2 results match your criteria: "6 Center for Pulmonary Functional Imaging.[Affiliation]"
Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality.
Am J Respir Crit Care Med
July 2019
1 Pulmonary and Critical Care Division.
Article Synopsis
- Interstitial lung abnormalities (ILA) are detected via chest CT scans and may indicate early pulmonary fibrosis; the study investigates their patterns in relation to disease progression and mortality risk.
- An analysis of 5,320 individuals revealed that 10% had ILA, with 73% of these showing progression over five years, influenced by factors like age and genetic makeup.
- Certain imaging patterns, especially definitive fibrosis, significantly predicted both progression of ILA and increased risk of death, highlighting the importance of CT findings in patient prognosis.
Rationale: Galectin-3 (Gal-3) has been implicated in the development of pulmonary fibrosis in experimental studies, and Gal-3 levels have been found to be elevated in small studies of human pulmonary fibrosis.
Objectives: We sought to study whether circulating Gal-3 concentrations are elevated early in the course of pulmonary fibrosis.
Methods: We examined 2,596 Framingham Heart Study participants (mean age, 57 yr; 54% women; 14% current smokers) who underwent Gal-3 assessment using plasma samples and pulmonary function testing between 1995 and 1998.