Study of the effect of superoxide dismutase on acute renal failure in dogs.

Warm ischaemia was provoked by occlusion of the left renal artery in dogs narcotized with Nembutal and it was studied whether a small (0.5 mg/kg body weight /n = 6/) or a large dose (5 mg/kg body weight /n = 7/) of superoxide dismutase (SOD) improves renal function during 90 min reperfusion, compared to the control group (n = 6). In the first period after release of occlusion (min 0-15) the GFR and cPAH values reached 10-20% of those in the contra lateral kidney with normal circulation.