The Effect of Obesity and Pregnancy Weight Gain on Maternal and Child Health.

In this study, we estimate the effect of prepregnancy obesity and excessive pregnancy weight gain on infant and maternal health outcomes. We rely on a large sample of maternally linked restricted data from 2004 to 2019 South Carolina birth certificates, which allow us to track the same mothers during multiple pregnancies over a period of more than 15 years. To address possible limitations of previous research, we account for genetic confounders and unobservable maternal and environmental factors by relying on a maternal fixed effects strategy.

Inverted region in the reaction of the quinone reduction in the A-site of photosystem I from cyanobacteria.

Photosystem I from the menB strain of Synechocystis sp. PCC 6803 containing foreign quinones in the A sites was used for studying the primary steps of electron transfer by pump-probe femtosecond laser spectroscopy. The free energy gap (- ΔG) of electron transfer between the reduced primary acceptor A and the quinones bound in the A site varied from 0.

The impact of minimum wage on parental time allocation to children: evidence from the American Time Use Survey.

In this study, using data from the 2003-2019 American Time Use Survey (ATUS), we investigate whether changes in the minimum wage have impacted time allocation to children among low-educated mothers and fathers. Relying on geographic and temporal variation in minimum wage changes across US states, we investigate the impacts of minimum wage increases on total time spent at home with children, time spent on primary childcare, and time spent on enriching childcare activities. Our results indicate that an increase in the minimum wage has a large positive effect on the time low-educated mothers spend on primary childcare and enriching time, with no effect among low-educated fathers.

The efficiency of COVID cases to COVID policies: a robust conditional approach.

This paper examines the efficiency of four major COVID-19 social distancing policies: (i) shelter-in-place orders (SIPO), (ii) non-essential business closures, (iii) mandatory quarantine for travelers, and (iv) bans on large gatherings. Results suggest that the average US state is highly inefficient in producing the fraction of the population that does not have COVID-19 without social distancing policies put in place. We find that having any of the four major social distancing policies increases conditional efficiency by 9.

β-Endorphin and sex differentially modulate the response to EtOH in a site-specific manner.

The effects of alcohol are multifaceted, involving brain circuits regulating reward, motivation, and stress, frequently via the endogenous opioid, beta-endorphin (β-E). It is currently unknown how alcohol affects neural circuit activation in females and how β-E affects ethanol's ability to induce neuronal activation. Therefore, we investigated the impact of acute alcohol treatment on neuronal activation in reward- and stress-related brain circuitry in a sex- and β-E dependent manner.

Fitting an experimental potential energy curve for the 10(0)[4Π] electronic state of NaCs.

We present experimentally determined potential energy curves for the 10(0)[4Π] electronic state of NaCs. The 10(0)[4Π] state exhibits a double-minimum structure, resulting in a distinctive bound-free fluorescence signature. The perturbation facilitated optical-optical double resonance method was used to obtain Doppler-free excitation spectra corresponding to rovibrational transitions to the 10(0)[4Π] state.

Augmentation of C17.2 Neural Stem Cell Differentiation via Uptake of Low Concentrations of ssDNA-Wrapped Single-Walled Carbon Nanotubes.

Nanostructured biomaterials are extensively explored in clinical imaging and in gene/drug delivery applications. However, limited studies are performed that examine the influence that nanomaterials may have on cell behavior over long time scales at nonlethal concentrations. This study is designed to investigate whether carbon nanotubes are able to augment cell behavior at low concentrations.

The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy.

Our previous studies have shown that the HECT E3 ubiquitin ligase NEDD4 interacts with LC3 and is required for starvation and rapamycin-induced activation of autophagy. Here, we report that NEDD4 directly binds to SQSTM1 via its HECT domain and polyubiquitylates SQSTM1. This ubiquitylation is through K63 conjugation and is not involved in proteasomal degradation.

β-endorphin regulates alcohol consumption induced by exercise restriction in female mice.

Animal models have long been used to study the mechanisms underlying the complex association between alcohol and stress. Female mice prevented from running on a home-cage activity wheel increase voluntary ethanol consumption. β-endorphin is an endogenous opioid involved in negatively regulating the stress response and has also been implicated in the risk for excessive drinking.

The impact of free trial acceptance on demand for alternative nicotine products: evidence from experimental auctions.

Objectives: This study explored the relationship between product trials and consumer demand for alternative nicotine products (ANP).

Methods: An experimental auction was conducted with 258 adult smokers, wherein participants were randomly assigned to one of four experimental conditions. The participants received the opportunity to try, but did not have to accept, one of three relatively novel ST products (i.

Social-emotional aspects of male escorting: experiences of men working for an agency.

Social situations and emotional correlates associated with male sex work have not been well documented. Most of the research in this area focuses on sexual activity with little mention of other aspects of the job. Yet, research with female sex workers finds significant social and emotional components to sex work.