2 results match your criteria: "223 - 3075 Hospital Gate[Affiliation]"

Diagnosis and Management of Atypical Femoral Fractures and Medication-Related Osteonecrosis of the Jaw in Patients with Osteoporosis.

Endocrinol Metab Clin North Am

December 2024

Division of Endocrinology and Metabolism, McMaster University, 223 - 3075 Hospital Gate, Oakville, Ontario L6M 1M1, Canada. Electronic address:

Article Synopsis
  • Anti-osteoporosis treatments lower fracture risk but can cause rare side effects with long-term use, like atypical femoral fractures (AFFs) and medication-related osteonecrosis of the jaw (MRONJ).
  • AFFs are more common after long-term use of bisphosphonates, while MRONJ is more prevalent in cancer patients receiving high doses of antiresorptive therapy.
  • Effective treatments exist for both complications, and a personalized treatment plan with careful monitoring is recommended.
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The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations.

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