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Development and application of a novel UV method for the analysis of ascorbic acid.
J Pharm Biomed Anal
January 2005
Research and Development, Toronto Institute of Pharmaceutical Technology, 55 Town Center Court-Suite 200, Toronto, Ont., Canada M1P 4X4.
A UV method for the analysis of ascorbic acid with methanol as solvent to prepare a sample has been developed and applied. The effect of copper(II) concentrations on the oxidation of ascorbic acid in aqueous solution has been studied in detail, and the regularities of ascorbic acid oxidation in methanol, USP phosphate buffer (pH 2.50) and de-ionized water have been found.
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