Demographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York.

Nassau and Suffolk Counties of Long Island, New York are densely populated and contain 34 federally-designated and 449 state-designated Superfund sites, potentially exposing communities to toxic releases. We conducted a distributive justice analysis assessing proximity to Superfund sites, community socio-demographics, and other environmental burdens. Socio-demographic and environmental variables for 665 census tracts were obtained from the United States Census and Environmental Protection Agency's Environmental Justice Screening and Mapping Tool.

Indicators from The Lancet Countdown on Health and Climate Change: Perspectives and Experience of City Leaders from 118 Cities.

Rapid urbanization and escalating climate crises place cities at the critical juncture of environmental and public health action. Urban areas are home to more than half of the global population, contributing ~ 75% of global greenhouse gas emissions. Structured surveys were completed by 191 leaders in city governments and civil society from 118 cities in 52 countries (February-April 2024).

Activity Space Mapping and Pre-Exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Sexual Minority Men in Small Cities and Towns in the United States.

In the US, gay, bisexual, and other sexual minoritized men (GBSMM) remain disproportionately impacted by HIV, and continue to experience unmet needs for pre-exposure prophylaxis (PrEP). A growing body of literature has underscored the need to consider the geographic factors of HIV prevention, particularly beyond administrative boundaries and towards localized spaces that influence the accessibility and utilization of health-promoting resources. Therefore, the purpose of this study is to examine the associations of driving times from activity spaces to PrEP offering facilities and individual PrEP uptake.

On modes of disease transmission and the hidden shape of pandemics: A review of by Joshua Weitz.

The importance of asymptomatic transmission was a key discovery in our efforts to study and intervene in the COVID-19 pandemic. In (Johns Hopkins University Press, 2024), Joshua Weitz uses this aspect of SARS-CoV-2 natural history to discuss many counterintuitive characteristics of the pandemic. In this essay, I engage the arguments in the book, and discuss why asymptomatic transmission is such a critical dimension of the study of infectious diseases.

A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolution.

Different theoretical frameworks have been invoked to guide the study of virus evolution. Three of the more prominent ones are (i) the evolution of virulence, (ii) life history theory, and (iii) the generalism-specialism dichotomy. All involve purported tradeoffs between traits that define the evolvability and constraint of virus-associated phenotypes.

TGV: suite of tools to visualize transmission graphs.

Graph structures are often used to visualize transmission networks generated using genomic epidemiological methods. However, tools to interactively visualize these graphs do not exist. A browser-based tool allowing users to load and interactively visualize transmission graphs was developed in JavaScript.

Association of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system.

Background And Objectives: To examine changes in clerical burden, including daily clerical time, daily after hours Electronic Health Record (EHR) time and EHR frustration between 2018 and 2022 among physician faculty, and identify sociodemographic and occupational correlates of clerical burden with burnout and intent to leave one's job (ILJ).

Methods: An institution-wide survey was sent to all physician faculty at an 8-Hospital Health System in New York City, between July and September 2022. Clerical time, after hours EHR time, practice unloading clerical burden and EHR frustration were assessed using ordinal-scale questions.

Longitudinal analysis of lifestyle risk factors, nutrition status, and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia and Almaty, Kazakhstan: a formative study.

Objective: To quantify and compare concurrent within-person trends in lifestyle risks, nutrition status, and drivers of food choice among urban migrants in Central Asia.

Design: We collected panel data on household structure, drivers of food choice, nutrition knowledge, and diverse measures of nutrition status and lifestyle risk from urban migrants at 0, 3, 6, and 9 months using harmonized methodology in two cities. Trends were analyzed using mixed-effects models and qualitatively compared within and between cities.

Supporting diversity in clinical trials: the equitable breakthroughs in medicine site maturity model.

Background: Among the most powerful barriers to broader inclusion of diverse participants in clinical trials are social determinants of health, trustworthiness of health care providers and research institutions, and competing pressures on potential participants. Nevertheless, current tools to assess organizational capabilities for clinical trial diversity focus primarily on trial infrastructure, rely solely on quantitative self-reported data, and lack meaningful assessment of capabilities related to community engagement.

Methods: The Equitable Breakthroughs in Medicine (EQBMED) initiative developed a holistic, collaborative, site-driven formative model and accompanying assessment to catalog sites' current capabilities and identify opportunities for growth in both conducting industry-sponsored clinical trials and enriching diversity of those trials.

Corporate activities that influence population health: a scoping review and qualitative synthesis to develop the HEALTH-CORP typology.

Introduction: The concept of the commercial determinants of health (CDH) is used to study the actions of commercial entities and the political and economic systems, structures, and norms that enable these actions and ultimately influence population health and health inequity. The aim of this study was to develop a typology that describes the diverse set of activities through which commercial entities influence population health and health equity across industries.

Methods: We conducted a scoping review to identify articles using CDH terms (n = 116) published prior to September 13, 2022 that discuss corporate activities that can influence population health and health equity across 16 industries.

Domestic groundwater wells in Appalachia show evidence of low-dose, complex mixtures of legacy pollutants.

Lack of water quality data for private drinking water sources prevents robust evaluation of exposure risk for communities co-located with historically contaminated sites and ongoing industrial activity. Areas of the Appalachian region of the United States (, Pennsylvania, Ohio and West Virginia) contain extensive hydraulic fracturing activity, as well as other extractive and industrial technologies, in close proximity to communities reliant on private drinking water sources, creating concern over potential groundwater contamination. In this study, we characterized volatile organic compound (VOC) occurrence at 307 private groundwater well sites within Pennsylvania, Ohio, and West Virginia.

A phylogenetics and variant calling pipeline to support SARS-CoV-2 genomic epidemiology in the UK.

In response to the escalating SARS-CoV-2 pandemic, in March 2020 the COVID-19 Genomics UK (COG-UK) consortium was established to enable national-scale genomic surveillance in the UK. By the end of 2020, 49% of all SARS-CoV-2 genome sequences globally had been generated as part of the COG-UK programme, and to date, this system has generated >3 million SARS-CoV-2 genomes. Rapidly and reliably analysing this unprecedented number of genomes was an enormous challenge.

Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to P. falciparum infected mosquito bites.

Background: Measuring malaria transmission intensity using the traditional entomological inoculation rate is difficult. Antibody responses to mosquito salivary proteins like SG6 have been used as biomarkers of exposure to Anopheles mosquito bites. Here, we investigate four mosquito salivary proteins as potential biomarkers of human exposure to mosquitoes infected with P.

Shaping childhood obesity: behavioral and environmental risk factors associated with body mass index trajectories between 2 and 9 years in Samoan children.

Background/objective: Pacific children are at high obesity risk, yet the behavioral and environmental factors that contribute to obesity development in this setting remain poorly understood. We assessed associations between childhood risk factors for obesity with body mass index (BMI) trajectories between ages 2-9 years in Samoa.

Subjects/methods: In a prospective cohort of 485 children from 'Upolu, we measured weight and height at ages 2-4 (2015), 3.

scTML: a pan-cancer single-cell landscape of multiple mutation types.

Investigating mutations, including single nucleotide variations (SNVs), gene fusions, alternative splicing and copy number variations (CNVs), is fundamental to cancer study. Recent computational methods and biological research have demonstrated the reliability and biological significance of detecting mutations from single-cell transcriptomic data. However, there is a lack of a single-cell-level database containing comprehensive mutation information in all types of cancer.

Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification.

Objective: Colorectal cancer (CRC) is conventionally classified as right sided, left sided, and rectal cancer. Clinicopathological, molecular features and risk factors do not change abruptly along the colorectum, and variations exist even within the refined subsites, which may contribute to inconsistencies in the identification of clinically relevant CRC biomarkers. We generated a CRC metabolome map to describe the association between metabolites, diagnostic and survival heterogeneity in cancers of different subsites of the colorectum.

Daily motor vehicle traffic volume and other risk factors associated with road deaths in U.S. counties.

Introduction: Road death risk is often characterized as deaths per volume of traffic in geographic regions, the denominator in miles or kilometers supposedly indicative of the magnitude of risk exposure. This paper reports an examination of the differences in the predictive value of factors hypothesized to influence traffic volume and road death risk.

Method: The association of 11 risk factors in U.

Engineering Principles and Bioengineering in Global Health.

Medical technology plays a significant role in the reduction of disability and mortality due to the global burden of disease. The lack of diagnostic technology has been identified as the largest gap in the global health care pathway, and the cost of this technology is a driving factor for its lack of proliferation. Technology developed in high-income countries is often focused on producing high-quality, patient-specific data at a cost high-income markets can pay.

CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study.

1,4-Dioxane (DX), an emerging water contaminant, is classified as a Group 2B liver carcinogen based on animal studies. Understanding of the mechanisms of action of DX liver carcinogenicity is important for the risk assessment and control of this environmental pollution. Previous studies demonstrate that high-dose DX exposure in mice through drinking water for up to 3 months caused liver mild cytotoxicity and oxidative DNA damage, a process correlating with hepatic CYP2E1 induction and elevated oxidative stress.

Exploring social activity patterns among community-dwelling older adults in South Korea: a latent class analysis.

Background: With the trend of digitalization, social activities among the older population are becoming more diverse as they increasingly adopt technology-based alternatives. To gain a comprehensive understanding of social activities, this study aimed to identify the patterns of digital and in-person social activities among community-dwelling older adults in South Korea, examine the associated factors, and explore the difference in depressive symptoms by the identified latent social activity patterns.

Methods: Data were extracted from a nationwide survey conducted with 1,016 community-dwelling older adults (mean age 68.

Disability severity and risk of new or recurrent intimate partner violence - Evidence from a cohort study in rural Pakistan.

Background: People with disabilities are more likely to experience intimate partner violence (IPV) than those without. Most research examining the relationship between disability and IPV, however, is cross-sectional and approaches disability as a binary variable. This relationship is also important to consider in a South Asian context, where it may be affected by cultural norms surrounding IPV, and resources for people with disabilities.

Retinal integrity in human babesiosis: a pilot study.

Background: Prior case reports and animal studies have reported on potential ophthalmologic complications of babesiosis, but this issue has not previously been addressed in a cohort of patients with babesiosis. This cross-sectional descriptive pilot study evaluated the retinas of patients with acute babesiosis to determine if retinal abnormalities are a feature of the disease.

Methods: We screened all patients admitted to Yale New Haven Hospital with laboratory confirmed babesiosis during the summer of 2023 and obtained informed consent.