2 results match your criteria: "2.Sechenov First Moscow State Medical University[Affiliation]"
The particulars of certain drugs' effect on the endogenous coenzyme Q10 plasma level in patients with cardiovascular diseases.
Drug Metab Pers Ther
June 2020
2.Sechenov First Moscow State Medical University, Trubetskaya 8, bld. 2, Moscow, 119991, Russian Federation.
Article Synopsis
- Coenzyme Q10 (CoQ10) levels are significantly lower in patients with cardiovascular diseases (CVDs) compared to healthy individuals.
- Administration of atorvastatin leads to a further decrease in CoQ10 levels, while amlodipine and ethoxidol are linked to increases in CoQ10 levels.
- The study recommends adjusting therapy for patients to maintain appropriate CoQ10 levels and prevent negative health effects associated with its deficiency.
It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder.
View Article and Find Full Text PDF