1 results match your criteria: "250 College St. R130[Affiliation]"
Epigenetic assimilation in the aging human brain.
Genome Biol
April 2016
Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College St. R130, Toronto, Ontario, M5T 1R8, Canada.
Background: Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages of human life.
Results: We find that brain tissues of older individuals (>75 years) become more similar to each other, both epigenetically and transcriptionally, compared with younger individuals.