804 results match your criteria: "29238 France; Université de Brest[Affiliation]"

A rare complication of a thoracic wound: the pneumopericardium?

Forensic Sci Med Pathol

January 2025

LaTIM, Inserm UMR 1101, 22 Avenue Camille-Desmoulins, CS 93837, Brest cedex, 29238, France.

Pneumopericardium (PPC) is defined by the presence of gas in the pericardial cavity, often leading to cardiac tamponade and a high mortality rate. This report describes a case involving a 33-year-old man found deceased a few meters from a knife, his clothes intact, with no resuscitation attempt made. A knotted scarf was tightly fastened around his neck, without ligature mark.

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This study focuses on developing innovative and eco-friendly purification methods for the isolation of bioactive compounds derived from , a brown abundant macroalga in Djibouti. Three distinct fractions, obtained via liquid-liquid extraction (LLE_FAE), solid-phase extraction (SPE_WE50), and flash chromatography (FC_EtOH20), were selected based on their high phenolic content and antioxidant activities. All fractions were also evaluated for their anti-ageing potential by assessing their ability to inhibit two vital skin-ageing enzymes, tyrosinase and elastase.

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Background: Unhealthy behaviours contributing to cardiovascular issues, diabetes, strokes, and cancer, pose significant health risks. General practitioners (GPs) are pivotal in guiding behaviour change, with Motivational Interviewing (MI) showing promise. MI, developed by William Miller and Stephen Rollnick, aims to enhance motivation for change.

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Rehabilitation is the process of helping people regain or improve lost or impaired function due to injury, illness, or disease. To assist in tracking the progress of patients undergoing rehabilitation, this paper proposes a lightweight graph-based deep-learning model for the automatic assessment of physical rehabilitation exercises. The model takes as input the 3D skeleton sequence of a patient performing a movement and outputs a continuous quality score, as a means for patient supervision that could complement or even substitute the need for ordinary clinical exams.

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Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet.

Biology (Basel)

December 2024

Oniris, Nutrition, Pathophysiology and Pharmacology (NP3), 101 route de Gachet, 44307 Nantes CEDEX 3, France.

Blackcurrant (BC) extract was reported to exert anti-obesity effects. However, it is unknown whether BC extract with a composition close to the totum differentially affects obesity when compared to one of its active compounds. We evaluated the anti-obesity effects of a BC standardized hydro-alcoholic leaf extract (BC-HLE) in an HFD-induced obesity rat model and compared them with quercetin (QUE).

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A templex-based study of the Atlantic Meridional Overturning Circulation dynamics in idealized chaotic models.

Chaos

January 2025

CNRS-IRD-CONICET-UBA, Institut Franco-Argentin d'Études sur le Climat et ses Impacts (IRL 3351 IFAECI), C1428EGA CABA, Argentina.

Significant changes in a system's dynamics can be understood through modifications in the topological structure of its flow in phase space. In the Earth's climate system, such changes are often referred to as tipping points. One of the large-scale components that may pass a tipping point is the Atlantic Meridional Overturning Circulation.

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Cyclic peptides have higher stability and better properties as therapeutic agents than their linear peptide analogues. Consequently, intramolecular click chemistry is becoming an increasingly popular method for the synthesis of cyclic peptides from their isomeric linear peptides. However, assessing the purity of these cyclic peptides by mass spectrometry is a significant challenge, as the linear and cyclic peptides have identical masses.

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Article Synopsis
  • The paper explores the use of Model-Free Predictive Control (MFPC) in power electronic systems, focusing on an improved adaptive integral sliding mode observer (AISMO) to better estimate unknown factors in an ultra-local model (ULM).
  • The proposed AISMO-MFPC aims to enhance control accuracy by estimating system parameters based on current errors, leading to independent control of the system.
  • To achieve lower current ripple, the method incorporates active vector execution time (AVET), allowing for multiple vector selections during a sampling period, which results in faster system responses and reduced harmonics.
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Article Synopsis
  • - The study focuses on using the Marine Predator Algorithm (MPA) to fine-tune the parameters of a power system stabilizer (PSS) to reduce low-frequency oscillations in power systems.
  • - The researchers tested and compared different algorithms using various systems, including the single machine infinite bus (SMIB) and other larger grid configurations, while also validating optimal parameters through real-time simulation.
  • - Results show that the MPA significantly outperforms other optimization methods, achieving up to a 98.62% improvement in performance metrics compared to algorithms like Particle Swarm Optimization and Whale Optimization, confirming its effectiveness through hardware testing.
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This paper presents an active disturbance rejection control (ADRC) approach for three-phase four-legs voltage source inverters (FL-VSIs) in a standalone renewable energy resources (RES)-based islanded microgrid. The key purpose of the proposed approach is to improve the control robustness against load-side disturbances, power supply parameters uncertainties, and faulty operating conditions. Indeed, a notable benefit of ADRC is its ability to operate effectively without the need for precise knowledge of disturbance characteristics or accurate modeling and FL-VSI parameters.

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Bimodal PET/MRI generative reconstruction based on VAE architectures.

Phys Med Biol

December 2024

Université de Lyon, INSA-Lyon, UCBL 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1294, F-69621 Lyon, France.

In this study, we explore positron emission tomography (PET)/magnetic resonance imaging (MRI) joint reconstruction within a deep learning framework, introducing a novel synergistic method.We propose a new approach based on a variational autoencoder (VAE) constraint combined with the alternating direction method of multipliers (ADMM) optimization technique. We explore three VAE architectures, joint VAE, product of experts-VAE and multimodal JS divergence (MMJSD), to determine the optimal latent representation for the two modalities.

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The screening of 166 extracts from tropical marine organisms (invertebrates, macroalgae) and 3 cyclolipopeptides from microorganisms against yeast prions highlighted the potential of Verongiida sponges to prevent the propagation of prions. We isolated the known compounds purealidin Q (), aplysamine-2 (), pseudoceratinine A (), aerophobin-2 (), aplysamine-1 (), and pseudoceratinine B () for the first time from the Wallisian sponge . We then tested compounds - and sixteen other bromotyrosine and bromophenol derivatives previously isolated from Verongiida sponges against yeast prions, demonstrating the potential of -, , , aplyzanzine C (), purealidin A (), psammaplysenes D () and F (), anomoian F (), and N,N-dimethyldibromotyramine ().

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Low-dose emission tomography (ET) plays a crucial role in medical imaging, enabling the acquisition of functional information for various biological processes while minimizing the patient dose. However, the inherent randomness in the photon counting process is a source of noise which is amplified low-dose ET. This review article provides an overview of existing post-processing techniques, with an emphasis on deep neural network (NN) approaches.

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Article Synopsis
  • The work introduces a microwave sensor designed to measure three properties of solid samples: dielectric permittivity, loss tangent, and thickness, using a setup with three resonators sandwiching the sample.
  • The interaction between the sample and resonators alters the sensor's electrical responses, which is analyzed to extract the desired properties.
  • The proposed model was validated through 990 simulations and experimental tests with reference samples, demonstrating effective calibration and accurate multi-parameter sensing.
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Gene expression of Decompression Sickness-resistant rats through a miRnome/transcriptome crossed approach.

Commun Biol

October 2024

Univ Brest, ORPHY's Laboratory, 6 Av Le Gorgeu, CS93837, F-29238, Brest, Cedex, France.

Article Synopsis
  • Researchers studied why some individuals are more prone to decompression sickness (DCS) than others by breeding rats with much higher resistance to DCS than the average rat.
  • They analyzed the genetic expression differences between these resistant rats and a standard rat strain using advanced techniques to uncover important genes and their functions.
  • The study found that pathways related to inflammation and other biological processes play significant roles in how DCS develops.
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Article Synopsis
  • Nickel is a crucial element used in various industries, including medical applications, batteries, and manufacturing, but its excessive usage leads to pollution harmful to humans, animals, and plants.
  • Researchers are developing advanced luminescent and colorimetric sensors for the sensitive detection of nickel, especially in biological and environmental settings.
  • The review focuses on innovations in hybrid receptors, such as metal complexes and metal-organic frameworks (MOFs), which provide superior benefits compared to traditional organic sensors for detecting nickel ions.
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In this paper, a new light event acquisition chain in a three-gamma liquid xenon prototype for medical nuclear imaging is presented. The prototype implements the Multi-Time-Over-Threshold (MTOT) method. This method surpasses the Single-Time-Over-Threshold (STOT) by precisely determining both the number of vacuum ultraviolet (VUV) photons detected by each photomultiplier tube (PMT) and their arrival times for light signal measurement.

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[The benefits of socio-aesthetics in psychiatry: three experiments with adolescents].

Soins Psychiatr

September 2024

Université de Nantes, 9 rue Bias, 44035 Nantes cedex, France; LIEN EA 4685 - Université de Bretagne occidentale, 3 rue des Archives, CS93837, 29238 Brest cedex 3, France. Electronic address:

Adolescents and young adults admitted to the Espace unit at Nantes University Hospital are offered beauty treatments. Although their situations are diverse, they consistently show a decline in self-esteem. These young patients benefit from individual hand and facial treatments, make-up sessions and group workshops.

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A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic.

Sci Data

August 2024

UMR6285 Lab-STICC (Laboratoire des Sciences et Techniques de l'information de la Communication et de la Connaissance), IMT Atlantique, CNRS, 29238, Brest, France.

Political responses to the COVID-19 pandemic led to changes in city soundscapes around the globe. From March to October 2020, a consortium of 261 contributors from 35 countries brought together by the Silent Cities project built a unique soundscape recordings collection to report on local acoustic changes in urban areas. We present this collection here, along with metadata including observational descriptions of the local areas from the contributors, open-source environmental data, open-source confinement levels and calculation of acoustic descriptors.

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Article Synopsis
  • This study evaluates the effectiveness of non-contrast-enhanced 4D MR angiography (NCE-4D-MRA) versus contrast-enhanced 4D MR angiography (CE-4D-MRA) for diagnosing brain arteriovenous malformations (bAVMs), using digital subtraction angiography (DSA) as a reference.
  • Researchers analyzed MRA results from 43 patients and found that NCE-4D-MRA had higher accuracy (0.85) and specificity (95%) than CE-4D-MRA (0.83 accuracy and 85% specificity).
  • The study suggests that NCE-4D-MRA might be a safer diagnostic option for bAVMs, providing
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Article Synopsis
  • The study evaluated the imaging practices for sudden unexpected death in infancy (SUDI) in France, focusing on adherence to guidelines established in 2007.
  • A survey conducted in 35 SUDI referral centers showed that 94.3% of them systematically performed imaging, with significant use of CT and an increase in brain imaging compared to 2015.
  • Despite these advancements, the study concludes that adherence to the French guidelines for SUDI investigations is still incomplete, highlighting the need for further standardization in imaging practices.
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Triiron Complexes Featuring Azadiphosphine Related to the Active Site of [FeFe]-Hydrogenases: Their Redox Behavior and Protonation.

Molecules

July 2024

Laboratoire de Chimie, Electrochimie Moléculaire et Chimie Analytique, UMR 6521 CNRS-Université de Bretagne Occidentale, CS 93837-6 Avenue Le Gorgeu, CEDEX 3, 29238 Brest, France.

Article Synopsis
  • - The study focuses on designing iron clusters with a bimetallic core and multiple protonation sites to better understand polymetallic active sites like the H-cluster in [FeFe]-hydrogenases.
  • - Complexes were synthesized via reactions of hexacarbonyl precursors and mononuclear complexes to incorporate amine functions near the triiron core, aiming to investigate their reactivity and redox properties.
  • - The research identified protonation sites and their interactions, noting that the orientation of protonation processes is influenced by the arrangement of the second coordination sphere, while comparing these triiron species to their dinuclear counterparts.
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Rehabilitation technologies offer promising opportunities for interventions for patients with motor disabilities. However, their use in routine care remains limited due to their high cost and persistent doubts about their cost-effectiveness. Providing solid evidence of the economic efficiency of rehabilitation technologies would help dispel these doubts in order to better take advantage of these technologies.

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Taming 2,2'-biimidazole ligands in trivalent chromium complexes.

Dalton Trans

October 2024

Department of Inorganic and Analytical Chemistry, University of Geneva, 30 quai E. Ansermet, CH-1211 Geneva 4, Switzerland.

Complete or partial replacement of well-known five-membered chelating 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen) ligands with analogous didentate 2,2'-biimidazole (Hbiim) provides novel perspectives for exploiting the latter pH-tuneable bridging unit for connecting inert trivalent chromium with cationic partners. The most simple homoleptic complex [Cr(Hbiim)] and its stepwise deprotonated analogues are only poorly soluble in most solvents and their characterization is limited to some solid-state structures, in which the pseudo-octahedral [CrN] units are found to be intermolecularly connected peripheral N-H⋯X hydrogen bonds. Moreover, the associated high-energy stretching N-H vibrations drastically quench the targeted near infrared (NIR) Cr-based phosphorescence, which makes these homoleptic building blocks incompatible with the design of molecular-based luminescent assemblies.

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