Evaluation of insulin resistance and sodium sensitivity in normotensive offspring of hypertensive individuals.

Background: Sodium sensitivity (SS) and insulin resistance (IR) might be a common link in the pathogenesis of essential hypertension. The aim of the present study is to investigate the relationship, if any, between SS and IR in a population with a family predisposition to develop hypertension.

Methods: Twenty normotensive subjects aged 20 to 40 years with a family history of hypertension (1 or both parents hypertensive) and no other risk factor (group A) and 10 normotensive subjects aged 20 to 40 years without a family history of hypertension (group B) were enrolled.

Variability of peritoneal protein loss in diabetic and nondiabetic patients on continuous ambulatory peritoneal dialysis.

In order to evaluate the influence of diabetes mellitus on peritoneal membrane permeability, we studied the peritoneal protein loss in two groups of patients. Group A consisted of 16 patients (9 nondiabetics and 7 diabetics) who were in the first month of treatment on continuous ambulatory peritoneal dialysis (CAPD). Group B consisted of 13 patients (7 nondiabetics and 6 diabetics) who had been on CAPD for approximately 15 months.