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Infectious complications of pancreatitis: diagnosis and management.
Curr Gastroenterol Rep
August 2004
Department of Internal Medicine, Section of Gastroenterology, Wake Forest University School of Medicine, 3rd Floor North Tower, 2 Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Infected pancreatic necrosis is the leading cause of death in patients with severe acute pancreatitis. Early prophylactic antibiotic treatment is effective in preventing conversion of sterile necrosis to pancreatic infection, but its effect on mortality remains unproven. Fungal infections may predict a worse outcome, but no evidence supports the use of antifungal prophylaxis.
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