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Wood Smoke Extract Promotes Extracellular Matrix Remodeling in Normal Human Lung Fibroblasts.
Int J Toxicol
December 2021
Cell Biology Laboratory, Department of Research in Pulmonary Fibrosis, 42635National Institute of Respiratory Diseases Ismael Cosío Villegas (INER), Mexico City, Mexico.
Wood smoke (WS) contains many harmful compounds, including polycyclic aromatic hydrocarbons (PAHs). WS induces inflammation in the airways and lungs and can lead to the development of various acute and chronic respiratory diseases. Pulmonary fibroblasts are the main cells involved in the remodeling of the extracellular matrix (ECM) during the WS-induced inflammatory response.
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