2 results match your criteria: "50603 University of Malaya[Affiliation]"
Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase.
J Cancer
September 2017
Department of Pharmacology, Faculty of Medicine, 50603 University of Malaya, Kuala Lumpur, Malaysia.
Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely melanoma, myeloma and lymphoma overexpressed DHODH protein and treatment with A771726 and Brequinar sodium resulted in cell cycle arrest at S-phase.
View Article and Find Full Text PDFSedation scoring and managing abilities of intensive care nurses post educational intervention.
Nurs Crit Care
May 2017
Department of Nursing Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Background: Inappropriate sedation assessment can jeopardize patient comfort and safety. Therefore, nurses' abilities in assessing and managing sedation are vital for effective care of mechanically ventilated patients.
Aims And Objectives: This study assessed nurses' sedation scoring and management abilities as primary outcomes following educational interventions.