5 results match your criteria: "3Centre National de la Recherche Scientifique[Affiliation]"

Short genome report of cellulose-producing commensal 1094.

Stand Genomic Sci

May 2018

1Département de Microbiologie, Unité de Génétique des Biofilms, Institut Pasteur, 25-28 rue du Dr. Roux, F-75015 Paris, France.

Article Synopsis
  • Bacterial surface colonization and biofilm formation depend on an extracellular polymeric matrix, often made up of cellulose, which helps cells stick to each other and surfaces.
  • Researchers sequenced the complete genome of a cellulose-producing strain called 1094 and compared it to five related strains in phylogenetic group A.
  • The study includes an analysis of genes responsible for cellulose biosynthesis and explores reasons why some strains may have lost this crucial ability.
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Globin's structure and function in vesicomyid bivalves from the Gulf of Guinea cold seeps as an adaptation to life in reduced sediments.

Physiol Biochem Zool

August 2015

IFREMER, Laboratoire Environnement Profond, Unité de Recherche Etude des Ecosystèmes Profonds, F-29280 Plouzané, France; 2Sorbonne Universités, Université Pierre et Marie Curie Université Paris 06, Unité Mixte de Recherche (UMR) 7144, Équipe Adaptation et Biologie des Invertébrés en Conditions Extrêmes, Station Biologique, F-29680 Roscoff, France; 3Centre National de la Recherche Scientifique (CNRS), UMR 7144, Adaptation et Diversité en Milieu Marin, Station Biologique, F-29680 Roscoff, France; 4Laboratoire de Spectrométrie de Masse des Interactions et des Systèmes, UMR 7140, CNRS-Université Louis Pasteur Chimie de la Matière Complexe, F-67008 Strasbourg, France.

Vesicomyid bivalves form dense clam beds in both deep-sea cold seeps and hydrothermal vents. The species diversity within this family raises questions about niche separation and specific adaptations. To compare their abilities to withstand hypoxia, we have studied the structure and function of erythrocyte hemoglobin (Hb) and foot myoglobin (Mb) from two vesicomyid species, Christineconcha regab and Laubiericoncha chuni, collected from the Regab pockmark in the Gulf of Guinea at a depth of 3,000 m.

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Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases.

Inflamm Bowel Dis

October 2013

1Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, Marseille, France; 2Institut National de la Santé et de la Recherche Médicale (Inserm), U1104, Marseille, France; 3Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France; 4Inserm, UMR_S1090, TAGC, Marseille, France; 5Aix-Marseille University, Marseille, France; 6Oncogenetic Laboratory, Institut Paoli Calmettes, Marseille, France; 7Université Lille Nord de France, Lille, France; 8Inserm U995, Lille, France; 9CHU Lille, Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Claude, Huriez, Lille, France; 10UDSL, Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France; 11Icahn School of Medicine at Mount Sinai, Mount Sinai, New York; 12Inserm U1080, IRCAN Team 3, Nice, France; 13Université de Nice Sophia Antipolis, Nice, France; and 14Human Tissue Biobank Centre de Ressources Biologiques INSERM, Pasteur Hospital, Nice, France.

Background: Vanin-1 is an epithelial pantetheinase, which regulates intestinal inflammation in mouse. We investigated whether human VNN1 levels could be associated to the susceptibility to inflammatory bowel diseases (IBD) and explored the participation of PPARg to these processes.

Methods: We studied VNN1 expression in colon biopsies from IBD patients.

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Serum erythropoietin level less than 100U/L and a transfusion requirement of less than 2 units per month are the best predictive factors for response to treatment by erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes. To investigate the factors influencing the response to erythropoiesis-stimulating agents, we enrolled 127 low/int-1 myelodysplastic syndrome patients at diagnosis in a biological study of erythropoiesis. The 54 non-responders had a significantly lower number of burst-forming unit-erythroid and colony-forming unit-erythroid than responders.

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