Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories.

Spatial periodicity in grid cell firing has been interpreted as a neural metric for space providing animals with a coordinate system in navigating physical and mental spaces. However, the specific computational problem being solved by grid cells has remained elusive. Here, we provide mathematical proof that spatial periodicity in grid cell firing is the only possible solution to a neural sequence code of 2-D trajectories and that the hexagonal firing pattern of grid cells is the most parsimonious solution to such a sequence code.

Major transitions: how college students interpret the process of changing fields of study.

Unlabelled: Selecting a major is one of the most consequential decisions a student will make in college. Though major selection is often conceived of as a discrete choice made at a particular point in time, many students change their majors at least once during college. This article examines the process of changing majors as a key education transition.

Harmonizing spatial scales and ecological theories to predict avian richness and functional diversity within forest ecosystems.

Classic ecological theory has proven that temperature, precipitation and productivity organize ecosystems at broad scales and are generalized drivers of biodiversity within different biomes. At local scales, the strength of these predictors is not consistent across different biomes. To better translate these theories to localized scales, it is essential to determine the links between drivers of biodiversity.

Urinary arsenic and spontaneous pregnancy loss - a hypothesis-generating case-control investigation in western Romania.

Arsenic occurs as a natural contaminant of drinking water supplies in arsenic endemic areas, posing a threat to public health. Our aim was to evaluate the relationship between urinary arsenic concentrations and spontaneous pregnancy loss in a population with low-moderate level drinking water arsenic exposure (mostly <10 μg/L). We enrolled 150 women with incident spontaneous pregnancy losses and 150 controls with ongoing pregnancies matched by gestational age.

Racial/ethnic differences in medication for addiction treatment for opioid use disorders among pregnant women in treatment facilities supported by state funds.

Introduction: Medication for addiction treatment (MAT) for opioid use disorder (OUD) in pregnant women is known to improve neonatal health outcomes. Despite the benefits of this evidence-based treatment for OUD, MAT has been underutilized during pregnancy among certain racial/ethnic groups of women in the United States. The purpose of this study was to examine racial/ethnic differences and factors that affect MAT administration among pregnant women with OUD seeking treatment at publicly funded facilities.

Treatment outcomes among pregnant women with cannabis use disorder.

Cannabis use disorder (CUD) among pregnant women is on the rise in the United States. The American College of Obstetricians and Gynecologists have recommended against the use of cannabis during pregnancy and breastfeeding. However, limited research exists on CUD treatment in this vulnerable population.

Factors Associated with Professional Mental Help-Seeking Among U.S. Immigrants: A Systematic Review.

Structural and cultural barriers have led to limited access to and use of mental health services among immigrants in the United States (U.S.).

Impact of endocrine disruptors from mother's diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool.

Diet has long been known to modify physiology during development and adulthood. However, due to a growing number of manufactured contaminants and additives over the last few decades, diet has increasingly become a source of exposure to chemicals that has been associated with adverse health risks. Sources of food contaminants include the environment, crops treated with agrochemicals, inappropriate storage (e.

Uncertainty in vulnerability of networks under attack.

This study builds conceptual explanations and empirical examinations of the vulnerability response of networks under attack. Two quantities of "vulnerability" and "uncertainty in vulnerability" are defined by scrutinizing the performance loss trajectory of networks experiencing attacks. Both vulnerability and uncertainty in vulnerability quantities are a function of the network topology and size.

Glyphosate exposure and preterm birth: A nested case-control pilot study.

Preterm birth (PTB) is associated with a high risk of infant mortality and long-term adverse health effects. Glyphosate is a broad-spectrum herbicide applied in agricultural and non-agricultural settings. Studies suggested an association between maternal exposure to glyphosate and PTB among mostly racially homogenous populations, though results were inconsistent.

Supply-side predictors of fatal drug overdose in the Washington/Baltimore HIDTA region: 2016-2020.

Background: Rising rates of fentanyl- and polydrug-involved drug overdose deaths have prompted inquiry into the role of drug supply in fatal overdose outcomes in the United States. To date, however, there have been few empirical investigations of drug enforcement strategies on fatal overdose rates, despite knowledge that both drug use and supply are often geographically distributed. To address this limitation, we examined measures of drug enforcement as predictors of next-year fatal overdose rates in the Washington/Baltimore High Intensity Drug Trafficking Area (W/B HIDTA).

Environmental toxicants and placental function.

The placenta is a temporary endocrine organ that facilitates gas, nutrient, and waste exchange between maternal and fetal compartments, partially shielding the fetus from potentially hazardous environmental toxicants. However, rather than being "opaque", the placenta is translucent or even transparent to some potential fetal developmental hazards, including toxic trace elements (TEs), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and environmental phenols (EPs) to which women with pregnancy are frequently exposed. These agents are both passively and actively transferred to the fetal compartment, where endocrine disruption, oxidative stress, and epigenetic changes may occur.

Challenges and opportunities for mining adverse drug reactions: perspectives from pharma, regulatory agencies, healthcare providers and consumers.

Monitoring drug safety is a central concern throughout the drug life cycle. Information about toxicity and adverse events is generated at every stage of this life cycle, and stakeholders have a strong interest in applying text mining and artificial intelligence (AI) methods to manage the ever-increasing volume of this information. Recognizing the importance of these applications and the role of challenge evaluations to drive progress in text mining, the organizers of BioCreative VII (Critical Assessment of Information Extraction in Biology) convened a panel of experts to explore 'Challenges in Mining Drug Adverse Reactions'.

Value-based payment, the safety net, and rethinking risk.

Safety-net providers can benefit from demonstrations of condition-specific and defined-scope-of-practice alternative payment models that account for the nonfinancial as well as financial risks that providers face.

Global dataset of species-specific inland recreational fisheries harvest for consumption.

Inland recreational fisheries, found in lakes, rivers, and other landlocked waters, are important to livelihoods, nutrition, leisure, and other societal ecosystem services worldwide. Although recreationally-caught fish are frequently harvested and consumed by fishers, their contribution to food and nutrition has not been adequately quantified due to lack of data, poor monitoring, and under-reporting, especially in developing countries. Beyond limited global harvest estimates, few have explored species-specific harvest patterns, although this variability has implications for fisheries management and food security.

State-of-the-Art Statistical Approaches for Estimating Flood Events.

Reliable quantile estimates of annual peak flow discharges (APFDs) are needed for the design and operation of major hydraulic infrastructures and for more general flood risk management and planning. In the present study, linear higher order-moments (LH-moments) and nonparametric kernel functions were applied to APFDs at 18 stream gauge stations in Punjab, Pakistan. The main purpose of this study was to evaluate the impacts of different quantile estimation methods towards water resources management and engineering applications by means of comparing the state-of-the-art approaches and their quantile estimates calculated from LH-moments and nonparametric kernel functions.

Comparing the prediction performance of item response theory and machine learning methods on item responses for educational assessments.

To obtain more accurate and robust feedback information from the students' assessment outcomes and to communicate it to students and optimize teaching and learning strategies, educational researchers and practitioners must critically reflect on whether the existing methods of data analytics are capable of retrieving the information provided in the database. This study compared and contrasted the prediction performance of an item response theory method, particularly the use of an explanatory item response model (EIRM), and six supervised machine learning (ML) methods for predicting students' item responses in educational assessments, considering student- and item-related background information. Each of seven prediction methods was evaluated through cross-validation approaches under three prediction scenarios: (a) unrealized responses of new students to existing items, (b) unrealized responses of existing students to new items, and (c) missing responses of existing students to existing items.

Patients' and Nurses' Perceptions of Diabetes Self-Management in Oman: A Qualitative Study.

Patient-centered care enhances diabetes self-management; however, the primary care nurse's role in promoting diabetes self-management within a patient-centered care model is unexplored. This study investigated the perceptions of Omani patients with type-2 diabetes and their clinic nurses on the nurses' role in promoting diabetes self-management within a patient-centered care approach. The thematic analysis of the data from individual interviews with patients (n = 24) revealed two themes: patients experienced "missteps on an unclear path" and "nurses doing their best.

Large scale similarity search across digital reconstructions of neural morphology.

Most functions of the nervous system depend on neuronal and glial morphology. Continuous advances in microscopic imaging and tracing software have provided an increasingly abundant availability of 3D reconstructions of arborizing dendrites, axons, and processes, allowing their detailed study. However, efficient, large-scale methods to rank neural morphologies by similarity to an archetype are still lacking.

Differentiating Black and Hispanic: outcome differences of segregated communities and police shootings in the USA, 2015-2020.

Background: Police shootings are unevenly spatially distributed, with substantive spikes throughout the USA. While minorities are disproportionately the victims of police force, social or structural factors associated with this distribution are not well understood. The objective of this work was to evaluate police shootings in relation to victim race or ethnicity and residential segregation and racial diversity.

Spatial context target relearning following a target relocation event: Not mission impossible.

Our visual system relies on memory to store and retrieve goal-relevant structures and information from the environment for the purpose of optimizing the allocation of attention. This concept, referred to as contextual cueing, has been demonstrated using visual search tasks, wherein repeated visual contexts lead to reduced search times compared with random displays. Subsequently, when an unexpected change occurs in the environment, or memory fails, a cognitive expense is incurred as the mind tries to resolve the conflict with the memory of the previous environmental context.

Factors Related to Concussion Knowledge, Attitudes, and Reporting Behaviors in US High School Athletes: A Systematic Review.

Background: Sport-related concussions are a major public health problem with only 50% of concussed teens reporting their symptoms. The purpose of this systematic review was to identify individual and institutional factors that contribute to concussion knowledge, attitude, and reporting behaviors among US high school athletes.

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol was used to direct the process of this systematic review.

Marijuana use in Pregnant Women with Disabilities in the United States.

Objectives: While perinatal marijuana use is increasing, limited research exists related to its use during pregnancy among vulnerable subpopulations of women with disabilities. The purpose of this study is to assess marijuana use in pregnant U.S.

The effect of wear on slip-resistance of winter footwear with composite outsoles: A pilot study.

Falls on icy surfaces are among the top causes of injuries for workers exposed to the outdoor environment. Our recent field study showed that a new generation of winter footwear incorporating composite outsoles was able to reduce slips and falls on icy surfaces by 68% and 78%, respectively. The widespread adoption of this type of footwear may lead to substantial reductions in pain, suffering and costs of fall-related injuries.

Projecting the effects of land subsidence and sea level rise on storm surge flooding in Coastal North Carolina.

Much of the United States Atlantic coastline continues to undergo subsidence due to post glacial settlement and ground water depletion. Combined with eustatic sea level rise (SLR), this contributes to an increased rate of relative SLR. In this work, we utilize the ADvanced CIRCulation model to project storm surges across coastal North Carolina.