Potassium chlorido-tris-(hypersil-oxy)aluminate dimer.

The tris-(tri-methyl-silylsiloxide) ligand, also known as hypersiloxide, is an extremely bulky group. In an attempt to make the monomeric Al(OSi(SiMe)), AlCl was combined with 3 equiv. of potassium hypersiloxide.

Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.

A small library of emetine dithiocarbamate ester derivatives were synthesized in 25-86% yield via derivatization of the N2'- position of emetine. Anticancer evaluation of these compounds in androgen receptor positive LNCaP and androgen receptor negative PC3 and DU145 prostate cancer cell lines revealed time dependent and dose-dependent cytotoxicity. With the exception of compound 4c, all the dithiocarbamate ester analogs in this study showed appreciable potency in all the prostate cancer cell lines (regardless of whether it is androgen receptor positive or negative) with a cytotoxicity IC50 value ranging from 1.

Bond dissocation and conformational energetics of tetrasulfur: a quantum Monte Carlo study.

Variational Monte Carlo (VMC) and fixed-node diffusion Monte Carlo (DMC) calculations are performed for S4. The effect of single- and multireference trial functions, as well as choice of orbitals, is investigated for its effect on the quality of the Monte Carlo estimates. Estimates of symmetric (two S2 molecules) and asymmetric (S atom and S3 molecule) bond dissociation are reported.