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Patterns of cytokine and chemokine expression in peripheral blood of patients with COVID-19 associated with disease severity.
Int J Immunopathol Pharmacol
March 2023
Department of Microbiology, 249307National Centre of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Objectives: Cytokine dysregulation has been proposed as one of the main culprits for severe COVID-19 and poor prognosis. We examined the parallel presence of lymphopoietic, proinflammatory, Th1, Th2, regulatory cytokines, and chemokines in the serum of 47 patients with mild, moderate, and severe COVID-19 and evaluated the association between cytokine concentrations and disease severity.
Methods: A multiplex quantitative cytokine analysis ProcartaPlex™ immunoassay was applied, using the Luminex 200X detection system (Invitrogen).