2 results match your criteria: "2 Massachusetts General Hospital and Harvard Medical School[Affiliation]"
Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs.
J Aerosol Med Pulm Drug Deliv
June 2016
2 Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Background: Theoretical models suggest that He-O2 as carrier gas may lead to more homogeneous ventilation and aerosol deposition than air. However, these effects have not been clinically consistent and it is unclear why subjects may or may not respond to the therapy. Here we present 3D-imaging data of aerosol deposition and ventilation distributions from subjects with asthma inhaling He-O2 as carrier gas.
View Article and Find Full Text PDFWhat Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study.
J Aerosol Med Pulm Drug Deliv
February 2016
2 Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Background: A previous PET-CT imaging study of 14 bronchoconstricted asthmatic subjects showed that peripheral aerosol deposition was highly variable among subjects and lobes. The aim of this work was to identify and quantify factors responsible for this variability.
Methods: A theoretical framework was formulated to integrate four factors affecting aerosol deposition: differences in ventilation, in how air vs.