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Harman and norharman, metabolites of the entomopathogenic fungus (Entomophthorales), affect the serotonin levels and phagocytic activity of hemocytes, insect immunocompetent cells, in (Lepidoptera).
Cell Biosci
March 2019
1Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
Article Synopsis
- The study investigates the effects of β-carboline alkaloids harman and norharman, secreted by certain fungi, on serotonin levels and phagocytic activity in insect hemocytes.
- Significant increases in both serotonin levels and hemocyte phagocytic activity were observed after exposure to food contaminated with these alkaloids, but effects diminished after 24 hours.
- Findings highlight the potential role of harman and norharman in enhancing insect immune responses, which could influence future research in insect physiology, immunology, and pest control strategies.