Mechanical resistance of a mandibular first molar under the influence of different endodontic access cavity design: a 3D finite element analysis study.

Biomechanical properties of a mandibular first molar with different cavity designs [traditional access cavities (TEC-I & TEC-II), ninja access cavity (NEC), conservative access cavity (CEC), truss access cavity (Tr-EC), caries-driven access cavity (Cd-EC), caries-driven truss access cavity (Cd-TrEC)] were compared using finite element (FE) analysis. Models were subjected to three different loads. The highest stress distribution was observed on the enamel surface of the Cd-EC design and the dentin surface of the TEC-II.

Carbazole-Bismaleimide Based Hyper-Cross-Linked Porous Organic Polymer for Efficient Iodine Capture.

Radioactive iodine, a key waste product of nuclear energy, has been a significant concern among nuclear materials because of its high volatility and its ability to easily enter the human metabolism. Porous materials containing a large number of N-heterocyclic units such as carbazole in the skeletons use as effective adsorbents showing high iodine capture capacities. Herein, a new carbazole-bismaleimide-based hyper-cross-linked porous organic polymer (CzBMI-POP) was successfully prepared from a new tetra-armed carbazole-maleimide monomer (Bis-Cz(BMI)), which contains biscarbazole units and maleimide side groups.

Comparison of Bicortical Headless Cannulated Screw Fixations, Tension Band Fixations, and Kirschner Wire Fixations of a Jones Fracture: A Biomechanical Study.

Background: The aim of study was to biomechanically compare the fixation of Jones fracture using headless cannulated screw, tension band, and two Kirschner wires.

Methods: A total of 60 fourth-generation, fifth metatarsal synthetic bone models were divided into three groups according to the fixation techniques. A vertical load, oriented from plantar to dorsal and lateral to medial, was applied to the metatarsal specimen that were potted with molding material.

Humic acid attenuates cisplatin-induced nephrotoxicity in rats.

Cisplatin-induced nephrotoxicity, a major limitation of this chemotherapeutic agent, involves oxidative stress, inflammation, and apoptosis. This study investigated the potential renoprotective effects of humic acid in a rat model of cisplatin-induced nephrotoxicity. Forty-two male Wistar rats were assigned to six groups: control, humic acid, cisplatin, cisplatin + humic acid 10 mg/kg, cisplatin + humic acid 20 mg/kg, and cisplatin + humic acid 40 mg/kg.

molecular docking and analysis of atomoxetine.

Although atomoxetine, a selective norepinephrine reuptake inhibitor, is widely used in the treatment of attention-deficit/hyperactivity disorder (ADHD), there is limited data on its cytogenetic effects. This study aimed to investigate the cytotoxicity and genotoxicity of atomoxetine and . Chromosome aberration and micronucleus assays were used to analyze the genotoxic effect of atomoxetine in human peripheral blood lymphocytes under culture conditions.

Relationship between disaster preparedness perception, self-efficacy, and psychological capital among Turkish nurses.

Background: Although disasters continue to increase all over the world and international nursing organizations warn nurses to be ready for disasters, it is stated that the training of nurses for disasters is inadequate in Turkey as in many countries, and studies on this subject are limited AIM: This study aimed to explore the relationship between disaster preparedness perception, self-efficacy, and psychological capital among Turkish nurses.

Methods: This cross-sectional study was conducted with 270 nurses working at a university hospital in Turkey from May 2023 to December 2023.

Results: The mean Disaster Preparedness Perception Scale, General Self-Efficacy Scale, and Psychological Capital Questionnaire scores of the nurses were 73.

Assessment of deep learning technique for fully automated mandibular segmentation.

Introduction: This study aimed to assess the precision of an open-source, clinician-trained, and user-friendly convolutional neural network-based model for automatically segmenting the mandible.

Methods: A total of 55 cone-beam computed tomography scans that met the inclusion criteria were collected and divided into test and training groups. The MONAI (Medical Open Network for Artificial Intelligence) Label active learning tool extension was used to train the automatic model.

Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters.

Background: Gender differences in metabolic response to lifestyle interventions remain poorly explored. This study aimed to evaluate the impact of a six-month Mediterranean diet (MD) intervention combined with regular physical activity on metabolic parameters in overweight adults.

Methods: A prospective cohort study was conducted in an obesity clinic in Rome, Italy, involving overweight adults (BMI ≥ 25 kg/m) motivated to improve their lifestyle.

Nanoparticles for Biomedical Use Derived from Natural Biomolecules: Tannic Acid and Arginine.

: Tannic acid (TA) is a well-known natural phenolic acid composed of ten gallic acids linked to each other with ester bonding possessing excellent antioxidant properties in addition to antimicrobial and anticancer characteristics. Arginine (ARG) is a positively charged amino acid at physiological pH because of nitrogen-rich side chain. : Here, poly(tannic acid-co-arginine) (p(TA-co-ARG)) particles at three mole ratios, TA:ARG = 1:1, 1:2, and 1:3, were prepared via a Mannich condensation reaction between TA and ARG by utilizing formaldehyde as a linking agent.

Evaluation of the effect of dental caries, oral hygiene, and treatment need on oral health-related quality of life among Turkish orphan children and adolescents.

Background: The oral and dental health and related quality of life of orphan children and adolescents-who are considered a vulnerable population-are critical for both individual and public health.

Objectives: This study aimed to investigate the status of the dental caries, oral hygiene, and dental treatment needs among a group of Turkish male orphan children and adolescents, as well as their impact on oral health-related quality of life.

Methods: A total of 112 orphan children and adolescents aged between 9 and 17 years living in a residential care facility in Istanbul, Türkiye, were involved in this cross-sectional study.

Chitosan and Its Nanoparticles: A Multifaceted Approach to Antibacterial Applications.

Chitosan, a multifaceted amino polysaccharide biopolymer derived from chitin, has extensive antibacterial efficacy against diverse pathogenic microorganisms, including both Gram-negative and Gram-positive bacteria, in addition to fungi. Over the course of the last several decades, chitosan nanoparticles (NPs), which are polymeric and bio-based, have garnered a great deal of interest as efficient antibacterial agents. This is mostly due to the fact that they are used in a wide variety of applications, including medical treatments, food, chemicals, and agricultural products.

Behavioral Emotion Regulation Strategies and Symptoms of Psychological Distress Among Turkish University Students.

The purpose of this study was to examine the association between behavioral emotion regulation strategies and symptoms of depression, anxiety, and stress among Turkish university students. Participants consisted of 633 students continuing their university education in two different universities in Türkiye. Participants completed a data collection tool comprising a Sociodemographic Information Form, the Behavioral Emotion Regulation Questionnaire, and the Depression Anxiety Stress Scales-21.

A comparative evaluation of haematological and biochemical parameters of and species living in Gökova Bay, Türkiye.

This study aims to determine and compare the reference values of the haematological and biochemical blood parameters of two fish species collected from the Gökova Bay (Muğla, South-Western of Türkiye): the non-native and invasive Randall's threadfin bream, and the native Common pandora, . Both species inhabit the same environment and compete for resources. Blood samples were collected from a total of 100 fish samples (50 and 50 ) which were caught from a depth of 30 to 60 meters between February 2023 and July 2024.

Healing beyond bone: a qualitative study of the core decompression experience of physically active patients with stage II hip avascular necrosis.

Background: Avascular necrosis (AVN) of the femoral head is a degenerative condition characterized by ischemic bone death, resulting in pain and impaired mobility. Core decompression, a surgical intervention, is widely performed for stage II AVN to alleviate symptoms and delay disease progression. While clinical and radiological outcomes are well-documented, the psychosocial dimensions of recovery remain underexplored.

Bibliometric analysis of neurocysticercosis case reports and evaluation of presented cases.

Neurocysticercosis (NCC) has been classified as a neglected tropical disease by the World Health Organization (WHO), with the condition being regarded as the most significant parasitic disease affecting the nervous system. Hence, the aim of this study was to conduct a review of previously published case reports on this topic in order to ascertain whether there is an increasing trend of NCC worldwide and evaluate the cases that have been presented. After a comprehensive search of the Web of Science Core Collection using the keywords "neurocysticercosis" and "case reports", studies were selected by applying inclusion criteria.

Discrepancies in the number of lines of arrested growth (LAG) in the tissues of the humerus and phalanx of sea turtles.

Information on the age of vertebrate species such as sea turtles is crucial for planning management and conservation actions. The age of sea turtles has been estimated by skeletochronological analysis using skeletal growth marks in different bones. This study focused on the consistency of the number of visible lines of arrested growth (LAG) observed from the humerus and phalanx bone used for age estimation in Chelonia mydas and Caretta caretta.

Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models.

Objectives: Liver fibrosis resulting from nonalcoholic fatty liver disease (NAFLD) and metabolic disorders is highly prevalent in patients with severe obesity and poses a significant health challenge. However, there is a lack of data on the effectiveness of noninvasive factors in predicting liver fibrosis. Therefore, this study aimed to assess the relationship between these factors and liver fibrosis through a machine learning approach.

Antibiotic Resistance Trends in ESKAPE Pathogens Isolated at a Health Practice and Research Hospital: A Five-Year Retrospective Study.

Introduction: Antimicrobial resistance remains a global threat with increasing morbidity and mortality rates. The aim of this study was to identify the antimicrobial resistance trends among ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) isolated from clinical samples at a Health Practice and Research Hospital over five years.

Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases.

Cardiovascular illnesses are multifactorial disorders and represent the primary reasons for death worldwide, according to the World Health Organization. As a signaling molecule, nitric oxide (NO) is extremely permeable across cellular membranes owing to its unique molecular features, like its small molecular size, lipophilicity, and free radical properties. Some of the biological effects of NO are vasodilation, inhibition in the growth of vascular smooth muscle cells, and functional regulation of cardiac cells.

The long-term and post-prandial effects of berry consumption on endothelial dysfunction in adults: a systematic review and meta-analysis of randomised controlled trials.

This systematic review and meta-analysis evaluated the long-term and post-prandial effects of berry consumption on endothelial dysfunction (ED) in adults. To identify relevant randomised controlled trials (RCTs), a systematic search was run and studies that examined the effects of berries consumption on ED markers were included. A total of 45 RCTs were included, focusing on markers such as flow-mediated dilation (FMD), pulse wave velocity (PWV), augmentation index (AIx), reactive hyperaemia index (RHI) and total peripheral resistance (TPR).

Comparison of Piperacillin-tazobactam and Vancomycin (TZP-VAN) with Piperacillin-tazobactam and Teicoplanin (TZP-TEI) for the risk of Acute Kidney Injury (CONCOMITANT): A prospective observational, multinational, multi-centre cohort study.

Objectives: Both vancomycin (VAN) and teicoplanin (TEI) augment the risk of acute kidney injury (AKI) when combined with piperacillin-tazobactam (TZP). We aimed to compare the risk of AKI among patients receiving TZP-VAN versus TZP-TEI.

Methods: This was a prospective, multinational, multicentre cohort study conducted in 12 centres from Turkiye, Italy and Spain between June 1, 2022, and December 31, 2023.

Biosorption of rhodamine B and sunset yellow dyes on cross-linked chitosan-alginate biocomposite beads: Experimental and theoretical studies.

This research explores the biosorption of Rhodamine B (Rd-B) and Sunset Yellow (SY) dyes using cross-linked chitosan-alginate (Ch-A) biocomposite beads, combining experimental investigations with theoretical studies to elucidate the biosorption mechanisms. The biocomposite beads were synthesized through an eco-friendly cross-linking method, and their structural properties were characterized using various characterization techniques. Complementary theoretical studies using Monte Carlo (MC) simulations and molecular dynamics (MD) calculations provided insights into the molecular interactions between the dyes and the biocomposite beads.

Assessing spinel zinc ferrite nanoparticles in aquatic ecosystems: Toxic threat or beneficial detoxifier for aquatic life?

The effectiveness of magnetic nanoparticles in removing pollutants during water treatment is well established, but their introduction into aquatic ecosystems raises significant toxicity concerns. This study investigates the histological and physiological effects of zinc ferrite magnetic nanoparticles (ZnFeOMNPs) on the Mediterranean mussel (Mytilus galloprovincialis) and examines the impact of concurrent exposure to these nanoparticles and the insecticide thiomethoxam (TMX). Mussels were exposed to nominal concentrations of ZnFeOMNPs (1, 10, 100 mg/L) both individually and with TMX.