165 results match your criteria: "4400 University Dr.[Affiliation]"

This study analyzed 1432 questions asked in 19 surveys ( = 43,014) on COVID-19 vaccines between January 2020 and August 2022 using dimensions including (1) information sources about COVID-19 vaccine, (2) information about the access, effectiveness, and side effects of COVID-19 vaccine, (3) COVID-19 vaccine hesitancy (i.e. false perception, skepticism, and vaccine refusal), (4) motivations to get the COVID-19 vaccine (i.

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An OpenStreetMap derived building classification dataset for the United States.

Sci Data

November 2024

Geography and Geoinformation Science, College of Science, George Mason University, 4400 University Dr., Fairfax, 22030, VA, USA.

Building classification is crucial for population estimation, traffic planning, urban planning, and emergency response applications. Although essential, such data is often not readily available. To alleviate this problem, this work presents a comprehensive dataset by providing residential/non-residential building classification covering the entire United States.

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During large geomagnetic storms, red auroras are typically observed from low-latitude countries such as Japan. The color arises from a specific emission line of oxygen atoms at high altitudes. However, during the May 10-11th 2024 superstorm, magenta auroras were observed above Japan instead of the typical red.

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Where did they come from, where did they go? Niche conservatism in woody and herbaceous plants and implications for plant-based paleoclimatic reconstructions.

Am J Bot

November 2024

Department of Earth and Environmental Sciences and Museum of Paleontology, University of Michigan, North University Building, 1100 North University Ave., Ann Arbor, 48109-1005, MI, USA.

Premise: The ecological conditions that constrain plants to an environmental niche are assumed to be constant through time. While the fossil record has been used previously to test for niche conservatism of woody flowering plants, additional studies are needed in other plant groups especially since they can provide insight with paleoclimatic reconstructions, high biodiversity in modern terrestrial ecosystems, and significant contributions to agriculture.

Methods: We tested climatic niche conservatism across time by characterizing the climatic niches of living herbaceous ginger plants (Zingiberaceae) and woody dawn redwood (Metasequoia) against paleoniches reconstructed based on fossil distribution data and paleoclimatic models.

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Objective: This study sought to determine consensus opinions from subspecialty radiologists and imaging physicists on the relative importance of image quality features in CT.

Methods: A prospective survey of subspecialty radiologists and medical physicists was conducted to collect consensus opinions on the relative importance of ten image quality features: axial sharpness, blooming, contrast, longitudinal sharpness, low contrast axial sharpness, metal artifact, motion, noise magnitude, noise texture, and streaking. The survey was first sent to subspecialty radiologists in volunteer leadership roles in the American College of Radiology and Radiological Society of North America, thereafter relying on snowball sampling.

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It was previously shown that DNA breathing, thermodynamic stability, as well as transcriptional activity and transcription factor (TF) bindings are functionally correlated. To ascertain the precise relationship between TF binding and DNA breathing, we developed the multi-modal deep learning model EPBDxDNABERT-2, which is based on the Extended Peyrard-Bishop-Dauxois (EPBD) nonlinear DNA dynamics model. To train our EPBDxDNABERT-2, we used chromatin immunoprecipitation sequencing (ChIP-Seq) data comprising 690 ChIP-seq experimental results encompassing 161 distinct TFs and 91 human cell types.

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Salt marshes act as natural barriers that reduce wave energy during storm events and help protect coastal communities located in low-lying areas. This ecosystem can be an important asset for climate adaptation due to its particular capability of vertically accrete to adjust to long-term changes in water levels. Therefore, understanding marsh protection benefits thresholds in the face of sea-level rise (SLR) is important for planning future climate adaptation.

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Unequal Health Burden from Air Pollution among Minors in Education.

Environ Sci Technol

August 2024

Gangarosa Department of Environmental Health Rollins School of Public Health, Emory University, 201 Dowman Dr, Atlanta, Georgia 30322, United States.

Air pollution exposure has been linked to a variety of adverse health outcomes among minors; yet little is known about the associated health inequity across regions and schools. Here, we assessed the unequal health burden linked to particulate matter exposure among minors of 10,358 schools in China through 12,439,232 individual health records. Our findings highlight the persistent health risks with superlinear concentration-response patterns and following inverted U-shaped risk trends, that each 10 μg/m increase in PM exposure resulted in 4.

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Background: Most implementation science resources (e.g., taxonomies) are published in English.

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Patterns of habitat use directly influence a species' fitness, yet for many species an individual's age can influence patterns of habitat use. However, in tropical rainforests, which host the greatest terrestrial species diversity, little is known about how age classes of different species use different adjacent habitats of varying quality. We use long-term mist net data from the Amazon rainforest to assess patterns of habitat use among adult, adolescent (teenage) and young understory birds in forest fragments, primary and secondary forest at the Biological Dynamics of Forest Fragments Project in Brazil.

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Background: There is a lack of data on the impact of donor liver function tests (LFTs) on pancreas transplantation outcomes. Understanding their contribution could expand the donor pool.

Methods: Using the UNOS database, data from January 2010-2022 was retrospectively analyzed.

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Communication research establishes that when confronted with information contradicting their beliefs, people tend to 'backlash' by doubling down on their prior. Can international popular culture be the context of backlash? This paper analyzes two K-pop Subreddits ( and ) populated by non-fans. A particular focus is given to their attitudinal changes upon being exposed to news stories about South Korea.

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Clinicians and patients seeking electronic health applications face challenges in selecting effective solutions due to a high market failure rate. Conversational agent applications ("chatbots") show promise in increasing healthcare user engagement by creating bonds between the applications and users. It is unclear if chatbots improve patient adherence or if past trends to include chatbots in electronic health applications were due to technology hype dynamics and competitive pressure to innovate.

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Previous studies have shown that inorganic arsenic (iAs) exposure may be associated with genotoxic and cytotoxic effects. The aim of this study was to evaluate the relationship between several polymorphisms in and genes and urinary As and the relationship between these polymorphisms and pregnancy loss. We determined urinary As concentrations and performed genotyping analysis in 50 cases of spontaneous pregnancy loss and 50 controls, matched to cases on gestational age.

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The early to middle Permian Dohol Formation is characterized by a significant presence of shale deposits. While these shales exhibit a low potential to generate hydrocarbons, there is a need to ascertain the possible reasons for the low hydrocarbon generation potential. Also, there are several unidentified properties and attributes associated with these shales in terms of their inorganic geochemical characteristics and their mineralogy.

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The red wolf () is a critically endangered canid that exists solely because of the establishment of the population in the late 1980s. Yet, the population under human care suffers from gastrointestinal (GI) disease in captivity. While the cause of GI disease is unknown, it is speculated that environmental factors can influence GI health of zoo-managed red wolves.

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Understanding the impact of genomic variants on transcription factor binding and gene regulation remains a key area of research, with implications for unraveling the complex mechanisms underlying various functional effects. Our study delves into the role of DNA's biophysical properties, including thermodynamic stability, shape, and flexibility in transcription factor (TF) binding. We developed a multi-modal deep learning model integrating these properties with DNA sequence data.

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Exogenous Klotho Extends Survival in COVID-19 Model Mice.

Pathogens

November 2023

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA.

A striking feature of COVID-19 disease is the broad spectrum of risk factors associated with case severity, as well as the diversity of clinical manifestations. While no central agent has been able to explain the pathogenesis of SARS-CoV-2 infection, the factors that most robustly correlate with severity are risk factors linked to aging. Low serum levels of Klotho, an anti-aging protein, strongly correlate with the pathogenesis of the same risk factors and manifestations of conditions similar to those expressed in severe COVID-19 cases.

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The effect of tread patterns on slip resistance of footwear outsoles based on composite materials in icy conditions.

J Safety Res

December 2023

Department of Mechanical Engineering, George Mason University, 4400 University Dr, Fairfax, VA 22030, USA; KITE Research Institute, Toronto Rehabilitation Institute - University Health Network, 550 University Ave, Toronto M5G2A2, Canada. Electronic address: https://volgenau.gmu.edu/profile/view/579736.

Introduction: Falls on icy surfaces are the leading cause of injuries for outdoor workers. Footwear outsole material and geometrical design parameters are the most significant factors affecting slips-and-falls. Recently, composite materials have been incorporated into outsoles to improve traction, yet the best design parameters are not fully understood.

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Explaining conflict violence in terms of conflict actor dynamics.

Sci Rep

December 2023

Department of Computational and Data Sciences, George Mason University, 4400 University Dr, Fairfax, VA, 22030, USA.

We study the severity of conflict-related violence in Colombia at an unprecedented granular scale in space and across time. Splitting the data into different geographical regions and different historically-relevant periods, we uncover variations in the patterns of conflict severity which we then explain in terms of local conflict actors' different collective behaviors and/or conditions using a simple mathematical model of conflict actors' grouping dynamics (coalescence and fragmentation). Specifically, variations in the approximate scaling values of the distributions of event lethalities can be explained by the changing strength ratio of the local conflict actors for distinct conflict eras and organizational regions.

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Sea level rise (SLR) is the most significant climate change-related threat to coastal wetlands, driving major transformations in coastal regions through marsh migration. Landscape transformations due to marsh migration are manifested in terms of horizontal and vertical changes in land cover and elevation, respectively. These processes will have an impact on saltmarsh wave attenuation that is yet to be explored.

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Metagenomic Analysis of a Continuous-Flow Aerobic Granulation System for Wastewater Treatment.

Microorganisms

September 2023

Department of Chemistry and Biochemistry, George Mason University, 4400 University Dr, Fairfax, VA 22030, USA.

Aerobic granulation is an emerging process in wastewater treatment that has the potential to accelerate sedimentation of the microbial biomass during secondary treatment. Aerobic granulation has been difficult to achieve in the continuous flow reactors (CFRs) used in modern wastewater treatment plants. Recent research has demonstrated that the alternation of nutrient-abundant (feast) and nutrient-limiting (famine) conditions is able to promote aerobic granulation in a CFR.

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Examining DNA Breathing with pyDNA-EPBD.

bioRxiv

September 2023

Theoretical Division, Los Alamos National Laboratory, Los Alamos, 87544, NM, 87102.

Motivation: The two strands of the DNA double helix locally and spontaneously separate and recombine in living cells due to the inherent thermal DNA motion.This dynamics results in transient openings in the double helix and is referred to as "DNA breathing" or "DNA bubbles." The propensity to form local transient openings is important in a wide range of biological processes, such as transcription, replication, and transcription factors binding.

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Background: Breast cancer (BC) is among the most common forms of cancer experienced by women. Up to 80% of BC survivors treated with chemotherapy experience chemotherapy-induced neuropathy (CIN), which degrades motor control, sensory function, and quality of life. CIN symptoms include numbness, tingling, and/or burning sensations in the extremities; deficits in neuromotor control; and increased fall risk.

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Spatial periodicity in grid cell firing has been interpreted as a neural metric for space providing animals with a coordinate system in navigating physical and mental spaces. However, the specific computational problem being solved by grid cells has remained elusive. Here, we provide mathematical proof that spatial periodicity in grid cell firing is the only possible solution to a neural sequence code of 2-D trajectories and that the hexagonal firing pattern of grid cells is the most parsimonious solution to such a sequence code.

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