A Protamine Knockdown Mimics the Function of in .

() is an autosomal meiotic drive system found worldwide in natural populations of This gene complex induces the preferential and nearly exclusive transmission of the chromosome in / males. This selfish propagation occurs through the interplay of the locus, its enhancers and the locus during spermatid development. The key distorter locus, , encodes a truncated but enzymatically active RanGAP (RanGTPase-activating protein), a key nuclear transport factor in the Ran signaling pathway.