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Article Synopsis
  • Excessive HMGB1 protein release from heart cells after ischemia worsens inflammation and heart damage upon reperfusion.
  • Electroacupuncture targeting specific acupoints in mice reduces HMGB1 levels and inflammation after heart injury, indicating a protective effect.
  • This protective mechanism likely relies on the vagal nerve and specific nicotinic receptors, as shown by experiments involving nerve cutting and receptor antagonists.
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