Healthcare costs associated with receipt of effective mental healthcare coverage in individuals with moderate or severe symptoms of anxiety and depression.

Background: Effective mental healthcare coverage (EMHC) is an important health system performance indicator of a population's mental healthcare needs. This study aims to assess the factors and healthcare costs associated with the receipt of EMHC for anxiety and depression.

Methods: This study draws on data from participants from Alberta's Tomorrow Project with moderate or severe symptoms of anxiety and depression during the first wave of the COVID-19 pandemic (2020) with available medico-administrative and complete data [n = 720].

Measurement Properties of the Dysphagiameter for the Assessment of Dysphagia in Oculopharyngeal Muscular Dystrophy.

Oculopharyngeal muscular dystrophy (OPMD) is a rare late-onset muscle disease with progressive dysphagia as a major symptom. The Dysphagiameter is a newly developed patient-reported outcome measure (PROM) to assess the severity of dysphagia and its impact in patients with OPMD. This article reports on item reduction and a first assessment of the Dysphagiameter's psychometrics properties, in a French and English-speaking population of individuals with OPMD.

Thoughts on the Rational Design of MOF-Guest Interactions for Future Intelligent Materials.

The MOF-guest relationship is broken down in elementary phases, descriptors, and parameters. These descriptors and parameters allow precise descriptions of processes, whether they occur at the point when the guest enters the MOF, during the stay, or at the point of exiting. Description of these three phases is possible according to the location of the guest inside the MOF, the activity between MOF and guest, whether stimuli can be used, and whether a selective action can be exercised.

Construction, monitoring, and efficiency of a biofilter treating a high flow, lean, landfill gas.

The City of Montreal has committed to achieve carbon neutrality by 2050. To meet this commitment, the city has adopted the Climate Plan 2020-2030, which includes the treatment of landfill gas (LFG). Within this framework, this research aimed to investigate the efficiency of a biofilter designed to treat high volumes of low-concentration LFG collected from lateral trenches at the Complexe Environnemental de Saint-Michel (CESM) in Montreal.

New generalized metric based on branch length distance to compare B cell lineage trees.

The B cell lineage tree encapsulates the successive phases of B cell differentiation and maturation, transitioning from hematopoietic stem cells to mature, antibody-secreting cells within the immune system. Mathematically, this lineage can be conceptualized as an evolutionary tree, where each node represents a distinct stage in B cell development, and the edges reflect the differentiation pathways. To compare these lineage trees, a rigorous mathematical metric is essential.

A robust deep learning attack immune MRAM-based physical unclonable function.

The ubiquitous presence of electronic devices demands robust hardware security mechanisms to safeguard sensitive information from threats. This paper presents a physical unclonable function (PUF) circuit based on magnetoresistive random access memory (MRAM). The circuit utilizes inherent characteristics arising from fabrication variations, specifically magnetic tunnel junction (MTJ) cell resistance, to produce corresponding outputs for applied challenges.

Enhanced train-the-trainer program for registered nurses and social workers to apply the founding principles of primary care in their practice: a pre-post study.

Background: A train-the-trainer approach can effectively support the integration of new practice standards for health and social services professionals. This study describes the effects of an enhanced train-the-trainer program to support registered nurses and social workers working in primary care clinics in their understanding of the fundamental principles of primary care.

Methods: We implemented an enhanced train-the-trainer program for registered nurses and social workers in six primary care clinics.

Grating Bio-Microelectromechanical Platform Architecture for Multiple Biomarker Detection.

A label-free biosensor based on a tunable MEMS metamaterial structure is proposed in this paper. The adopted structure is a one-dimensional array of metamaterial gratings with movable and fixed fingers. The moving unit of the optical detection system is a component of the MEMS structure, driven by the surface stress effect.

Selective Chirality-Driven Photopolymerization of Diacetylene Crystals.

Crystal engineering of two diacetylene monomers was achieved by branching two chiral groups [R = PhC*MeNH(CO)CH] exhibiting an enantiopure configuration of ,-() and an achiral ,--isomer (). The X-ray structures of and reveal the presence of supramolecular arrangements driven by intermolecular H-bonding. A significant intermolecular closer proximity in than that in is depicted, ultimately resulting in a slow thermal (days) and swift (min) photochemical polymerization of to form , whereas is unreactive.

Acute natural killer cells response to a continuous moderate intensity and a work-matched high intensity interval exercise session in metastatic cancer patients treated with chemotherapy.

Background: It has been suggested that the acute natural killer (NK) cell response to aerobic exercise might contribute to the tumor suppressor effect of regular exercise observed in preclinical studies. Moreover, because this response is modulated by exercise intensity, high-intensity intervals exercise (HIIE) might represent an interesting therapeutic approach in cancer patients. However, this immune response remains unstudied in cancer patients currently undergoing chemotherapy.

Distributed Statistical Analyses: A Scoping Review and Examples of Operational Frameworks Adapted to Health Analytics.

Background: Data from multiple organizations are crucial for advancing learning health systems. However, ethical, legal, and social concerns may restrict the use of standard statistical methods that rely on pooling data. Although distributed algorithms offer alternatives, they may not always be suitable for health frameworks.

Singlet oxygen is an emissive ligand.

Unprecedented experimental evidence shows that gaseous singlet oxygen (O) acts as an emissive ligand following collisional photosensitization. This evidence was obtained by monitoring O phosphorescence intensity at ≈1275-1280 nm and the excited state lifetime of singlet oxygen generated by known tetraphenylporphyrin photosensitizers, while varying the atmospheric environment.

Local climate, air quality and leaf litter cover shape foliar fungal communities on an urban tree.

Foliar fungi on urban trees are important for tree health, biodiversity and ecosystem functioning. Yet, we lack insights into how urbanization influences foliar fungal communities. We created detailed maps of Stockholm region's climate and air quality and characterized foliar fungi from mature oaks (Quercus robur) across climatic, air quality and local habitat gradients.

Whole blood multiplex measurements using electrochemical aptamer-based biosensors.

Simultaneous measurements of various molecules ("multiplex") using electrochemical biosensors typically require multiple electrode implementations, which for neonates, hemophiliacs, is problematic. Here, we introduce the oxazine ATTO 700 into electrochemical aptamer-based biosensors to achieve "true" multiplex, continuous and real-time measurements of two different molecules in undiluted whole blood using a single electrode.

Sexual well-being among partnered adults and couples over 60: a scoping review.

Introduction: Although society still holds age-related stereotypes dismissing the sexuality of aging individuals, older adults remain sexually active and find sexuality to be an important part of their quality of life. Primarily oriented toward a biomedical and dysfunctional lens, prior research neglected the subjective well-being of elderly individuals, especially partnered adults and couples aged 60 years or more. Shedding a more positive light on this area of life could promote older individuals' and couples' sexual well-being.

What are the views of Quebec and Ontario citizens on the tiebreaker criteria for prioritizing access to adult critical care in the extreme context of a COVID-19 pandemic?

Background: The prioritization protocols for accessing adult critical care in the extreme pandemic context contain tiebreaker criteria to facilitate decision-making in the allocation of resources between patients with a similar survival prognosis. Besides being controversial, little is known about the public acceptability of these tiebreakers. In order to better understand the public opinion, Quebec and Ontario's protocols were presented to the public in a democratic deliberation during the summer of 2022.

[L'impossible quête des préposées aux bénéficiaires pour actualiser la bientraitance visée dans les politiques publiques du Québec.The impossible quest of health care aides to actualize the good treatment targeted in Quebec's public policies.].

Notre recherche visait à mettre en lumière les pratiques bientraitantes des préposées aux bénéficiaires en milieux d'hébergement pour aînés au Québec. L'objet de l'article est de faire ressortir la dichotomie entre les définitions de la bientraitance et son opérationnalisation. Dans la première partie, la notion de bientraitance dans le cadre de deux politiques gouvernementales québécoises est présentée.

The Chinese translation and cross-cultural adaptation of PRISMA-7 questionnaire: an observational study to establish the accuracy, reliability and validity.

Background: Frailty is a health condition linked to adverse health outcomes and lower life quality. The PRISMA-7, a 7-item questionnaire from the Program on Research for Integrating Services for the Maintenance of Autonomy (PRISMA), is a validated case-finding tool for frailty with good sensitivity and specificity. This study aimed to translate, culturally adapt, and validate the PRISMA-7 questionnaire for Chinese use.

Mass-spring model for acoustic metamaterials consisting of a compact linear periodic array of dead-end resonators.

This paper presents a mass-spring model to predict the normal incidence acoustic response of a metamaterial composed of a compact linear periodic array of dead-end resonators. The dead-end resonators considered are ring-shaped Helmholtz resonators. The model is based on a mass-spring analogy and considers the thermoviscous losses in the metamaterial following an effective fluid approach.

A unified filtering method for estimating asymmetric orientation distribution functions.

Numerous filtering methods have been proposed for estimating asymmetric orientation distribution functions (ODFs) for diffusion magnetic resonance imaging (dMRI). It can be hard to make sense of all these different methods, which share similar features and result in similar outputs. In this work, we disentangle these many filtering methods proposed in the past and combine them into a novel, unified filtering equation.

Ultrasensitive detection of vital biomolecules based on a multi-purpose BioMEMS for Point of care testing: digoxin measurement as a case study.

Rapid and label-free detection of very low concentrations of biomarkers in disease diagnosis or therapeutic drug monitoring is essential to prevent disease progression in Point of Care Testing. For this purpose, we propose a multi-purpose optical Bio-Micro-Electro-Mechanical-System (BioMEMS) sensing platform which can precisely measure very small changes of biomolecules concentrations in plasma-like buffer samples. This is realized by the development of an interferometric detection method on highly sensitive MEMS transducers (cantilevers).

Experimental and Computational Studies for the Synthesis of Functionalized Cyclopropanes from 2-Substituted Allylic Derivatives with Ethyl Diazoacetate.

The catalytic asymmetric synthesis of highly functionalized cyclopropanes from 2-substituted allylic derivatives is reported. Using ethyl diazo acetate, the reaction, catalyzed by a chiral ruthenium complex (Ru(II)-Pheox), furnished the corresponding easily separable cis and trans cyclopropanes in moderate to high yields (32-97 %) and excellent ee (86-99 %). This approach significantly extends the portfolio of accessible enantioenriched cyclopropanes from an underexplored class of olefins.

Relative timing information and orthology in evolutionary scenarios.

Background: Evolutionary scenarios describing the evolution of a family of genes within a collection of species comprise the mapping of the vertices of a gene tree T to vertices and edges of a species tree S. The relative timing of the last common ancestors of two extant genes (leaves of T) and the last common ancestors of the two species (leaves of S) in which they reside is indicative of horizontal gene transfers (HGT) and ancient duplications. Orthologous gene pairs, on the other hand, require that their last common ancestors coincides with a corresponding speciation event.