804 results match your criteria: "29238 France; Universite de Brest[Affiliation]"

Rare Earth Elements (REE) and several trace elements abundances in mussel's shells collected along the St. Lawrence River, the Estuary, and the Gulf of St. Lawrence (EGSL) reveal coherent chemical variations, with a sharp contrast between freshwater and seawater bivalves.

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Fetoscopy laser photocoagulation is a widely adopted procedure for treating Twin-to-Twin Transfusion Syndrome (TTTS). The procedure involves photocoagulation pathological anastomoses to restore a physiological blood exchange among twins. The procedure is particularly challenging, from the surgeon's side, due to the limited field of view, poor manoeuvrability of the fetoscope, poor visibility due to amniotic fluid turbidity, and variability in illumination.

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Introduction: External radiotherapy is a major treatment for localized prostate cancer (PCa). Dose escalation to the whole prostate gland increases biochemical relapse-free survival but also acute and late toxicities. Dose escalation to the dominant index lesion (DIL) only is of growing interest.

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Heart failure is a chronic condition that affects millions of people worldwide and is associated with high morbidity and mortality. Remote monitoring, which includes the use of non-invasive connected devices, cardiac implantable electronic devices and haemodynamic monitoring systems, has the potential to improve outcomes for patients with heart failure. Despite the conceptual and clinical advantages, there are still limitations in the widespread use of these technologies.

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Energy consumption in MRI: Determinants and management options.

J Neuroradiol

March 2024

Service d'Imagerie Médicale, CHU Brest, Univ. Brest, Boulevard Tanguy Prigent, Brest CEDEX, 29609, France; INSERM UMR 1101, Laboratoire de Traitement de L'Information Médicale - LaTIM, Université de Bretagne Occidentale, 22, Avenue C. Desmoulins, Brest 29238 Cedex 3, France.

Background: Energy consumption awareness is a known concern, and radiology departments have energy-intensive consuming machines. The means of energy consumption management in MRI scanners have yet to be evaluated.

Purpose: To measure the MRI energy consumption and to evaluate the means to reduce it.

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The novel dinuclear complex related to the [FeFe]-hydrogenases active site, [Fe(μ-pdt)(κ-dmpe)(CO)] (), is highly reactive toward chlorinated compounds CHCl ( = 1, 2) affording selectively terminal or bridging chloro diiron isomers through a C-Cl bond activation. DFT calculations suggest a cooperative mechanism involving a formal concerted regioselective chloronium transfer depending on the unrotated or rotated conformation of two isomers of .

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Article Synopsis
  • Four new metallophosphonates were synthesized using a hydrothermal method from thianthrene-2-ylphosphonic acid, resulting in unique structures characterized by a lamellar configuration of inorganic and organic networks.
  • The compounds display significant thermal stability and were analyzed for their thermal properties using thermogravimetric analysis, confirming the presence of water molecules in their formulae.
  • Magnetic studies revealed dominant antiferromagnetic interactions in the materials at varying temperatures, with further insights provided by first-principles simulations, and the optical properties showed distinct absorption and emission behaviors influenced by the organic component and transition metals.
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Platelet-rich plasma (PRP) is a rising therapy treating locomotor system lesions such as knee osteoarthritis. The objective of this study was to evaluate patients' satisfaction 6 to 12 months after a PRP injection for cartilage lesions of their knee under real-life conditions. Patients' satisfaction was assessed by a specific questionnaire named SATMED-Q©, which explores six different dimensions of a given treatment.

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Background: The French region of Brittany presents one of the highest cystic fibrosis (CF)-causing allele frequency in Europe. Here, we tested two hypotheses: i) CF-causing allele carriers arrived by sea in the middle of the 1st millennium AD, and ii) a selective advantage for healthy carriers explains this high rate.

Methods: From the census of cystic fibrosis patients, frequency maps of the most widespread alleles were established.

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Multistep synthesis of a novel copper complex with potential for Alzheimer's disease diagnosis.

J Biol Inorg Chem

December 2023

Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe NBD, 1 rue de Chablis, 93000, Bobigny, France.

Positron emission tomography (PET) imaging of Aβ plaques, is recognized as a tool for the diagnosis of Alzheimer's disease. As a contribution to the development of new strategies for early diagnosis of the disease, using PET medical imaging technique, a new copper complex, the [Cu(TE1PA-ONO)] was synthesized in ten steps. The key step of our strategy is the coupling of a monopicolinate-N-alkylated cyclam-based ligand with a moiety capable of recognizing Aβ plaques via a successful and challenging Buchwald-Hartwig coupling reaction.

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Sound externalization in dynamic binaural listening: A comparative behavioral and EEG study.

Hear Res

December 2023

University of Brest, CNRS Lab-STICC UMR 6285, 6 avenue Victor Le Gorgeu, CS 93837, 29238 Brest Cedex 3, France.

Binaural reproduction aims at recreating a realistic sound scene at the ears of the listener using headphones. Unfortunately, externalization for frontal and rear sources is often poor (virtual sources are perceived inside the head, instead of outside the head). Nevertheless, previous studies have shown that large head-tracked movements could substantially improve externalization and that this improvement persisted once the subject had stopped moving his/her head.

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A 12-Year Experimental Design to Test the Recovery of Butterfly Biodiversity in an Urban Ecosystem: Lessons from the Parc Urbain des Papillons.

Insects

September 2023

Laboratoire Population Environnement Développement, Faculté des Sciences, Campus Saint-Charles, Aix Marseille University, IRD, 3 Place Victor-Hugo, CEDEX 3, 13331 Marseille, France.

Urbanization is one of the main threats to biodiversity. However, some urban green spaces could act as refuges for urban fauna if the composition of the flora were less horticultural and if a less intensive management strategy is adopted. Among the taxa, butterflies are experiencing a strong decline from European to regional scales.

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Electromechanical interactions between cell membrane and nuclear envelope: Beyond the standard Schwan's model of biological cells.

Bioelectrochemistry

February 2024

Univ Brest, CNRS, Lab-STICC, CS 93837, 6 avenue Le Gorgeu, 29238 Brest Cedex 3, France. Electronic address:

We investigate little-appreciated features of the hierarchical core-shell (CS) models of the electrical, mechanical, and electromechanical interactions between the cell membrane (CM) and nuclear envelope (NE). We first consider a simple model of an individual cell based on a coupled resistor-capacitor (Schwan model (SM)) network and show that the CM, when exposed to ac electric fields, acts as a low pass filter while the NE acts as a wide and asymmetric bandpass filter. We provide a simplified calculation for characteristic time associated with the capacitive charging of the NE and parameterize its range of behavior.

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The fifteenth edition of the international workshop organized by the "Tumour Targeting and Radiotherapies network" of the Cancéropôle Grand-Ouest focused on the latest advances in internal and external radiotherapy from different disciplinary angles: chemistry, biology, physics, and medicine. The workshop covered several deliberately diverse topics: the role of artificial intelligence, new tools for imaging and external radiotherapy, theranostic aspects, molecules and contrast agents, vectors for innovative combined therapies, and the use of alpha particles in therapy.

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Mandibular retrognathia (C2Rm) is one of the most common oral pathologies. Acquiring a better understanding of the points of impact of C2Rm on the entire skull is of major interest in the diagnosis, treatment, and management of this dysmorphism, but also permits us to contribute to the debate on the changes undergone by the shape of the skull during human evolution. However, conventional methods have some limits in meeting these challenges, insofar as they require defining in advance the structures to be studied, and identifying them using landmarks.

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Multi-site, Multi-domain Airway Tree Modeling.

Med Image Anal

December 2023

Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, 200240, China; Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, 200240, China; Department of Automation, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

Article Synopsis
  • Open international challenges are now the main way to evaluate algorithms for computer vision and image analysis, especially in pulmonary airway segmentation.
  • A new challenge, ATM'22, was organized to provide a large-scale dataset of 500 annotated CT scans to help improve algorithm performance in this area.
  • The results showed that deep learning models that enhanced topological continuity performed best, and the challenge offers an open-call design for accessing data and evaluations.
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Synthesis of ether lipids: natural compounds and analogues.

Beilstein J Org Chem

September 2023

Univ. Brest, CNRS, CEMCA UMR 6521, 6 Avenue Victor Le Gorgeu, 29238 Brest, France.

Ether lipids are compounds present in many living organisms including humans that feature an ether bond linkage at the -1 position of the glycerol. This class of lipids features singular structural roles and biological functions. Alkyl ether lipids and alkenyl ether lipids (also identified as plasmalogens) correspond to the two sub-classes of naturally occurring ether lipids.

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Pneumocystis jirovecii is a transmissible fungus responsible for severe pneumonia (Pneumocystis pneumonia [PCP]) in immunocompromised patients. Missense mutations due to atovaquone selective pressure have been identified on cytochrome b (CYB) gene of P. jirovecii.

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[Phalloplasty by radial forearm free flap in the context of female-to-male gender reassignment surgery].

Ann Chir Plast Esthet

November 2023

Service de chirurgie plastique, reconstructrice et esthétique, centre hospitalier universitaire de Brest, boulevard Tanguy-Prigent, 29200 Brest, France; Faculté de médecine, université de Brest, 22, rue Camille-Desmouqlins, 29238 Brest, France.

Aims: The aims of this article are to provide an overview of the technique of phalloplasty by radial forearm free flap in the context of female-to-male gender reassignment surgery, with a specific focus on surgical technical details and the prevention of postoperative complications.

Methods: In the light of our 30 years of experience in caring for female-to-male transgender individuals and conducting a critical review of the literature, we exhaustively present our technique of radial forearm free flap phalloplasty in female-to-male gender reassignment surgery.

Results: The technique of radial forearm free flap phalloplasty, utilizing a one-stage approach for neourethral and neophallus construction based on the "tube within a tube" principle, not only achieves an aesthetically pleasing appearance of the neophallus resembling a normal penis with tactile and erogenous sensitivities but also yields a functional neourethra and satisfactory penile rigidity using implants for standing voiding and sexual intercourse.

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Model predictive control (MPC) is an outstanding control method which can achieve superior dynamic response, nonlinear control and multi-objective collaborative control. However, because of unfixed switching frequency, the harmonic spectrum of the output current is dispersed, which would make it difficult to design the output filter. In this work, a double voltage vector model predictive control (DVV-MPC) algorithm for grid-connected cascade H-bridge (CHB) multilevel inverter is presented.

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[Description of a vaginoplasty technique using a peritoneal flap harvested by coelioscopic approach for male-to-female gender affirmations (MtF)].

Ann Chir Plast Esthet

November 2023

Service de chirurgie plastique, reconstructrice et esthétique, centre hospitalo-universitaire de Brest, boulevard Tanguy-Prigent, 29200 Brest, France; Faculté de médecine, université de Brest, 22, rue Camille-Desmoulins, 29238 Brest, France.

Aim: The aim of this article is to provide a comprehensive description of the peritoneal flap technique in male-to-female (MtF) gender affirmation surgery, particularly in cases of insufficient depth after penile inversion vaginoplasty.

Results: Our short-term results reveal that the peritoneal flap vaginoplasty, adapted from the Davydov procedure, has shown significant potential for improving functional and aesthetic outcomes, including the creation of a self-lubricating neovagina. However, the complexity of the procedure requires advanced surgical expertise and appropriate postoperative care.

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Telecommunication has shaped our civilization and fueled economic growth significantly throughout human history [...

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Long-term alterations of pulmonary function (mainly decreased airway conductance and capacity of the lungs to diffuse carbon monoxide (DLCO)) have been described after hyperbaric exposures. However, whether these alterations convey a higher risk for divers' safety has never been investigated before. The purpose of the present pilot study was to assess whether decreased DLCO is associated with modifications of the physiological response to diving.

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We synthesized, thanks to the regiospecific -functionalization using an orthoamide intermediate, two 1,4,7-triazacyclononane derivatives containing an acetate arm and either a methylpyridine or a picolinic acid group, respectively, H and H, as new Ga chelators for potential use in nuclear medicine. The corresponding Ga complexes were synthesized and structurally characterized in solution by H and C NMR. The [Ga()] complex appears to exist in solution as two diasteroisomeric pairs of enantiomers, as confirmed by density functional theory (DFT) calculations, while for [Ga()], a single species is present in solution.

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