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Background: Depression in HIV/AIDS children not only worsens the progression and outcome of illness, but also impacts their quality of life, having a negative influence on society. The present study was conducted from a psychosocial perspective, considering children's social desirability, cognitive emotion regulation, and perceived social support to identify the factors influencing depression in HIV-infected children in China.

Methods: Participants were 155 children aged 8-18 years who were eligible to participate in this study assessing depression and associated risk factors using the Children's Depression Inventory, Cognitive Emotion Regulation Questionnaire, Multidimensional Scale of Perceived Social Support, and Children's Social Desirability scale.

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