The role of pure diffuse mesangial hypercellularity in patients with proteinuria.

Background: Pure diffuse mesangial hypercellularity (DMH), in its primary form, is a relatively rare histological finding, and scant data exist in the literature regarding its clinical course and prognosis in nephrotic adults with this diagnosis.

Methods: We retrospectively analyzed the clinical and histological data of 8 out of 41 patients with the above diagnosis in regard to response to the treatment, outcome and prognostic indicators.

Results: Six patients received oral prednisolone as initial therapy, five of whom receiving it as monotherapy at first.