15 results match your criteria: "400 University Drive[Affiliation]"

There is an urgent need to develop safer and more effective modalities for the treatment of numerous pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Over the past decades, cyclodextrins (CDs) have gathered great attention as potential drug carriers due to their ability to enhance their bioactivities and properties. Likewise, selenium (Se) and tellurium (Te) have been extensively studied during the last decades due to their possible therapeutical applications.

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Selenization of Small Molecule Drugs: A New Player on the Board.

J Med Chem

May 2024

Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, United States.

There is an urgent need to develop safer and more effective modalities for the treatment of a wide range of pathologies due to the increasing rates of drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout the years, selenium (Se) has attracted a great deal of attention due to its important role in human health. Besides, a growing body of work has unveiled that the inclusion of Se motifs into a great number of molecules is a promising strategy for obtaining novel therapeutic agents.

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Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro.

Int J Mol Sci

April 2024

Department of Pharmaceutical Sciences, School of Pharmacy, Loma Linda University, Shryock Hall 24745 Stewart Street, Loma Linda, CA 92350, USA.

Acute myeloid leukemia (AML) is a hematological malignancy that is characterized by an expansion of immature myeloid precursors. Despite therapeutic advances, the prognosis of AML patients remains poor and there is a need for the evaluation of promising therapeutic candidates to treat the disease. The objective of this study was to evaluate the efficacy of duocarmycin Stable A (DSA) in AML cells in vitro.

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Secreted protein acidic and rich in cysteine (SPARC), a conserved secreted glycoprotein, plays crucial roles in regulating various biological processes. SPARC is highly expressed and has profound implications in several cancer types, including melanoma. Understanding the mechanisms that govern SPARC expression in cancers has the potential to lead to improved cancer diagnosis, prognosis, treatment strategies, and patient outcomes.

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Purpose: Cancer and its treatments accelerate biological aging. This analysis tested the hypothesis that exercise and diet reduce oxidative stress and prevent telomere shortening in breast cancer survivors.

Methods: In a 2 × 2 factorial design, 342 breast cancer survivors who were insufficiently physically active and had overweight or obesity at enrollment were randomized to one of four treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet.

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Background: Research has shown medication for opioid use disorder (MOUD) to have positive effects, including reducing HIV and HCV transmission, but important barriers to access remain among people who inject drugs (PWID). Barriers include lack of social and familial support, bureaucracy, distance to treatment, poverty, and homelessness. However, we know little about how these barriers interact with each other to shape PWID's drug treatment access and retention.

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Purpose: Obesity increases the risk of cancer recurrence and death in survivors of breast cancer. This study tested the hypothesis that exercise alone, diet alone, and the combination of exercise plus diet reduce body weight and improve body composition in survivors of breast cancer.

Methods: In this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to one of four treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet.

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Practice changing standardization of lower extremity lymphedema quantitative measurements with integrated patient reported outcomes will likely refine and redefine the optimal risk-reduction strategies to diminish the devastating limb-related dysfunction and morbidity associated with treatment of gynecologic cancers. The National Cancer Institute (NCI), Division of Cancer Prevention brought together a diverse group of cancer treatment, therapy and patient reported outcomes experts to discuss the current state-of-the-science in lymphedema evaluation with the potential goal of incorporating new strategies for optimal evaluation of lymphedema in future developing gynecologic clinical trials.

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Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer.

Anal Chem

July 2020

Department of Mechanical Engineering, The Pennsylvania State University, 137 Reber Building, University Park, Pennsylvania 16802, United States.

Bladder cancer is an increasingly common malignancy, and muscle invasive bladder cancer is associated with particularly high rates of morbidity and mortality. The morphologic and molecular diversity of bladder cancer poses significant challenges in elucidating the invasion mechanisms responsible for disease progression. Furthermore, conventional invasion assays do not provide a physiological context for studying bladder cancer invasion within 3D microenvironments and have limited ability to capture the contribution of cellular phenotypic heterogeneity to disease progression.

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Measuring and validating concentrations of steroid hormones in the skin of bottlenose dolphins ().

Conserv Physiol

May 2020

National Marine Mammal Foundation, 2240 Shelter Island Drive Suite 200, San Diego, CA 92106, USA.

A previously published analytical method demonstrated the quantification of the hormone cortisol in cetacean skin. However, little is known about the transfer of hormones between blood and skin. Recognizing that such information is essential to effectively using skin samples within marine mammal stress research, the primary goals of this study were to (i) expand on the number of steroid hormones proved quantifiable in the cetacean skin matrix and (ii) validate the use of cetacean skin as a matrix for measuring stress-related hormones.

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Biodiversity is suffering dramatic declines across the globe, threatening the ability of ecosystems to provide the services on which humanity depends. Mainstreaming biodiversity into the plans, strategies and policies of different economic sectors is key to reversing these declines. The importance of this mainstreaming is recognized by the Convention on Biological Diversity (CBD) and its Aichi targets.

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The L-type calcium channel blocker fendiline has been shown to interfere with Ras-dependent signaling in K-Ras mutant cancer cells. Earlier studies from our lab had shown that treatment of pancreatic cancer cells with fendiline causes significant cytotoxicity and interferes with proliferation, survival, migration, invasion and anchorage independent growth. Currently there are no effective therapies to manage PDACs.

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Secondary healing of fingertip amputations: a review.

Hand (N Y)

September 2014

Division of Plastic and Reconstructive Surgery, Saint John Regional Hospital, 400 University Drive, Saint John, New Brunswick E2L 4L2 Canada.

Most literature on fingertips reviews new surgical techniques of coverage while many surgeons prefer the results of secondary healing. This article reviews the current best evidence and concepts about secondary healing in fingertip injuries.

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Background: Although posttransplant diabetes mellitus (PTDM) is associated with poor long-term outcomes short-term outcomes are not well studied in renal transplant recipients (RTRs).

Methods: RTRs between January 1999 and December 2000 (n = 181) stratified according to the occurrence of diabetes mellitus (DM), namely, non-DM (n = 72), previous DM (n = 88), and PTDM (n = 21) were compared for infections, hospital readmissions, and graft rejections during the first 6 months posttransplantation.

Results: PTDM showed patients affected by a significantly higher rate of infections (57.

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A morphological comparison of narrow, low-gradient streams traversing wetland environments to alluvial streams.

Environ Manage

December 2002

Department of Geography & Geology, University of Wisconsin-Fond du Lac, 400 University Drive, Fond du Lac, WI 54935, USA.

Twelve morphological features from research on alluvial streams are compared in four narrow, low-gradient wetland streams located in different geographic regions (Connecticut, Indiana, and Wisconsin, USA). All four reaches differed in morphological characteristics in five of the features compared (consistent bend width, bend cross-sectional shape, riffle width compared to pool width, greatest width directly downstream of riffles, and thalweg location), while three reaches differed in two comparisons (mean radius of curvature to width ratio and axial wavelength to width ratio). The remaining five features compared had at least one reach where different characteristics existed.

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