Binge alcohol induces NRF2-related antioxidant response in the skeletal muscle of female mice.

Background: Chronic alcohol enhances oxidative stress, but the temporal response of antioxidant genes in skeletal muscle following a binge drinking episode remains unknown.

Methods: Experiment 1: C57BL/6Hsd female mice received an IP injection of saline (CON; n = 39) or ethanol (ETOH; n = 39) (5 g/kg). Gastrocnemius muscles were collected from baseline (untreated; n = 3), CON (n = 3), and ETOH (n = 3) mice every 4 h for 48 h.

Decoding seasonal variability of air pollutants with climate factors: A geostatistical approach using multimodal regression models for informed climate change mitigation.

In response to changes in climatic patterns, a profound comprehension of air pollutants (AP) variability is vital for enhancing climate models and facilitating informed decision-making in nations susceptible to climate change. Earlier research primarily depended on limited models, potentially neglecting intricate relationships and not fully encapsulating associations. This study, in contrast, probed the spatiotemporal variability of airborne particles (CO, CH, SO, and NO) under varying climatic conditions within a climate-sensitive nation, utilizing multiple regression models.

Location selection of field hospitals amid COVID-19 considering effectiveness and fairness: A case study of Florida.

The world has experienced an unprecedented global health crisis since 2020, the COVID-19 pandemic, which inflicted massive burdens on countries' healthcare systems. During the peaks of the pandemic, the shortages of intensive care unit (ICU) beds illustrated a critical vulnerability in the fight. Many individuals suffering the effects of COVID-19 had difficulty accessing ICU beds due to insufficient capacity.

Mealtime alcohol consumption suppresses skeletal muscle mTORC1 signaling in female mice.

Objective: To determine whether alcohol consumed within the meal influences the feeding induced increase in mTORC1 signaling.

Methods: Alcohol provided in the liquid diet was consumed by alcohol naïve, fasted, C57BL/6Hsd female mice and gastrocnemius was collected 1hr after the refeeding. Subsequent experiments determined the extent to which changes in mTORC1 signaling persisted across the day.

Identifying areas of potential critical healthcare shortages: A case study of spatial accessibility to ICU beds during the COVID-19 pandemic in Florida.

Healthcare resource availability is potentially associated with COVID-19 mortality, and the potentially uneven geographical distribution of resources is a looming concern in the global pandemic. Given that access to healthcare resources is important to overall population health, assessing COVID-19 patients' access to healthcare resources is needed. This paper aims to examine the temporal variations in the spatial accessibility of the U.

Spatial accessibility assessment of COVID-19 patients to healthcare facilities: A case study of Florida.

During the COVID-19 pandemic, healthcare facilities worldwide have been overwhelmed by the amount of coronavirus patients needed to be served. Similarly, the U.S.

Population projections for U.S. counties by age, sex, and race controlled to shared socioeconomic pathway.

Small area and subnational population projections are important for understanding long-term demographic changes. I provide county-level population projections by age, sex, and race in five-year intervals for the period 2020-2100 for all U.S.

Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise.

Exercise increases skeletal muscle health in part by altering the types of genes that are transcribed. Previous work suggested that glucocorticoids signal through the protein Regulated in Development and DNA Damage 1 (REDD1) to regulate gene expression following acute aerobic exercise. The present study shows that expression of the core clock gene, Period1, is among those modulated by the glucocorticoid-REDD1 signaling pathway in skeletal muscle.