3 results match your criteria: "22-062 Lineberger Cancer Center[Affiliation]"
Independent evolution of human immunodeficiency virus type 1 env V1/V2 and V4/V5 hypervariable regions during chronic infection.
J Virol
May 2007
University of North Carolina at Chapel Hill, 22-062 Lineberger Cancer Center, CB#7295, Chapel Hill, NC 27599-7295, USA.
Using DNA heteroduplex tracking assays, we characterized human immunodeficiency virus type 1 env V4/V5 genetic populations in multiple blood plasma samples collected over an average of 7 months from 24 chronically infected human subjects. We observed complex and dynamic V4/V5 genetic populations in most subjects. Comparisons of V4/V5 and V1/V2 population changes over the course of the study showed that major shifts in genetic populations frequently occurred in one region but not the other, and these observations were independently confirmed in one subject by single-genome sequencing.
View Article and Find Full Text PDFMultiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1.
J Virol
October 2004
University of North Carolina at Chapel Hill, 22-062 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599-7295, USA.
Article Synopsis
- HIV-1 exists as a diverse population of viral variants, particularly noticeable in chronically infected individuals, but during acute HIV-1 infections, there can be multiple viral variants circulating despite the low probability of infection.
- A study analyzing blood plasma samples from 26 individuals with acute HIV-1 infection found that half had multiple V1/V2 viral variants, contradicting the assumption that only a few variants are transmitted during initial infection.
- The research also indicated that while various viral variants are present during acute infection, they show rapid penetration into different bodily compartments (like seminal plasma and cerebrospinal fluid), suggesting factors like transient hyperinfectiousness or the inefficiency of infecting cells might influence both the transmission probability and the variety
Using HIV-1 sequence variability to explore virus biology.
Virus Res
August 2001
UNC Center for AIDS Research, University of North Carolina at Chapel Hill, 22-062 Lineberger Cancer Center, CB# 7295, Chapel Hill, NC 27599-7295, USA.
Human immunodeficiency virus type 1 (HIV-1) only recently established an epidemic world-wide infection in the human population. The virus persists in the human host through active replication and is able to avoid clearance by the immune system. Active replication is an important component of the rapid evolutionary potential of HIV-1, a potential which manifests itself in the evolution of immune escape variants, drug resistant variants, and variants with the ability to use different cell surface coreceptors in conjunction with CD4.
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