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FANCD2 genome binding is nonrandom and is enriched at large transcriptionally active neural genes prone to copy number variation.
Funct Integr Genomics
October 2024
Department of Cell and Molecular Biology, University of Rhode Island, 379 Center for Biotechnology and Life Sciences, 120 Flagg Road, Kingston, RI, USA.
Article Synopsis
- Fanconi anemia (FA) is a rare genetic disorder linked to congenital issues and an increased risk of cancer and bone marrow failure, with neurological problems becoming more prominent, known as Fanconi Anemia Neurological Syndrome (FANS).
- The study aims to clarify the role of the FANCD2 protein and the FA pathway using advanced genomics techniques.
- Findings reveal that FANCD2 selectively binds to important areas of the genome, particularly at gene start sites and large neural genes related to brain development, potentially explaining its role in maintaining the stability of these genes amid replication stress.