What Are We Learning from Plant Pangenomes?

A single reference genome does not fully capture species diversity. By contrast, a pangenome incorporates multiple genomes to capture the entire set of nonredundant genes in a given species, along with its genome diversity. New sequencing technologies enable researchers to produce multiple high-quality genome sequences and catalog diverse genetic variations with better precision.

Gait Training Interventions for Individuals with Chronic Ankle Instability: A Systematic Review & Meta-Analysis.

Objective: This review aimed to determine if gait training interventions influence lower extremity biomechanics during walking in individuals with chronic ankle instability (CAI).

Methods: A literature search was conducted in PubMed, CINAHL, SPORTDiscus, and MEDLINE to identify English-language studies from inception through September 2022. Eligible studies included randomized control trials, repeated measures design, and descriptive laboratory studies measuring the effects during or following a gait training intervention on biomechanical outcomes (kinematics, kinetics, electromyography) during walking in individuals with CAI.

Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management.

Super-refractory status epilepticus (SRSE) is a life-threatening neurological emergency with high morbidity and mortality. It is defined as "status epilepticus (SE) that continues or recurs 24 hours or more after the onset of anesthesia, including those cases in which SE recurs on the reduction or withdrawal of anesthesia." This condition is resistant to normal protocols used in the treatment of status epilepticus and exposes patients to increased risks of neuronal death, neuronal injury, and disruption of neuronal networks if not treated in a timely manner.

An Atypical Case of Autochthonous Cutaneous Leishmaniasis Associated with Naturally Infected Phlebotomine Sand Flies in Texas, United States.

In the United States, phlebotomine sand flies carrying () are endemic along the southern border. However, relatively little is known about the enzootic and zoonotic transmission of () within the United States, and autochthonous cases of the consequent disease are rarely reported. We investigated an atypical case of cutaneous leishmaniasis (CL) caused by () in a patient from central Texas which did not respond to a typical antileishmanial chemotherapy.

Delivering Home-Supported Applied Behavior Analysis Therapies to Culturally and Linguistically Diverse Families.

The selection and adoption of culturally appropriate targets and practices, especially for home-based or parent-supported services, is an emerging interest in the field of applied behavior analysis (ABA). Variations in cultural norms, caregivers' ability to participate in home-based service delivery, and family and practitioner linguistic competencies are some of the areas that the culturally competent ABA therapist must consider when designing a home-based program of therapy. Given the paucity of empirical research related to cultural competency in ABA service provision, the goal of the current article is to provide practitioners, their supervisors, and researchers with information to overcome many perceived barriers to successfully working with clients whose home languages or cultures differ from that of the dominant U.

Bug Busters: Who you gonna call? Professional development for healthcare simulation technology specialists.

SimGHOSTS introduced Bug Busters to train healthcare simulation technology specialists (HSTSs) as a way to showcase experienced HSTSs' approaches to technology troubleshooting. This competition functions as a collaborative exchange of technology and operational solutions. It has been stated that Bug Busters is an equivalent to SimWars but for technology specialists.

Longitudinal Changes in Disability Rating Scale Scores: A Secondary Analysis Among Patients With Severe TBI Enrolled in the Epo Clinical Trial.

Objectives: Long-term neurological response to treatment after a severe traumatic brain injury (sTBI) is a dynamic process. Failure to capture individual heterogeneity in recovery may impact findings from single endpoint sTBI randomized controlled trials (RCT). The present study re-examined the efficacy of erythropoietin (Epo) and transfusion thresholds through longitudinal modeling of sTBI recovery as measured by the Disability Rating Scale (DRS).

Methods to evaluate rare variants gene-age interaction for triglycerides.

Triglycerides are an important measure of heart health. Although more than 90 genes have been found to be associated to lipids, they only explain 12 to 15% of the variance in lipid levels. Evidence suggests that age may interact with the genetic effect on lipid levels.

Out-of-pocket medical expenses in severe CHD.

Unlabelled: IntroductionFamilies of children born with CHD face added stress owing to uncertainty about the magnitude of the financial burden for medical costs they will face. This study seeks to assess the family responsibility for healthcare bills during the first 12 months of life for commercially insured children undergoing surgery for severe CHD.

Methods: The MarketScan ® database from Truven was used to identify commercially insured infants in 39 states from 2010 to 2012 with an ICD-9 diagnosis code for transposition of the great arteries, tetralogy of Fallot, or truncus arteriosus, as well as the corresponding procedure code for complete repair.

Cross-sectional sero-prevalence study of Peste des Petits Ruminants (PPR) in goats of Syangja and Kaski districts of Nepal.

A cross-sectional study was conducted to determine sero-prevalence of Peste des Petits Ruminants (PPR) among goat population of outbreak suspected areas; Kaski and Syangja districts of Nepal. A total of 460 goat serum samples were tested by using c-ELISA for the presence of antibodies against PPR. Out of the 460 samples tested, 380 samples were found positive, giving overall sero-positivity of 82.

Effects of Activation of Preferred Stimulus on Tummy Time Behavior of an Infant with Down Syndrome and Associated Hypotonia.

Infants with Down syndrome often have low muscle tone (hypotonia) and need activities designed to increase muscle tone (e.g., tummy time).

The biological roots of political extremism.

Recent research has revealed the complex origins of political identification and the possible effects of this identification on social and political behavior. This article reports the results of a structural equation analysis of national survey data that attempts to replicate the finding that an individual's negativity bias predicts conservative ideology. The analysis employs the Motivational Activation Measure (MAM) as an index of an individual's positivity offset and negativity bias.

Infant feeding practices and dietary consumption of US infants and toddlers: National Health and Nutrition Examination Survey (NHANES) 2003-2012.

Objective: To compare infant and toddler anthropometric measurements, feeding practices and mean nutrient intakes by race/ethnicity and income.

Design: Cross-sectional analysis using general linear modelling. Ten years of survey data (2003-2012) were combined to compare anthropometric measurements, feeding practices and mean nutrient intakes from a nationally representative US sample.

Impaired cerebral autoregulation and elevation in plasma glial fibrillary acidic protein level during cardiopulmonary bypass surgery for CHD.

Background: Cerebrovascular reactivity monitoring has been used to identify the lower limit of pressure autoregulation in adult patients with brain injury. We hypothesise that impaired cerebrovascular reactivity and time spent below the lower limit of autoregulation during cardiopulmonary bypass will result in hypoperfusion injuries to the brain detectable by elevation in serum glial fibrillary acidic protein level.

Methods: We designed a multicentre observational pilot study combining concurrent cerebrovascular reactivity and biomarker monitoring during cardiopulmonary bypass.

Erratum to: Family Enrichment Adventure Therapy: A Mixed Methods Study Examining the Impact of Trauma-Informed Adventure Therapy on Children and Families Affected by Abuse.

[This corrects the article DOI: 10.1007/s40653-017-0133-4.].

Family Enrichment Adventure Therapy: A Mixed Methods Study Examining the Impact of Trauma-Informed Adventure Therapy on Children and Families Affected by Abuse.

Child abuse is epidemic in the United States and has dire long-term consequences. Innovative interventions are needed to address the negative cognitive, affective and behavioral effects of child abuse. This mixed-method study examined if adventure therapy is 1) an effective mental health intervention for child and adolescent survivors of abuse and neglect, and 2) an effective intervention for families affected by abuse and neglect.

Human Trafficking, Sexual Assault, or Something Else? A Complicated Case With an Unexpected Outcome.

This case report presents a patient who presented multiple times with vaginal injuries and bleeding, reporting sexual assault with a foreign object. Findings from her history and physical examination were consistent with sexual assault and human trafficking. The outcome of this case was not what we initially expected when the patient first presented for care.

The association of binge eating and neighbourhood fast-food restaurant availability on diet and weight status.

Objective: Fast-food restaurants (FFR) are prevalent. Binge eating is common among overweight and obese women. For women prone to binge eating, neighbourhood FFR availability (i.

Translating research into practice: criteria for applying literature search results to your work.

Evidence-based practices in the fields of health education and health promotion require evaluating the validity and reliability of relevant and timely research. Skills associated with effectively assessing and applying research findings are essential when researchers and practitioners are developing a new program, writing a grant, or completing a research project. This Tool outlines steps and resources with which health educators and health promotion specialists can critically appraise the literature before deciding to apply a concept or practice.

Does the behavioral immune system prepare females to be religiously conservative and collectivistic?

Previous research has indicated that females are more likely than males to endorse collectivistic values and religious conservatism. The present research investigated an evolutionary explanation for these sex differences. More specifically, the sex differences in social conservatism may be due to variation in the behavioral immune system (BIS).

High-throughput screens for eEF-2 kinase.

eEF-2 kinase is a potential therapeutic target for breast cancer, gliomas, and depression. No potent inhibitors of eEF-2K have been reported, and thus development of high-throughput assay systems may expedite the process. Two high-throughput assays are described for eEF-2K using recombinant, tag-free enzyme purified from bacteria.

Sex differences in succumbing to sexual temptations: a function of impulse or control?

Men succumb to sexual temptations (e.g., infidelity, mate poaching) more than women.

Maintaining hope at the 11th hour: authenticity buffers the effect of limited time perspective on hope.

Four studies tested the hypothesis that limited time perceptions are associated with lower levels of hope, and that this effect is buffered by high levels of authenticity. Study 1 (n = 256) utilized a cross-sectional design in which participants completed dispositional measures of time perspective, hope, and authenticity. Three subsequent studies tested our hypothesis experimentally.

Do college drinkers learn from their mistakes? Effects of recent alcohol-related consequences on planned protective drinking strategies among college freshmen.

This study examined whether recent alcohol-related consequences affect intentions to use protective drinking strategies. Responses were collected from incoming college freshmen (N = 84,367) at 279 U.S.