Conformational effects in the identification and quantification of ketohydroperoxides in the oxidation of -pentane.

Stereochemistry plays a key role in both fundamental chemical processes and the dynamics of a large set of molecular systems of importance in chemistry, medicine and biology. Predicting the chemical transformations of organic precursors in such environments requires detailed kinetic models based on laboratory data. Reactive intermediates play a critical role in constraining the models but their identification and especially their quantification remain challenging.

[A national survey from the French Society of Pathology on research and application of artificial intelligence in pathology].

The 2030 French Innovation Healthcare national plan defined "Digital Healthcare" as one of its priority. The deployment of digital pathology and artificial intelligence fits perfectly into this framework. Therefore we evaluated the pathologist's interest in those fields by conducting an online survey among members of the French Society of Pathology, mainly composed of senior pathologists and trainees (n=2301).

Mechanistic study of micropollutants rejection by nanofiltration of a natural water.

A natural water sampled after a sand filtration step and spiked with four organic micropollutants (metolachlor ESA, metolachlor NOA, desethylatrazine and metaldehyde) was treated by a loose nanofiltration membrane. The Steric, Electric, and Dielectric model (SEDE model) was then used to predict the separation performance of the membrane towards the various ions and micropollutants in the water matrix in order to study the transport mechanism of ions and micropollutants through the membrane. The SEDE model was found to satisfactorily predict the rejection sequences of inorganic anions and cations, as well as neutral (desethylatrazine and metaldehyde) and charged (metolachlor ESA and metolachlor NOA) micropollutants.

Linking structural and functional changes during healthy aging and semantic dementia using multilayer brain network analysis.

Healthy aging is characterized by frontal and diffuse brain changes, while certain age-related pathologies such as semantic dementia will be associated with more focal brain lesions, particularly in the temporo-parietal regions. These changes in structural integrity could influence functional brain networks. Here we use multilayer brain network analysis on structural (DWI) and functional (fMRI) data in younger and older healthy individuals and patients with semantic dementia.

Pulmonary and systemic effects of inhaled crystalline silica in the HOCl-induced mouse model of systemic sclerosis: An experimental model of Erasmus syndrome.

Occupational exposure to crystalline silica is etiologically linked to an increased incidence of systemic sclerosis (SSc), also called Erasmus syndrome. The underlying mechanisms of silica-related SSc are still poorly understood. We demonstrated that early and repeated silica exposure contribute to the severity of SSc symptoms in the hypochloric acid (HOCl)-induced SSc mouse model.

SMCHD1 genetic variants in type 2 facioscapulohumeral dystrophy and challenges in predicting pathogenicity and disease penetrance.

The molecular diagnosis of type 1 facioscapulohumeral muscular dystrophy (FSHD1) relies on the detection of a shortened D4Z4 array at the 4q35 locus. Until recently, the diagnosis of FSHD2 relied solely on the absence of a shortened D4Z4 allele in clinically affected patients. It is now established that most FSHD2 cases carry a heterozygous variant in the SMCHD1 gene.

Early safety after TAVR according to VARC-3 criteria: incidence, predictors, and clinical impact.

Introduction And Objectives: The Valve Academic Research Consortium (VARC)-3 definition of the early safety (ES) composite endpoint after transcatheter aortic valve replacement (TAVR) lacks clinical validation. The aim of this study was to determine the incidence, predictors, and clinical impact of ES after TAVR as defined by VARC-3 criteria.

Methods: We performed a multicenter study including 10 078 patients with severe aortic stenosis undergoing transarterial TAVR.

Nuclear Quadrupolar Resonance Structural Characterization of Halide Perovskites and Perovskitoids: A Roadmap from Electronic Structure Calculations for Lead-Iodide-Based Compounds.

Metal halide perovskites, including some of their related perovskitoid structures, form a semiconductor class of their own, which is arousing ever-growing interest from the scientific community. With halides being involved in the various structural arrangements, namely, pure corner-sharing MX (M is metal and X is halide) octahedra, for perovskite networks, or alternatively a combination of corner-, edge-, and/or face-sharing for related perovskitoids, they represent the ideal probe for characterizing the way octahedra are linked together. Well known for their inherently large quadrupolar constants, which is detrimental to the resolution of nuclear magnetic resonance spectroscopy, most abundant halide isotopes (Cl, Br, I) are in turn attractive for magnetic field-free nuclear quadrupolar resonance (NQR) spectroscopy.

FRET-based mesoporous organosilica nanoplatforms for and anticancer two-photon photodynamic therapy.

We report the synthesis of multifunctional periodic mesoporous organosilica nanoparticles (PMO NPs) with substantial two-photon absorption properties and targeting capability for two-photon excitation fluorescence (TPEF) and photodynamic therapy (TPE-PDT). Prepared using an adapted sol-gel synthesis, the nanoplatforms integrated two silylated chromophores in their three-dimensional matrix to maximize non-radiative Förster resonance energy transfer from a high two-photon absorption fluorophore donor to a porphyrin derivative acceptor, leading to an enhanced generation of reactive oxygen species. Combinations of biodegradable and non-biodegradable bis(triethoxysilyl)alkoxysilanes were employed for the synthesis of the NPs, and the corresponding photophysical studies revealed high efficiency levels of FRET.

A comprehensive dataset of near infrared spectroscopy measurements to predict nitrogen and carbon contents in a wide range of tissues from plants grown under contrasted environments.

Winter oilseed rape (WOSR, L.) is the third largest oil crop worldwide that also provides a source of high quality plant-based proteins. Nitrogen (N) and carbon (C) play a key role in plant growth.

Profiles of the maternal occupational exposome during pregnancy and associations with intrauterine growth: Analysis of the French Longitudinal Study of Children - ELFE study.

Background: Numerous agents in the workplace are suspected of impairing fetal growth. To date, no epidemiological studies have specifically described the occupational exposome during pregnancy.

Objective: The objectives were to determine maternal occupational exposome profiles and study their associations with intrauterine growth characteristics measured by small for gestational age (SGA), birthweight (BW), and head circumference (HC).

Exploring the Complex Mechanisms of Isoflavones: From Cell Bioavailability, to Cell Dynamics and Breast Cancer.

In Western countries, the increase in the consumption of soy-derived products raises the population's exposure to isoflavones. These molecules, present in many foods, have numerous effects on the body's cells, including regulation of the transcription and epigenetics, cell signaling, cell cycle, cell growth, apoptosis, and oxidative stress. However, despite the multitude of studies conducted, on these compounds, it remains difficult to draw definitive conclusions regarding their safety or dangerousness in the diet.

Primary central nervous system lymphoma of the spinal cord: A LOC network cohort study.

Purpose: Primary central nervous system lymphoma (PCNSL) mainly affects the brain (>90% cases); there are very little data pertaining to PCNSL involving the spinal cord.

Methods: We retrospectively selected from the French LOC network database adult immunocompetent patients diagnosed with PCNSL involving the spinal cord between 2011 and 2022.

Results: Of the 2043 patients records retrieved from the database, 16 patients (median age: 62.

[Epigenetics and cancer: the role of DNA methylation].

Alterations in DNA methylation profiles are typically found in cancer cells, combining genome-wide hypomethylation with hypermethylation of specific regions, such as CpG islands, which are normally unmethylated. Driving effects in cancer development have been associated with alteration of DNA methylation in certain regions, inducing, for example, the repression of tumor suppressor genes or the activation of oncogenes and retrotransposons. These alterations represent prime candidates for the development of specific markers for the detection, diagnosis and prognosis of cancer.

β-Lactam Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus Infective Endocarditis.

Importance: Infective endocarditis (IE) caused by Staphylococcus aureus is associated with high mortality, approximately 20% to 30%, mostly in the first month, with no improvement in recent decades. Current opinion is that antistaphylococcal penicillin and cefazolin are equally effective in treating methicillin-susceptible S aureus (MSSA) IE, and both are recommended as possible first-line treatments. Most MSSA strains carry the β-lactamase blaZ gene, and some blaZ-positive strains exhibit an inoculum effect, meaning increased minimum inhibitory concentrations at high inoculum.

VUV photochemistry of cyclopropenone (c-CHO): formation rate and abundance ratios of propynal (HCCCHO) and propadienone (CHCCO).

The distribution of isomeric species in the interstellar medium cannot be directly related to their relative energetic stabilities but more to their mechanisms of formation and evolution. The abundances of the three isomers of CHO, cyclopropenone, propynal and propadienone, are an example among many other interstellar species wherein kinetic effects control their presence in astrophysical regions. To date, only propynal and cyclopropenone, the two less stable isomers of propadienone, have been detected in the interstellar medium.

[Cataract surgery training in France: Analysis of the results of the European Board of Ophthalmology survey in the French cohort].

Objective: This study aims to present and analyze the results of the French cohort in a European Board of Ophthalmology (EBO) survey on cataract surgical training in Europe, highlighting the particularities of French training.

Materials And Methods: A 23-question electronic questionnaire was sent to interns applying for the EBO examination from 2018 to 2022. Responses from French participants were specifically collected and analyzed.

Mycobiome analyses of critically ill COVID-19 patients.

Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome in patients with COVID-19 has been associated with lung fungal dysbiosis, evidenced by reduced microbial diversity and colonization. Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality.

Immune transcriptomic profile in adult female pigs: dominance status has more influence than environmental enrichment.

Background: Assessing farm animals' welfare is crucial, yet practical physiological tools are still lacking. In this study, we tested whether the peripheral blood mononuclear cell (PBMC) transcriptome shows variations in association with sows' welfare. To do this, we compared animals whose welfare states were assumed to differ due to their lives in more or less enriched environments and to their different dominance statuses.

Methodological expectations for demonstration of health product effectiveness by observational studies.

The issue of assessing the effectiveness of health technologies (drugs, devices, etc.) through observational studies is becoming increasingly important as registration and market access agencies consider them in their evaluation process. In this context, observational studies must be able to provide real demonstrations of a level of reliability comparable to those produced by the conventional randomized controlled trial (RCT) approach.

Evaluation of efficacy and safety of rituximab in patients with progressive interstitial lung disease (ILD) with inflammatory component (EvER-ILD2): A multicentre double-blind placebo-controlled randomized trial.

Introduction: Progressive interstitial lung diseases (ILDs) are rare but severe diseases, with high mortality and morbidity, with no effective pharmacological treatment allowing for long-term remission, and therefore no clear therapeutic recommendations. Several ILDs present inflammatory components (ILDic), which may justify the use of anti-inflammatory and immunosuppressive drugs, as first-step therapy. Except for systemic sclerosis (SSc)-ILD and sarcoidosis, the evidence in favor of this approach is very weak.

Yawn Contagion and Modality-Matching in the Female-Bonded Society of Geladas (Theropithecus gelada).

Behavioral contagion is widespread in primates, with yawn contagion (YC) being a well-known example. Often associated with ingroup dynamics and synchronization, the possible functions and evolutionary pathways of YC remain subjects of active debate. Among nonhuman animals, geladas (Theropithecus gelada) are the only species known to occasionally emit a distinct vocalization while yawning.

Phosphorus-containing polycarbosilazanes: synthesis dehydrocoupling catalysis and flame-retardant properties.

The barium complex [Ba{N(SiMe)}] has been used to catalyse the dehydropolymerisation of the phosphine-functionalised hydrosilane 4-PhP-CHSiH (A) with the α,ω-diamine 1,4-(CHNHMe)-CH (C), for the production of -[Si(4-CHPPh)H-N(Me)CH-CH-CHN(Me)]- polycarbosilazanes that contain dangling phosphino groups along the polymer backbone. The comonomers A and C, specifically prepared for this purpose and comprehensively characterised, lend themselves well to barium-promoted dehydrocoupling catalysis. They allow for the formation of linear, amine-capped polymers with molecular weights in the range 4000-8000 g mol, as estimated by DOSY and H end-group NMR analyses.

Evaluation of Intestinal Barrier Function after Exposure to Digested Pea Ingredients─Food Matrix Effect.

Dietary fibers (DF) are important components of human and animal diets. However, they can decrease protein digestibility and absorption and thus the nutritional value of a food. The aim of this study was to investigate how the form of delivery of pea DF impacted the integrity of the intestinal barrier and, thereby, the potential absorption of molecules.

Of perfluorinated aryllead(II) complexes.

The pentafluorophenyl moiety CF was succesfully employed for the first time in lead(II) chemistry. We are reporting on the stable and soluble organolead(II) polymer [Pb(CF)(dx)] (dx = dioxane). An example of a Pb(II) "ate" complex paired with a trimetallic magnesium cation is also presented.