal and patient-related concerns.
  • - A study involving interviews with 40 FCs revealed that inadequate information and communication from healthcare teams hinder effective pain management (PM), while FCs struggle with their own fears, responsibilities, and lack of knowledge.
  • - The findings highlight the necessity for training programs for FCs in PM, alongside improved clinical guidelines to enhance communication and support from healthcare providers.
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Perspectives of State Association Leaders During the COVID-19 Pandemic.

Am J Hosp Palliat Care

January 2023

Department of Biobehavioral and Health Sciences, School of Nursing, Epidemiology and Informatics, Perelman School of Medicine, 6572University of Pennsylvania, Philadelphia, PA, USA.

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Article Synopsis
  • There is significant variability in the severity of post-stroke aphasia, and traditional prediction methods often overlook neurophysiological and genetic factors that could influence recovery.
  • The study aims to determine if a specific genetic variant (ValMet) in the BDNF gene affects aphasia severity and interacts with neuroplasticity indicators to enhance recovery predictions.
  • Results showed that individuals with the ValVal genetic variant had less severe aphasia and exhibited expected age-related effects, while ValMet carriers displayed weaker correlations with neuroplasticity indicators, indicating the genetic variant’s role in recovery outcomes.
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Price transparency is a central component of the shift from volume to value in healthcare delivery. Price transparency in primary care, the most common point of contact with the healthcare system for patients in the U.S.

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While sleep disturbances are common in people living with cognitive impairment, little is known about the influence of evening light exposure on their sleep. The purpose of this study was to examine the relationship between evening light exposure in natural living environment and daytime sleepiness in community residing people living with cognitive impairment. A secondary data analysis was conducted using the baseline data of the Healthy Patterns Clinical Trial.

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Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) research typically requires participants to enroll with a "study partner" (SP). Little is known about what predicts who steps into the SP role or whether the SP's relationship to the participant affects their reports of disease severity. Health and Retirement Study data (HRS), collected prior to the Aging, Demographics and Memory Study (ADAMS), was used to identify sociocultural factors that predict who serves as a SP in ADAMS.

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Purpose: To investigate partisanship in COVID-19 attitudes, and assess partisan or scientific messaging effects on COVID-19 vaccination intentions.

Design: Two-wave survey with two-arm randomized experiment.

Setting: Recruited Pennsylvania residents online.

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This study evaluated how continuities and discontinuities in the intergenerational transmission of maltreatment affect offspring psychopathology. Data from a multigenerational prospective, longitudinal study were used to compare the severity of offspring psychopathology in families with no history of maltreatment () and those in which parents, offspring, or both experienced childhood maltreatment ( and , respectively). Participants included 454 parents ( = 47.

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Objective: Bleeding and thrombosis are common complications during Extracorporeal Membrane Oxygenation (ECMO) support for COVID-19 patients. We sought to examine the relationship between inflammatory status, coagulation effects, and observed bleeding and thrombosis in patients receiving venovenous (VV) ECMO for COVID-19 respiratory failure.

Study Design: Cross-sectional cohort study.

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Patients with obstructive sleep apnea (OSA) are at elevated risk of developing systemic vascular disease and cognitive dysfunction. Here, cerebral oxygen metabolism was assessed in patients with OSA by means of a magnetic resonance-based method involving simultaneous measurements of cerebral blood flow rate and venous oxygen saturation in the superior sagittal sinus for a period of 10 minutes at an effective temporal resolution of 1.3 seconds before, during, and after repeated 24-second breath-holds mimicking spontaneous apneas, yielding, along with pulse oximetry-derived arterial saturation, whole-brain CMRO via Fick's Principle.

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Despite growing recognition of the importance of community-based palliative care, optimizing the use of services continues to be a challenge. Until recently, key barriers were reimbursement and limited access. As services have become increasingly available, engagement of patients and their caregivers has emerged as a major obstacle.

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