Development and Implementation of a Cancer Quality Index in Queensland, Australia: A Tool for Monitoring Cancer Care.

Purpose: Many cancer-specific assessment tools to measure health care performance have been developed. However, reporting on quality indicators at a population level is uncommon. We describe the development and implementation of a Cancer Quality Index (CQI) and examine the sensitivity of the index to detect change over time.

A comparison of different modes of pneumatic compression on muscle tissue oxygenation: An intraparticipant, randomised, controlled volunteer study.

Intermittent pneumatic compression (IPC) to the lower limbs is widely used as a mechanical means to prevent deep vein thrombosis in hospitalised patients. Due to a theoretical concern about impairing blood flow, thromboembolic-deterrent stockings and IPC are considered contraindicated for patients with peripheral vascular diseases by some clinicians. This study assessed whether IPC would alter peripheral limb muscle tissue oxygenation (StO), and whether such changes were different during 10 minutes of sequential and single-compartment compressions.

To Whom Do We Confide Our Secrets?

Although prior work has examined secret keeping, no prior work has examined who gets told secrets. Five studies find compassion and assertiveness predict having secrets confided in oneself (as determined by both self- and peer reports), whereas enthusiasm and politeness were associated with having fewer secrets confided. These results bolster suggestions that interpersonal aspects of personality (which can fit a circumplex structure) are driven by distinct causal forces.

SMART Arm Training With Outcome-Triggered Electrical Stimulation in Subacute Stroke Survivors With Severe Arm Disability: A Randomized Controlled Trial.

Background: Stroke survivors with severe upper limb disability need opportunities to engage in task-oriented practice to achieve meaningful recovery.

Objective: To compare the effect of SMART Arm training, with or without outcome-triggered electrical stimulation to usual therapy, on arm function for stroke survivors with severe upper limb disability undergoing inpatient rehabilitation.

Methods: A prospective, multicenter, randomized controlled trial was conducted with 3 parallel groups, concealed allocation, assessor blinding and intention-to-treat analysis.

Fidelity of Occupational Performance Coaching: Importance of Accuracy in Intervention Identification.

Establishing fidelity processes and measures is an important step in the development of interventions. Accurate referencing, naming of interventions and robust discussion of deviations from the theories, methods or terminology underpinning interventions support the fidelity of future applications of interventions in research and clinical settings. This commentary clarifies the establishment of fidelity for Occupational Performance Coaching (OPC) in relation to a recent article on this topic by Dunn and colleagues.

Toward a Comprehensive Understanding of Intergroup Contact: Descriptions and Mediators of Positive and Negative Contact Among Majority and Minority Groups.

Positive contact predicts reduced prejudice, but negative contact may increase prejudice at a stronger rate. The current project builds on this work in four ways: establishing an understanding of contact that is grounded in subjective experience, examining the affective mediators involved in the negative contact-prejudice relationship, extending research on the effects of positive and negative contact to minority groups, and examining the contact asymmetry experimentally. Study 1 introduced anger as a mediator of the relationships between positive and negative contact and prejudice among White Americans ( N = 371), using a contact measure that reflected the frequency and intensity of a wide range of experiences.

The Mandate of the Collective: Apology Representativeness Determines Perceived Sincerity and Forgiveness in Intergroup Contexts.

The sincerity of an apology is often critical for it to be viewed positively by victims. For collective apologies, we argue that sincerity takes on a particular meaning: It is a function of the apology's perceived representativeness for the offender group's will or sentiment. Consistent with this notion, when an apologetic (vs.

Boozy Nights and Violent Fights: Perceptions of Environmental Cues to Violence and Crime in Licensed Venues.

This article examines perceptions of environmental cues to crime, violence, and injuries in barroom settings, and how they differ between bar fight participants and non-participants. Bouncer friendliness, patron sex composition, and room temperature were chosen as experimental variables based on three criteria: (a) emerged as a theme in bar user focus groups, (b) unclear effects in the literature, and (c) policy relevant and easy to modify. These experimental variables were manipulated in written vignettes set in a bar.

Health workers' support for hepatitis C treatment uptake among clients with a history of injecting.

Hepatitis C virus is stigmatised because of its association with injecting drug use. Although treatment is available, uptake remains low, especially among people who inject drugs. Ninety health workers completed a survey assessing attitudes towards people who inject drugs and support for treatment for three client scenarios: one who stopped injecting, one on methadone, and one continuing to inject.

Exploring Workforce Participation Patterns and Chronic Diseases Among Middle-Aged Australian Men and Women Over the Life Course.

Objective: This study identified associations between chronic diseases (diabetes, asthma, depression, and arthritis) and workforce participation patterns with a gendered perspective.

Method: We used data from 1,261 middle-aged participants of the Australian Life Histories and Health (LHH) Survey, aged 60 to 64 years in 2011. Latent class analysis identified dominant workforce patterns and associations between chronic diseases and these patterns were explored by multinomial regression models.

Why do diets fail? An exploration of dieters' experiences using thematic analysis.

Previous research has drawn on theoretical models and clinical observations to develop propositions regarding the mechanisms of diet failure, with only one study examining it directly from the perspective of dieters themselves. Furthermore, research to date has failed to provide an empirically validated, multi-factorial model of diet failure, despite the issue being recognised as a complex and multifaceted one. This study extended on previous research by examining themes of diet failure from the perspective of dieters ( n = 22) and health professionals in the field ( n = 5).

Biomarkers of drug-induced acute kidney injury in the adult.

Introduction: This article addresses general biomarkers of drug-induced acute kidney injury (AKI) and their application in development and progression of AKI in the adult. It also highlights some clinical benefits, but also uncertainties, of biomarker use.

Areas Covered: Drug-induced AKI is traditionally diagnosed by monitoring serum creatinine (SCr), blood urea nitrogen and albuminuria.

Researchers' perspectives on scientific and ethical issues with transcranial direct current stimulation: An international survey.

In the last decade, an increasing number of studies have suggested that transcranial direct current stimulation (tDCS) may enhance brain function in healthy individuals, and ameliorate cognitive and other symptoms in patients suffering from various medical conditions. This, along with its presumed safety, simplicity, and affordability, has generated great enthusiasm amongst researchers, clinicians, patient populations, and the public (including a growing "do-it-yourself" community). However, discussion about the effectiveness and ethics of tDCS thus far has been confined to small groups of tDCS researchers and bioethicists.

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.

Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis.

Biological interpretation of genome-wide association studies using predicted gene functions.

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

The contribution of genetic variants to disease depends on the ruler.

Our understanding of the genetic basis of disease has evolved from descriptions of overall heritability or familiality to the identification of large numbers of risk loci. One can quantify the impact of such loci on disease using a plethora of measures, which can guide future research decisions. However, different measures can attribute varying degrees of importance to a variant.

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking expression of estrogen and progesterone receptors (ER/PR) and HER2, thus limiting therapy options. We hypothesized that meta-analysis of TNBC gene expression profiles would illuminate mechanisms underlying the aggressive nature of this disease and identify therapeutic targets. Meta-analysis in the Oncomine database identified 206 genes that were recurrently deregulated in TNBC compared with non-TNBC and in tumors that metastasized or led to death within 5 years.

Predictors of change in weight and waist circumference: 15-year longitudinal study in Australian adults.

Background/objectives: This study examines which socio-demographic and lifestyle characteristics are associated with weight and waist circumference (WC) change in a cohort of Australian adults over a 15-year period (1992-2007). Further, it tests the effect of period of birth (birth cohort) on mean weight and WC at two time points, 15 years apart.

Subjects/methods: Up to three repeated measures of weight (n=1437) and WC (n=1317) were used.

Timing of colonoscopy after resection for colorectal cancer: are we looking too soon?

Background: Based on current National Comprehensive Cancer Network guidelines, colonoscopic surveillance after colorectal cancer resection should begin at 1 year.

Objective: The aim of this study was to determine whether the incidence of cancer or advanced polyp detection rate was high enough to justify colonoscopy at 1 year.

Design: The Ochsner Clinic Tumor Registry Database was queried for patients who underwent a segmental colectomy or proctectomy between 2002 and 2010.

The cancer biology of whole-chromosome instability.

One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic framework to explain this paradox.

Effectiveness of educational interventions to raise men's awareness of bladder and bowel health.

Executive Summary: Urinary incontinence (UI) has been defined as a condition in which the involuntary loss of urine is a social or hygienic problem and is objectively demonstrable. Urinary incontinence is a common health problem that carries with it significant medical, psychosocial and economic burdens. Fecal incontinence has been defined as the involuntary or inappropriate passing of liquid or solid stool and can also include the incontinence of flatus.