THE SIGNIFICANCE OF CIRCULATING SURFACTANT PROTEIN D AND DYSLIPIDEMIA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CORONARY HEART DISEASE AND THEIR COMBINATION.

As it is widely known, cardiovascular diseases represent one of the leading causes of mortality. In the coexistence of chronic obstructive pulmonary disease (COPD), the mortality rate is increasing as well. The research conducted reviews the effect of surfactant protein D on the coronary heart disease and chronic obstructive pulmonary disease.

"EX VIVO" MACHINE PRESERVATION OF THE ABDOMINAL ORGANS OF A PIG.

The aim of the study is to test the developed perfusion machine for long-term preservation of the liver, to evaluate the perfusion scheme that provides two different (arterial and venous) flows, and to evaluate hemodynamic of parallel perfusion of the liver together with the kidney. We have developed a perfusion machine to enable simultaneous perfusion of the liver and kidney, based on clinically proven constant flow blood pump. In the developed device, constant blood flow is converted into pulsed blood flow using a device of its own design - a pulsator.

DIFFUSE LUNG DISEASE: A CASE REPORT.

The purpose of the work was to demonstrate that an early stage diagnosis of the interstitial lung disease would allow establishing the proper treatment course and as a result, increase life expectancy and quality in patients with this disorder. More than 200 acute and chronic conditions with inflammatory and fibroproliperative changes comprise the group of diffuse lung diseases. Definitive diagnosis cannot be made based on chest X-ray only.

EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON "AGED" HETEROCHROMATIN.

Following the completion of the Human Genome Project, the strategic direction of modern genetics has moved toward functional genomics, to explore the functions of non-coding regions of DNA. These non-coding regions are localized in heterochromatin. The functions of heterochromatin largely remain unclear.

REVIVAL OF MICROBIAL THERAPEUTICS, WITH EMPHASIS ON PROBIOTIC LACTOBACILLUS (REVIEW).

The idea to use living microorganisms for disease prevention and treatment was introduced a century ago, but yet the full potential and benefits of microbial therapeutics has not been entirely understood. In the light of developments of human microbiome studies, probiotics are gaining new momentum, where health benefit conferring by Lactobacillus are emerging as one of the novel approaches in the treatment and prophylactics of dysbiosis. The present review focuses on the origin and development of the probiotic's concept, mechanisms of action and anticipated use of probiotic Lactobacillus as well as of microbial therapeutics.

[; PROBLEMS OF MONITORING THE QUALITY OF HOSPITALS IN GEORGIA IN THE CONTEXT OF THE COVID 19 PANDEMIC (REVIEW)].

The purpose of the study - scientific justification, development and implementation of an automated information system for assessing the results of the examination of quality and technology of medical care in hospitals at the regional level.; Based on the developed unified expert map for assessing the quality and technology of medical care, a mathematical model is built and the quantification method is used to form a unified regional system for automated monitoring of the quality of medical care in hospitals. The use of this system of monitoring the quality of medical care allows using the statistical methods to manage the quality of care ; to form homogeneous groups of patients according to specific parameters (nozology, gender, age, severity of condition, etc.