Preliminary Investigation of a Potential Optical Biosensor Using the Diamond™ Nucleic Acid Dye Applied to DNA and Friction Ridge Analysis from Fingerprint Traces.

Developments in science and technology lead to an increasing use of scientific evidence in litigation. Interdisciplinary research can improve current procedures and introduce new ones for the disclosure and examination of evidence. The dactyloscopic trace is used for personal identification by matching minutiae (the minimum required may vary by country) or for extracting DNA material from the trace under investigation.

A two-electron reducing reaction of CO to an oxalate anion: a theoretical study of delocalized (presolvated) electrons in Al(CH)(NH), = 0-2 and = 1-6, clusters.

Presolvated electron possibility in three oxidation states of aluminum - Al(0), Al(I), and Al(II) - has been theoretically investigated for the Al + 6NH, Al(CH) + 5NH, and Al(CH) + 4NH reactions. It has been shown that the metal center adopts a tetrahedral shape for its most stable geometric structure, irrespective of the degree of Al oxidation states. Using different analysis techniques (highest occupied molecular orbital shapes, spin density distributions, and electron delocalization ranges), we showed that presolvated (delocalized) electrons are only formed in the Al(CH)(NH) coordination complexes when 2 ≤ ≤ 4.

Judgments of learning enhance recall for category-cued but not letter-cued items.

Making immediate judgments of learning (JOLs) during study can influence later memory performance, with a common outcome being that JOLs improve cued-recall performance for related word pairs (i.e., positive reactivity) and do not impact memory for unrelated pairs (i.

Unification of Perdew-Zunger self-interaction correction, DFT+U, and Rung 3.5 density functionals.

This Communication presents a unified derivation of three different approximations used in density functional theory (DFT): the Perdew-Zunger self-interaction correction (PZSIC), the Hubbard correction DFT+U, and the Rung 3.5 density functionals. All three approximations can be derived by introducing electron self-interaction into the Kohn-Sham (KS) reference system of noninteracting electrons.

Properties of iconic and visuospatial working memory in pigeons and humans using a location change-detection procedure.

Tests of visuospatial memory following short (<1 s) and medium (1 to 30 s) delays have revealed characteristically different patterns of behavior in humans. These data have been interpreted as evidence for different memory systems operating during short (iconic memory) and long delays (working memory). Leising et al.

Design and implementation of a clinic-to-community, physical activity health promotion model for healthcare providers.

Due to the worldwide burden of noncommunicable disease, the American College of Sports Medicine (ACSM) launched a global health awareness initiative in 2007 called Exercise is Medicine® (EIM®) to create awareness in healthcare providers in promoting physical activity to their patients. To transition awareness into action, Exercise is Medicine Greenville® (EIMG®) launched in 2016 through a first-of-its-kind partnership between a medical school, large healthcare system, and community organization to comprehensively integrate physical activity as a primary prevention strategy into their health system. The EIMG® model connects patients referred by their healthcare provider due to diagnosis of a physical inactivity and/or noncommunicable disease to community partners who provide evidence-based physical activity programs as a population health management strategy.

Dual genetic selection of the theophylline riboswitch with altered aptamer specificity for caffeine.

The aptamer domain of the theophylline riboswitch was randomized to generate a library containing millions of different variants. Dual genetic selection utilizing the cat-upp fusion gene was performed for the library, which successfully led to the identification of a caffeine-specific synthetic riboswitch. When a chloramphenicol-resistance gene was expressed under control of this riboswitch, E.

Developmental thyroid disruption causes long-term impacts on immune cell function and transcriptional responses to pathogen in a small fish model.

Current evidence suggests thyroid hormones (THs) impact development of the immune system, but few studies have explored the connection between the thyroid and immune systems, especially in fish. This is important as some environmental contaminants disrupt TH homeostasis and may thus have negative impacts on the immune system. To determine the long-term consequences of early life stage (ELS) hypothyroidism on immune function, fathead minnows were exposed to the model thyroid hormone suppressant propylthiouracil (PTU) from < 1 to 30 days post hatch.

Replacing hybrid density functional theory: motivation and recent advances.

Density functional theory (DFT) is the most widely-used electronic structure approximation across chemistry, physics, and materials science. Every year, thousands of papers report hybrid DFT simulations of chemical structures, mechanisms, and spectra. Unfortunately, hybrid DFT's accuracy is ultimately limited by tradeoffs between over-delocalization and under-binding.

Calculation of magnetic properties with density functional approximations including rung 3.5 ingredients.

Density functional theory is widely used for modeling the magnetic properties of molecules, solids, and surfaces. Rung-3.5 ingredients, based on the expectation values of nonlocal one-electron operators, are new promising tools for the construction of exchange-correlation functional approximations.

Nonlocal rung-3.5 correlation from the density matrix expansion: Flat-plane condition, thermochemistry, and kinetics.

The rung-3.5 approach to density functional theory constructs nonlocal approximate correlation from the expectation values of nonlocal one-electron operators. This offers an inexpensive solution to hybrid functionals' imbalance between exact nonlocal exchange and local approximate correlation.

Modeling of fusion inhibitor treatment of RSV in African green monkeys.

Respiratory syncytial virus (RSV) is a respiratory infection that can cause serious illness, particularly in infants. In this study, we test four different model implementations for the effect of a fusion inhibitor, including one model that combines different drug effects, by fitting the models to data from a study of TMC353121 in African green monkeys. We use mathematical modeling to estimate the drug efficacy parameters, ε, the maximum efficacy of the drug, and EC, the drug concentration needed to achieve half the maximum effect.

Enhanced DNA detection using a multiple pulse pumping scheme with time-gating (MPPTG).

Fluorescence signal enhancement induced by the binding of intercalators to DNA has been broadly utilized in various DNA detection methods. In most instances the increase in fluorescence intensity is associated with a concomitant increase of fluorescence lifetime. This increase of the fluorescence lifetime presents an additional opportunity to increase detection sensitivity.

Accurate alkynyl radical structures from density functional calculations without Hartree-Fock exchange.

Density functional approximations (DFAs) often suffer from self-repulsion and delocalization errors which are reduced by exact (Hartree-Fock-like) exchange admixture. Oyeyemi and co-workers recently showed that several DFAs with little exact exchange incorrectly predict bent alkynyl radical geometries, giving errors in ab initio composite methods using density functional theory geometries [V. B.

Reducing density-driven error without exact exchange.

The errors in density functional theory (DFT) calculations can be decomposed into contributions from the exchange-correlation density functional approximation (DFA), and contributions from the approximate electron density generated by that DFA. Standard "semilocal" DFAs have large density-driven delocalization errors for dissociating bonds, radical complexes, metal-ligand complexes, reaction intermediates, and reaction barriers. Several recent studies use Hartree-Fock exchange to reduce these density-driven errors.

The concreteness effect on judgments of learning: Evaluating the contributions of fluency and beliefs.

Researchers have often determined how cues influence judgments of learning (JOLs; e.g., concrete words are assigned higher JOLs than are abstract words), and recently there has been an emphasis in understanding why cues influence JOLs (i.

Risk terrain modeling predicts child maltreatment.

As indicated by research on the long-term effects of adverse childhood experiences (ACEs), maltreatment has far-reaching consequences for affected children. Effective prevention measures have been elusive, partly due to difficulty in identifying vulnerable children before they are harmed. This study employs Risk Terrain Modeling (RTM), an analysis of the cumulative effect of environmental factors thought to be conducive for child maltreatment, to create a highly accurate prediction model for future substantiated child maltreatment cases in the City of Fort Worth, Texas.

Left-right correlation in coupled F-center defects.

This work explores how left-right correlation, a textbook problem in electronic structure theory, manifests in a textbook example of electrons trapped in crystal defects. I show that adjacent F-center defects in lithium fluoride display symptoms of "strong" left-right correlation, symptoms similar to those seen in stretched H2. Simulations of UV/visible absorption spectra qualitatively fail to reproduce experiment unless left-right correlation is taken into account.

Topological analysis of the electron delocalization range.

The electron delocalization range function EDR( r→;d) (Janesko et al., J. Chem.

A triazine-based BODIPY trimer as a molecular viscometer.

Photophysical behaviour of a novel trimeric BODIPY rotor with a high extinction coefficient is reported. Steady state and time resolved fluorescence measurements established that the trimer could be used as a viscometer for molecular solvents, membrane-like environments and several cancer cell lines.

Evidence of Energy Transfer from Tryptophan to BSA/HSA Protected Gold Nanoclusters.

This work reports on the chromophores interactions within protein-protected gold nanoclusters. We conducted spectroscopic studies of fluorescence emissions originated from gold nanoclusters and intrinsic tryptophan (Trp) in BSA or HSA proteins. Both, steady state fluorescence and lifetime measurements show a significant Forster resonance energy transfer (FRET) from Trp to the gold nanocluster.

Evidence of energy transfer from tryptophan to BSA/HSA protected gold nanoclusters.

This work reports on the chromophores interactions within protein-protected gold nanoclusters. We conducted spectroscopic studies of fluorescence emissions originated from gold nanoclusters and intrinsic tryptophan (Trp) in BSA or HSA proteins. Both steady state fluorescence and lifetime measurements showed a significant Forster Resonance Energy Transfer (FRET) from Trp to the gold nanocluster.

Feature-positive discriminations during a spatial-search task with humans.

During feature-positive operant discriminations, a conditional cue, X, signals whether responses made during a second stimulus, A, are reinforced. Few studies have examined how landmarks, which can be trained to control the spatial distribution of responses during search tasks, might operate under conditional control. We trained college students to search for a target hidden on a computer monitor.

Need to train your rat? There is an App for that: a touchscreen behavioral evaluation system.

The increasing demand for highly automated and flexible tasks capable of assessing visual learning and memory in nonhuman animals has led to the exciting development of a wide array of prefabricated touchscreen-equipped systems. However, the high cost of these prefabricated systems has led many researchers to develop or modify their own preexisting equipment. We developed a freely downloadable App, the Touchscreeen Behavioral Evaluation System (TBES) for use in conjunction with an iPad (Apple, Cupertino, California) as an alternative to prefabricated touchscreen systems.