[EFFECT OF PROPRANOLOL ON CYTOKINE PROFILE IN AN EXPERIMENTAL MODEL OF HUMAN T LYMPHOCYTES (JURKAT CELLS) IN VITRO].

In this research, in order to establish the role of neuroendocrine mechanisms in the processes of immunomodulation, the effect of propranolol on the cytokine profile in an experimental model of human T lymphocytes (Jurkat cells) in vitro was investigated. Jurkat cells were incubated under standard conditions. Stimulation of the Jurkat cells was performed by incubation with Phytohemagglutinin (PHA) (50 μg/ml) in the presence of propanonol (10-4 M) and without it at 370 for 24 hours.

PECULIARITIES OF EVALUATION OF THE ORAL FLUID ANTIOXIDANT ACTIVITY IN PATIENTS WITH LOCAL OR SYSTEMIC DISEASES.

The aim - in the given research, the difficulties in interpreting the study results of oxidative homeostasis of oral fluid are analyzed. Changes in the total antioxidant activity of blood and saliva can be multidirectional - an increase or decrease in the oral fluid indicator and a reduction in the parameter of blood plasma can be recorded. To resolve the emerging difficulties, there was proposed a parallel assessment of the dynamics of changes in the total antioxidant activity of blood plasma and oral fluid in the patients of 4 groups with nosological forms of fundamentally different in the distribution and localization of the pathological process, which include: phlegmons of the maxillofacial region, partial absence of teeth, type 2 diabetes mellitus and the pelvic inflammatory diseases.

TOPICAL ISSUES OF COPD MANAGEMENT IN GEORGIA.

Chronic obstructive pulmonary disease (COPD) is the major cause of chronic morbidity and mortality throughout the world. USAID Health Care Improvement Project (HCI) had collaborated with the Ministry of Labor, Healthcare and Social Affairs of Georgia in 2012-2014 to improve quality of care for high-burden and under-diagnosed diseases, including asthma and COPD. The Aim of the study was to evaluate the effectiveness (quality, consistency and continuity) of medical care in COPD patients in one of the regions of Georgia after 5 years from the ending of the project.

RELATIONSHIP BETWEEN ORAL SQUAMOUS CELL CARCINOMA AND IMPLANTS (REVIEW).

In this review, we have discussed the relationships between oral squamous cell carcinoma (OSCC) and dental implants. In the last decade, dental implants have been widely used for the treatment of complete or partial edentulism. Despite the fact that they have seen incredible success and the use of dental implants increases, concerns over safety and efficiency is rising as well.

NEUROLOGICAL DISORDERS AMONG THE USERS OF HOMEMADE ARTISANAL EPHEDRONE PSYCHOSTIMULANTS AND INVESTIGATION OF THIOGAMMA EFFICACY IN THEIR TREATMENT.

60 patients of the Narcological Clinic "Neogene" were enrolled into the study. The following participation criteria were used: a diagnosis of mental and behavioral disorders associated with ephedrone use; withdrawal state. Toxic encephalopathy; age - 20-65 years; gender - male.

[THE ROLE AND PLACE OF VIRTUAL CT COLONOSCOPY IN COMPLEX RADIOLOGICAL DIAGNOSIS OF COLON DISEASES].

Nowadays CT colonoscopy is one of the basic methods for colon disease diagnostic. In Georgia mentioned method is used rarely despite of its high diagnostic potential. The current research aims to populate CT colonoscopy to be widely used in diagnostic as well as preventive healthcare, develop radiological semiotics of colon specifications and pathology changes.

[NEUROPROTECTIVE EFFECT OF AMINOGUANIDINE IN EXPERIMENTAL OBSTETRIC ANTIPHOSPHOLIPID SYNDROME].

The aim of the research was to investigate the effect of aminoguanidine on the content of autoantibodies in the serum, nitric oxide synthesis (NO), glial fibrillary acidic protein (GFAP) content and indicators of free radical oxidation in the cerebral hemispheres of BALB/c mice with antiphospholipid syndrome (APS) on the 18th day of pregnancy. An increase in the content of autoantibodies to brain proteins (120 kDa, 150 kDa, and >170 kDa) was detected in the serum of BALB/c mice with APS on the 18th day of pregnancy. An increase in the content of GFAP (total), GFAP (49-37 kDa), NO2¯, NO3¯ and prooxidant-antioxidant system imbalance in the cerebral hemispheres of pregnant mice with APS was established.

[ABERRATION GENOMS HAVING PEOPLE'S REHABILITATION IN SOME ASPECTS OF MUSCULAR AND VEGETATIVE SYSTEM].

Rehabilitation ifluences of adaptive physical exercises are based on interrelation of impellent and also vegetative and muscular functions. In particular at corrective picked up physical exercises according to functionalities of an organism muscular and vegetative system causes positive changes in work of internal bodies. The purpose of our experiment was to study the role of physical exertion in the process of comparative restoration of impaired homeostasis of individuals with limited abilities (Down syndrome), along with drug therapies; establishing the form and power of physical impact.

[PRODUCTION OF REACTIVE OXYGEN SPECIES AND DEVELOPMENT OF APOPTOSIS IN BLOOD LEUKOCYTES IN EXPERIMENTAL ANTIPHOSPHOLIPID SYNDROME].

The aim of the study is to investigate the processes of apoptosis and the level of formation of reactive oxygen species (ROS) in blood cells of BALB/c female mice in experimental antiphospholipid syndrome (APS). The content of living, apoptotic and necrotic cells in blood leukocytes was evaluated. Apoptosis in cells was detected using Annexin V conjugated to GFP and propidium iodide.

[ANALYSIS OF THE USE OF ANTIBIOTIC THERAPY IN PREMATURE INFANTS, TAKING INTO ACCOUNT THE CHARACTERISTICS OF THE NEONATAL PERIOD].

This article presents the results of sensitivity/resistance of microbial strains isolated from three biotopes, in premature infants: mucous membranes of the respiratory tract, urinary system and colon after 72 hours after birth, as well as on the 14th and 30th day of life. During the study, total 677 strains of various microorganism species were isolated of which gram-positive flora - 386 microbial strains, almost 1.5 times predominated over gram-negative (291 strains) flora.

CORRELATION BETWEEN CONNECTIVE TISSUE METABOLISM AND THYROID DYSFUNCTION IN RATS WITH PERIODONTITIS.

The aim of the study was to clarify mechanisms of the periodontitis development in rats with thyroid dysfunction based on a comparative analysis of the correlations between the connective tissue metabolism indices and the concentration of thyroid stimulating hormone, free thyroxine and free triiodothyronine in blood serum. 12-14-week-old inbred white male rats (n=48) were included to the experiment. They were randomly divided into the following groups: control; animals with a model of periodontitis; animals with periodontitis in a setting of hyperthyroidism; animals with periodontitis in a setting of hypothyroidism.

COMPARISON OF EARLY POST-OPERATIVE PERIOD OF ENDO-ACAB WITH OFF-PUMP CABG: RETROSPECTIVE STUDY CONDUCTED AT TBILISI HEART AND VASCULAR CLINIC.

Our aim was to compare early post-operative period of Endo-ACAB with OPCABG. We retrospectively studied 760 cases of all patients who had underwent urgent or planned coronary artery bypass grafting at the "Tbilisi Heart and Vascular Clinic" from November 2015 till November 2017. Patients were divided into two group: first group patients who had underwent Endo-ACAB and second group patients who had underwent OPCABG.

CLINICAL-DIAGNOSTIC PECULIARITIES OF WITHDRAWAL SYNDROME CAUSED BY CONSUMPTION OF HOME-MADE DRUG SYNTHESIZED FROM EPHEDRA PLANT "VINT".

According to the above-mentioned, the study aiming at description of clinico-diasgnostical peculiarities of withdrawal states caused by consumption of Ephedra plant home-made drug - "Vint" has been conducted. 50 patients 20-65 of age, hospitalized with ephedrone withdrawal effect (withdrawal effect caused by consumption of the drug prepared from Ephedra plant or classic "Vint"), were involved in the study conducted at Narcological Clinic "Neogeni". The patients were divided into two main groups: in the first group were united the patients with the withdrawal effect caused by consumption of the drug prepared from Ephedra plant and in the second group -"classical pharmaceutical "Vint" consumers.

INCIDENCE OF TEENAGE PREGNANCY IN GEORGIA AND AUSTRALIA. PATTERNS OF SOCIAL ACCEPTANCE AND RELATED HEALTHCARE CONCERNS.

Teenage pregnancy has been a target for prevention in many countries. Teen motherhood may adversely influence social determinants of health, including education attainment, employment and reliance on welfare support. We compared socioeconomic factors and geographical influencers affecting teenage pregnancy and birth outcomes across Georgia and Australia.

CORTICAL INTRAMEDULLARY FIBULAR GRAFT IN SURGICAL TREATMENT OF LONG BONES NONUNION.

Aim of the study is clinical evaluation of usage of cortical intramedular autografts, while treatment of long bones non-unions. During 2003-2013 years, in Traumatology Orthopedical Clinic "Syntese" and L.T.

PHARMACEUTICAL ACTIVATORS OF ATP-DEPENDENT POTASSIUM CHANNELS AS POTENTIAL NEPHROPROTECTORS AGAINST GLOMERULAR AND TUBULAR DAMAGE TO THE NEPHRON (REVIEW).

Considering the incidence, high risk of progression and severe consequences of renal pathology, a preventive therapy as well as correction of kidney dysfunction are issues of a great importance today. An essential condition for an improvement of nephroprotection is a determination of new mechanisms of disturbances and restoration of homeostatic kidney processes. A unique physiological role of ATP-dependent potassium (KATP) channels and their participation in adaptive-compensatory reactions substantiate the feasibility of search for effective nephroprotectors among pharmacological modulators of their activity.

[THE MICROBIAL STRUCTURE OF THE MUCOUS MEMBRANE OF THE RESPIRATORY TRACT IN PREMATURE INFANTS].

This article presents the results of a microbiological study of microbial contamination of the respiratory tract mucosa of 124 premature newborns with different gestational age (24-28 and 29-36 weeks) who are in the critical medicine department of LTD "Imedis Clinica", Tbilisi. For the study, modern methods of qualitative and quantitative microbiological analysis were used, as well as the determination of the sensitivity/resistance of the isolated microorganisms to antibiotics using standard disks by the discdiffusion method and the serial dilution method on solid nutrient media, which were performed on newborns for the first 72 hours, on days 14 and 30. In the first 72 hours microbial colonization was established only in 20.

EXPANDED PHENOTYPE OF TMEM67 GENE MUTATION (CASE REPORT).

Human ciliopathies are a class of multi-organ genetic disorders caused by defects of proteins expressed at the primary cilium, an organelle present on the cell surface of almost all cell types. Thus far, dozens of causative genes for ciliopathies have been identified and many of them are known to cause allelic disease. Of particular interest is the TMEM67 gene, encoding the transmembrane protein meckelin.

MODULATION OF ANTITUMOR IMMUNE RESPONSE IN MOUSE PROSTATE CANCER MODEL.

Aim of study - prostate cancer is second most common cancer in men worldwide, and fifth leading cause of death from cancer in men (6.6% of the total men deaths). Unfortunately, once cancer spreads outside of prostate, it becomes incurable.

[CLINICAL AND EPIDEMIOLOGICAL PECULIARITIES OF CYSTIC ECHINOCOCCOSIS IN CHILDREN].

The postoperative period of cystic echinococcosis was studied in 13 children. Demographic, epidemiological, clinical diagnosis, treatment, number location, and development of cysts and serologic data were analyzed. Age of children at diagnosis range 5 to 17 years.

Prevalence of self-reported food allergy in different age groups of georgian population.

Epidemiological studies in high income countries suggested that a big proportion of the population in Europe and America report adverse reactions to food. Self-reported prevalence of food allergy varied from 1.2% to 17% for milk, 0.

Early repolarization, localization of J point elevation on ECG and arrhythmias.

Final aim of this observational study was to determine correlation between localization of J point elevation and number of premature ventricular beats. The 52 patients (19-68 years old; 31 men and 21 women) were divided in two groups based on localization of J point elevation. First Group - 9 patients (5 men and 4 women) with J-point elevation ≥1 mm in ≥2 contiguous inferior and/or lateral leads on a standard 12-lead ECG reading, Second Group - other 43 (26 men and 17 women) patients with another localization of J point elevation.

Mycoplasma Pneumoniae and Chlamydophila pneumoniae in hospitalized children with bronchiolitis.

Bronchiolitis is an acute lower respiratory tract infection in early childhood caused mainly by different viruses. Etiology of bronchiolitis have been studied in different environments and populations. Respiratory syncytial virus (RSV), human Metapneumovirus (hMPV), human Bocavirus (hBoV), human Rhinoviruses (hRV) have consistently been shown to predominate.

Fuzzy approaches in pediatrics.

In this paper we present a review of applications of fuzzy methods in children and adolescence health care. Based on the several examples, available from journal papers, conference proceedings and book chapters we have concentrate ourselves on problems in the pediatrics that have been or can be solved with the help of fuzzy methodology. The paper is organised as follows.