Perspective on CFD studies of coronary artery disease lesions and hemodynamics: a review.

Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to quantify the severity of CAD and the associated invasive and noninvasive imaging technologies in order to quantify the anatomical parameters of diameter stenosis, area stenosis, and hemodynamic indices of coronary flow reserve and fractional flow reserve.

Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach.

Intraventricular flow is important in understanding left ventricular function; however, relevant numerical simulations are limited, especially when heart valve function is taken into account. In this study, intraventricular flow in a patient-specific left ventricle has been modelled in two-dimension (2D) with both mitral and aortic valves integrated. The arbitrary Lagrangian-Eulerian (ALE) approach was employed to handle the large mesh deformation induced by the beating ventricular wall and moving leaflets.

When the storm passes unnoticed--a case series of thyroid storm.

Introduction: Thyroid crisis is an acute manifestation of thyrotoxicosis. Approximately 1-2% of patients progress to a thyroid storm, often precipitated by a physiologically stressful event. If unrecognized or left untreated, thyroid storm may result in cardiovascular collapse and death.

Percutaneous interventional strategies in the treatment of chronic total coronary occlusions.

Chronic total coronary occlusions which make up 10% to 20% of all interventional procedures in high-volume centres remain a vexing problem for invasive cardiologists for 2 main reasons. First, they are only successfully recanalised in about 60% of attempts with most failures resulting from an inability to cross the lesions. Laser guidewire appears to be a promising innovation in overcoming this obstacle.

Percutaneous Inoue-Balloon Mitral Commissurotomy in Patients with Coexisting Moderate Mitral Regurgitation, and Severe Subvalvular Disease and/or Mitral Calcification.

The present study examined the safety and immediate and late outcome of 12 patients with coexisting moderate (angiographic grade 2+) mitral regurgitation and significant subvalvular disease and/or calcified mitral valves (group 1) after percutaneous balloon mitral commissurotomy (BMC) and compared the results with 64 patients without these adverse valve features (group 2). BMC produced a significantly smaller echocardiographically determined mitral valve area improvement in group 1 compared with group 2 (from 0.7 +/- 0.