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The effect of voluntary wheel running on 129/SvEvTac and C3H/Ibg alcohol consumption.
Alcohol
June 2019
University of Colorado, Institute for Behavioral Genetics, 1480 30th Street, 447 University of Colorado at Boulder, Boulder, CO, 80309-0447, United States; Department of Integrative Physiology, 354 University of Colorado at Boulder, Boulder, CO, 80309-0354, United States. Electronic address:
The mesolimbic dopaminergic reward pathway is activated by both alcohol and exercise, suggesting exercise as a possible treatment or preventative method for alcohol-use disorders (AUDs). Prior studies conducted in our lab have demonstrated the hedonic substitution of voluntary alcohol consumption for voluntary wheel running in female C57Bl/6Ibg mice, and a trend in male C57Bl/6Ibg mice. Given the important contribution of genetic background on AUDs, this study aims to assess the effects of voluntary wheel running on voluntary alcohol consumption in two moderate alcohol-consuming strains of mice, C3H/Ibg and 129/SvEvTac.
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