[Structural and functional interrelations of immunocompetent cells in the mammary gland of lactating rats and in the small intestine of newborn rats during suckling period].

The interrelation of quantitative changes of immunocompetent cells (ICC) in the mammary gland of lactating rats and in the small intestine of neonatal rats in their suckling period was studied. The dynamics of the ratio of ICC in the mammary gland of females and in the small intestine of the offspring in the early postnatal period was examined. Maximal numbers of ICC in the mammary gland was detected on day 3 of lactation, the subsequent reduction of their number was accompanied by an increase of the number if intestinal ICC in the offspring, which further progressed with a transition of pups to mixed nutrition.

[Rat reproductive cells as biological indicators of the effect of environmental factors].

The effect of one-month-long inhalation exposure of male rats to sulphureous anhydrate, phenol, ammonia or to the mixture of these substances with formaldehyde and lead acetate, on the parameters of spermatogenesis was studied. The exposure of animals to sulphureous anhydrate or to the mixture indicated above resulted in the asynchronization of spermatogenic cycle, which was more significant than that caused by the separate application of substances studied. This mixture induced a 20% reduction in the number of tubules, containing spermatogonia, and a 20-30% increase in the number of tubules, containing spermatozoa.

[Morphological peculiarities of rat liver reaction to chronic xenobiotic exposure].

The data of the morphological studies of liver of animals subjected to chronic (3 months long) intoxication with different chemical substances (ammonium nitrogen, nitrite nitrogen, fluorine, chromium, arsenic) are presented. The xenobiotics tested induced stereotyped responses in liver which differed in their intensity and the extent of hemomicrocirculatory and inflammatory-destructive alterations. Most pronounced reactive changes were found in animals exposed to arsenic compounds, while sodium nitrate caused practically no destructive changes in hepatocytes.

[Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators].

Structural changes of thymus in heliotrin hepatitis were characterized by distinct dynamics which on the whole suggested the progressing hypoplasia of its cortex. Immunostimulants parandin and thymalin suppressed the extent of thymocyte destruction and stimulated their mitotic activity. Although these parameters did not reach the control levels, the significant deceleration of hypoplastic processes in thymus, particularly in its cortex, were detected.

[The effect of perftoran on the morphofunctional status of the digestive system organs in experimental duodenal ulcer].

The authors studied the effect of perftoran (PF) on the morpho-functional parameters of alimentary system organs (ASO) (liver, pancreas, stomach, duodenum, and small intestine) in rats with experimental chronic acetate duodenal ulcer. Inflammatory-infiltrative and dystrophic changes were found in the ASO tissues which led to activation of the enzymes superoxide dismutase and catalase in their homogenates. PF pharmacotherapy reduces the inflammatory-infiltrative changes in the ASO tissues and normalizes the enzyme systems of antioxidant protection.

[The effect of phenazepam on the pancreatic excretory function in thermal stress].

The excretory function of the pancreas was studied on albino rats during thermal stress and ACTH (corticotropine) administration. Stress inhibited the enzyme-synthesizing and enzyme-secreting functions of the gland. The tranquilizer phenazepam influencing the GABA-ergic brain systems exerted a protective effect on pancreatic exosecretion in stress and its strength depended on the administration regimen of the drug.

Two cases of unilateral verrucous nevus.

We report two patients with epidermal nevus: one with linear verrucous nevus and one with inflammatory linear verrucous epidermal nevus. The patients first showed manifestations of nevus at different ages (soon after birth and at the age of seven), and the findings progressed differently. In both cases, warty plaques were located unilaterally, strictly following Blaschko's lines.