MYSM1-AR complex-mediated repression of Akt/c-Raf/GSK-3β signaling impedes castration-resistant prostate cancer growth.

Epigenetic alterations that lead to dysregulated gene expression in the progression of castration-resistant prostate cancer (CRPC) remain elusive. Here, we investigated the role of histone deubiquitinase MYSM1 in the pathogenesis of prostate cancer (PCa). Tissues and public datasets of PCa were evaluated for MYSM1 levels.

Increased Respiratory Modulation of Blood Pressure in Hypertensive Patients.

Objective: Although the important role of respiratory modulation of the cardiovascular system in the development of hypertension has been demonstrated in animal studies, little research has assessed this modulation in essential hypertensive patients. We aimed to explore whether respiratory-related variations in cardiovascular variables are changed in hypertensive patients and their potential relationships with the respiratory pattern.

Methods: Respiration, ECG, and beat-to-beat blood pressure (BP) were simultaneously measured in 46 participants (24 hypertensive patients and 22 normotensive participants) during rest and a mental arithmetic task (MAT).

pH low insertion peptide mediated cell division cycle-associated protein 1 -siRNA transportation for prostatic cancer therapy targeted to the tumor microenvironment.

Prostate cancer (PCa) is a common malignancy in male urinary system. Cell division cycle-associated protein 1 (CDCA1) is expressed highly in many cancer cells. Yet, whether CDCA1 play an important role in PCa progression is uncertain.

Impaired cardiorespiratory coupling in young normotensives with a family history of hypertension.

Objectives: Although recent animal studies have highlighted the importance of cardiorespiratory coupling in the pathogenesis of hypertension, little research has assessed the cardiorespiratory coupling in humans at high risk of developing hypertension. The aim of this study was to investigate the cardiorespiratory coupling in healthy young individuals genetically predisposed to hypertension at both rest and mental stress conditions.

Methods: We studied 39 normotensive male participants [21 with (FH+) and 18 without (FH-) a family history of hypertension].

The relationships among host transcriptional responses reveal distinct signatures underlying viral infection-disease associations.

Genome-scale DNA microarrays and computational biology facilitate new understanding of viral infections at the system level. Recent years have witnessed a major shift from microorganism-centric toward host-oriented characterization and categorization of viral infections and infection related diseases. We established host transcriptional response (HTR) relationships among 23 different types of human viral pathogens based on calculating HTR similarities using computational integration of 587 public available gene expression profiles.

EHFPI: a database and analysis resource of essential host factors for pathogenic infection.

High-throughput screening and computational technology has greatly changed the face of microbiology in better understanding pathogen-host interactions. Genome-wide RNA interference (RNAi) screens have given rise to a new class of host genes designated as Essential Host Factors (EHFs), whose knockdown effects significantly influence pathogenic infections. Therefore, we present the first release of a manually-curated bioinformatics database and analysis resource EHFPI (Essential Host Factors for Pathogenic Infection, http://biotech.

Morphological study of Schwann cells remyelination in contused spinal cord of rats.

Objective: To study the role and effect of Schwann cells (SCs) remyelination in contused spinal cord.

Methods: Green fluorescence protein expressing-SCs were transplanted into the epicenter, rostral and caudal tissues of the injury site at 1 week after the spinal cords were contused. At 6 weeks, the spinal cords were removed for cryosections, semithin sections and ultrathin sections, and then immunocytochemical staining of myelin basic protein (MBP), P0 protein (P0) and S100 protein (S100) was carried out on the cryosections.